EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

scientific article published in Nature Communications

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription is …
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scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9.4239A
P356DOI10.1038/S41467-018-06208-Y
P932PMC publication ID6185954
P698PubMed publication ID30315161

P50authorYi ZhangQ57480296
Edward AyoubQ58517942
Archibald S PerkinsQ58670822
Kathleen E McGrathQ92246497
Laura M. CalviQ42723493
P2093author name stringMichael P Wilson
James Palis
Benjamin J Frisch
Allison J Li
P2860cites workPbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cellsQ24317653
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemiaQ24597256
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1Q24671782
Infection-induced changes in hematopoiesisQ27027365
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsQ28209409
Identification of binding sites of EVI1 in mammalian cellsQ28260755
The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapyQ28266315
The LMO2 oncogene regulates DNA replication in hematopoietic cellsQ28272026
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell linesQ28281211
Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient miceQ28510979
Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis mediaQ28586559
PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell functionQ33395759
Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute myelogenous leukemia in miceQ42832388
Analysis of hematopoietic progenitors in the mouse embryoQ45113266
Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.Q45345900
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.Q46456469
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineagesQ46678691
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cellsQ46885318
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.Q47597394
3q26.2/EVI1 rearrangement is associated with poor prognosis in classical Philadelphia chromosome-negative myeloproliferative neoplasms.Q50776559
Chromosomal abnormality inv(3)(q21q26) associated with multilineage hematopoietic progenitor cells in hematopoietic malignanciesQ51102350
Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.Q52112384
High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.Q54546717
Regulation of the PU.1 gene by distal elementsQ57615588
Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse developmentQ67975653
Common sites of viral integration in lymphomas arising in AKXD recombinant inbred mouse strainsQ68846816
The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAGQ72420809
Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26)Q72699060
Erythroid defects and increased retrovirally-induced tumor formation in Evi1 transgenic miceQ73166088
New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patientsQ80860421
Myelodysplastic syndrome with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) has a high risk for progression to acute myeloid leukemiaQ84561568
NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemiasQ85201352
Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemiaQ93644788
Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generationQ33569847
Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating systemQ34263796
Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group studyQ34369958
Recombineering: a powerful new tool for mouse functional genomicsQ34389493
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemiaQ34413730
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissuesQ34417194
Transcriptome-wide noise controls lineage choice in mammalian progenitor cellsQ34780848
Global Identification of EVI1 Target Genes in Acute Myeloid LeukemiaQ34796524
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrowQ35951254
The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.Q36011931
EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylationQ36016473
Cutting Edge: Hematopoietic Stem Cell Expansion and Common Lymphoid Progenitor Depletion Require Hematopoietic-Derived, Cell-Autonomous TLR4 in a Model of Chronic Endotoxin.Q36031575
Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitorsQ36219652
Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte productionQ36368599
Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitorsQ36402594
Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndromeQ36547805
Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding proteinQ36692472
Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice.Q36721547
Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamideQ36749396
Toll-like receptor 4/stem cell antigen 1 signaling promotes hematopoietic precursor cell commitment to granulocyte development during the granulopoietic response to Escherichia coli bacteremia.Q36911380
EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory ElementsQ37034398
Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway.Q37195600
Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemiaQ37235697
The anemia of inflammationQ38065016
The role of EVI1 in myeloid malignanciesQ38185179
Emergency granulopoiesisQ38206076
A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expressionQ39313400
Inferring rules of lineage commitment in haematopoiesisQ39394890
EVI1 Impairs myelopoiesis by deregulation of PU.1 functionQ39885071
EVI1 induces myelodysplastic syndrome in miceQ39951095
Regulation of CCAAT/enhancer-binding protein (C/EBP) activator proteins by heterodimerization with C/EBPgamma (Ig/EBP).Q40735316
PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA bindingQ40850691
Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid developmentQ41414243
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.Q42194328
Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic miceQ42773641
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectgeneral chemistryQ909510
hemopoiesisQ919283
overexpressionQ61643320
P304page(s)4239
P577publication date2018-10-12
P1433published inNature CommunicationsQ573880
P1476titleEVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
P478volume9