Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage

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Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage is …
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scholarly articleQ13442814

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P356DOI10.1007/S00011-018-1193-0
P698PubMed publication ID30317465

P50authorTadahiro HashitaQ87624326
Satoshi KondoQ89476055
Tamihide MatsunagaQ92261536
Takahiro IwaoQ92525222
P2093author name stringShota Mizuno
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Generation of enterocyte-like cells with pharmacokinetic functions from human induced pluripotent stem cells using small-molecule compoundsQ35554963
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Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trialQ36040552
Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells.Q36078060
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TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation.Q40467064
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Rebamipide protects small intestinal mucosal injuries caused by indomethacin by modulating intestinal microbiota and the gene expression in intestinal mucosa in a rat modelQ41361724
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Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotilityQ44855808
Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitroQ44870924
Cinacalcet, a calcimimetic, prevents nonsteroidal antiinflammatory drug-induced small intestinal damage in ratsQ44943681
Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo modelQ44981253
Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopyQ46108964
A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopyQ46485023
Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation.Q47688891
Interaction of indomethacin with cytokine production in whole blood. Potential mechanism for a brain-protective effectQ49145776
Rebamipide increases mucin-like substance contents and periodic acid Schiff reagent-positive cells density in normal rabbitsQ50254467
Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.Q54601716
Positive effect of rebamipide on gastric permeability in mice after eradication of Helicobacter felisQ73927834
Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled studyQ77348864
Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in ratsQ77348911
Assessing the efficacy of famotidine and rebamipide in the treatment of gastric mucosal lesions in patients receiving long-term NSAID therapy (FORCE--famotidine or rebamipide in comparison by endoscopy)Q79745265
Cyclic AMP Signaling Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Intestinal Epithelial CellsQ90696095
P433issue11-12
P407language of work or nameEnglishQ1860
P304page(s)975-984
P577publication date2018-10-13
P1433published inInflammation ResearchQ1819367
P1476titleUsing human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage
P478volume67

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Q80019346Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug-induced adverse eventscites workP2860

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