Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis

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Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis is …
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scholarly articleQ13442814

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P356DOI10.3390/PH11040105
P932PMC publication ID6315622
P698PubMed publication ID30326593

P2093author name stringAndy Weyer
Jose Reyna
Tabitha Galindo
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GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal modelsQ46245642
Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient miceQ46438614
TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization.Q46709161
TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute goutQ46900003
Involvement of transient receptor potential melastatin-8 (TRPM8) in menthol-induced calcium entry, reactive oxygen species production and cell death in rheumatoid arthritis rat synovial fibroblastsQ46944503
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Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice--potential role for transient receptor potential ankyrin 1 in goutQ28543261
The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasionQ28573570
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TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronanQ33595202
Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior.Q34075112
Contribution of transient receptor potential ankyrin 1 to chronic pain in aged mice with complete Freund's adjuvant-induced arthritisQ34109166
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Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.Q34522629
Use of non-steroidal anti-inflammatory drugs that elevate cardiovascular risk: an examination of sales and essential medicines lists in low-, middle-, and high-income countriesQ34592490
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis painQ34818013
Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging studyQ35092969
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Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation?Q35128894
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritisQ35138392
Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritisQ35146980
Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritisQ35554444
Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture studyQ35769063
Afferent drive elicits ongoing pain in a model of advanced osteoarthritisQ35855535
Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent mannerQ35891181
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine kneesQ36037155
Polymodal Transient Receptor Potential Vanilloid (TRPV) Ion Channels in Chondrogenic CellsQ36088570
Comparison of reliability and responsiveness of patient-reported clinical outcome measures in knee osteoarthritis rehabilitationQ36213481
Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient miceQ36477409
The molecular and cellular basis of cold sensationQ36657613
Safety, Pharmacokinetics, and Pharmacodynamics Study in Healthy Subjects of Oral NEO6860, a Modality Selective Transient Receptor Potential Vanilloid Subtype 1 Antagonist.Q50898491
Synovial TRPV1 is upregulated by 17-β-estradiol and involved in allodynia of inflamed temporomandibular joints in female rats.Q51012013
Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout.Q52661324
GoutQ54087165
Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia.Q54472108
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.Q55034856
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I.Q55047291
CD147 up-regulates calcium-induced chemotaxis, adhesion ability and invasiveness of human neutrophils via a TRPM-7-mediated mechanism.Q55072775
Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolismQ56169415
Rheumatoid arthritisQ56656479
The association between arthritis and the weatherQ57134073
A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritisQ57898575
Differences in synovial tissue infiltrates between anti–cyclic citrullinated peptide–positive rheumatoid arthritis and anti–cyclic citrullinated peptide–negative rheumatoid arthritisQ58234928
Concomitant use of low-dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritisQ61848957
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice – potential role of TRPA1 in osteoarthritisQ62641626
Capsaicin effects on substance P and CGRP in rat adjuvant arthritisQ63208639
Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritisQ63406968
Concentration of substance P, neurokinin A, calcitonin gene-related peptide, neuropeptide Y and vasoactive intestinal polypeptide in synovial fluid from knee joints in patients suffering from rheumatoid arthritisQ68053396
Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee jointsQ69654179
Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritisQ69696757
Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritisQ72693365
Intraneuronal substance P contributes to the severity of experimental arthritisQ72749066
The analgesic efficacy of topical capsaicin is enhanced by glyceryl trinitrate in painful osteoarthritis: a randomized, double blind, placebo controlled studyQ73313656
GoutQ73472123
Rheumatoid Arthritis of the HipQ73743573
Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritisQ80461012
Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytesQ82213748
TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic painQ82293771
Civamide cream 0.075% in patients with osteoarthritis of the knee: a 12-week randomized controlled clinical trial with a longterm extensionQ82534212
Different stages of rheumatoid arthritis: features of the synovium in the preclinical phaseQ82991564
Efficacy of ABT-116, an antagonist of transient receptor potential vanilloid type 1, in providing analgesia for dogs with chemically induced synovitisQ83147793
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in ratsQ84060628
Rheumatoid arthritis: where are we now?Q84425357
Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-κB translocation and ROS production in synoviocytesQ84504734
Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008Q84617958
Neuropeptides activate TRPV1 in rheumatoid arthritis fibroblast-like synoviocytes and foster IL-6 and IL-8 productionQ86208498
Participation of the TRPV1 receptor in the development of acute gout attacksQ86637247
Inhibition of transient receptor potential melastatin 7 (TRPM7) channel induces RA FLSs apoptosis through endoplasmic reticulum (ER) stressQ87682822
Aspects of the biology of hyaluronan, a largely neglected but extremely versatile moleculeQ36679390
New therapies for treatment of rheumatoid arthritisQ36849874
Vanilloid receptor TRPV1-positive sensory afferents in the mouse ankle and knee jointsQ36862026
Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparatorQ36903272
TRPA1 and cold transduction: an unresolved issue?Q37124273
Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes.Q37169416
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?Q37198480
Intra-articular Hyaluronic Acid in Treating Knee Osteoarthritis: a PRISMA-Compliant Systematic Review of Overlapping Meta-analysisQ37247421
The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot studyQ37321292
Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammationQ37604540
The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies.Q37606213
A systematic comparison of combination DMARD therapy and tumour necrosis inhibitor therapy with methotrexate in patients with early rheumatoid arthritisQ37633796
Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity.Q37723272
Gout therapeutics: new drugs for an old diseaseQ37780849
The Role of Transient Receptor Potential Cation Channels in Ca2+ SignalingQ37791280
A "cute" desensitization of TRPV1.Q37798852
Genetic epidemiology of hip and knee osteoarthritisQ37809747
The transient receptor potential family of ion channelsQ37852820
Gout: current insights and future perspectivesQ37940064
Reactive oxygen species: the 2-edged sword of osteoarthritisQ38034003
The fibroblast as a therapeutic target in rheumatoid arthritisQ38096642
Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities.Q38216302
Zucapsaicin for the treatment of neuropathic pain.Q38244583
Role of IL-17 and IL-22 in autoimmunity and cancerQ38268323
An update on the pathophysiology of osteoarthritisQ38829272
Hypotonic stress promotes ATP release, reactive oxygen species production and cell proliferation via TRPV4 activation in rheumatoid arthritis rat synovial fibroblastsQ38919808
Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodiesQ39070631
Efficacy, safety and pharmacokinetics of biosimilars of anti-tumor necrosis factor-α agents in rheumatic diseases; A systematic review and meta-analysisQ39139509
Acidosis of synovial fluid correlates with synovial fluid leukocytosisQ39194003
Biologics in the treatment of chronic pain: a new era of therapy?Q39194391
Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritisQ39364082
Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes.Q40295239
Using gait analysis to assess weight bearing in rats with Freund׳s complete adjuvant-induced monoarthritis to improve predictivity: Interfering with the cyclooxygenase and nerve growth factor pathwaysQ41190112
Auranofin: repurposing an old drug for a golden new age.Q41474201
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine releaseQ42325393
Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofinQ42713895
Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritisQ43140210
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptorsQ43151051
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P577publication date2018-10-15
P1433published inPharmaceuticalsQ15750667
P1476titleEvidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis
P478volume11

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cites work (P2860)
Q64229773A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis
Q90522829Identification and Quantification of Transient Receptor Potential Vanilloid 1 (TRPV1) in Equine Articular Tissue
Q113621906TRP channels and monoterpenes: Past and current leads on analgesic properties

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