Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

scientific article published on 11 October 2018

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CMET.2018.09.019
P932PMC publication ID6365216
P698PubMed publication ID30318339

P50authorAlexandra C McQuattie-PimentelQ47160053
Hiam Abdala-ValenciaQ57326080
Manu JainQ61185375
Gökhan M MutluQ88316639
Stephen ChiuQ88488453
P2093author name stringMurali Prakriya
Richard I Morimoto
Navdeep S Chandel
William E Balch
Alexander V Misharin
G R Scott Budinger
Harris Perlman
Luisa Morales-Nebreda
Jacob I Sznajder
Sangeeta M Bhorade
Andrew J Ghio
Ankit Bharat
Karen M Ridge
Amit Jairaman
Monica Chi
Ching-I Chen
Francisco J Gonzalez-Gonzalez
Angelo Y Meliton
Kaitlyn A Sun
Parker S Woods
Robert B Hamanaka
James M Walter
Matthew Antalek
Paul A Reyfman
Saul Soberanes
Sergio E Chiarella
Takugo Cho
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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream To Identify Novel Targets for AtheroprotectionQ26770209
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator proteinQ27933227
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative diseaseQ28252463
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lungQ28390828
Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lungQ28394834
Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent BiosynthesisQ28551227
Fine-particulate air pollution and life expectancy in the United StatesQ29615985
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesQ29620142
β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosisQ30581666
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle developmentQ33596134
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisQ33597162
Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cellsQ33832147
Metformin improves healthspan and lifespan in miceQ34360789
Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysisQ34522524
Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPKQ35116609
Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epitheliumQ35791001
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic CellsQ35864608
Interventions to Slow Aging in Humans: Are We Ready?Q35935123
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathwayQ35995696
Suppressors of superoxide production from mitochondrial complex IIIQ36200360
Store-Operated Ca2+ Release-Activated Ca2+ Channels Regulate PAR2-Activated Ca2+ Signaling and Cytokine Production in Airway Epithelial CellsQ36210515
Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cellsQ36252857
Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cellsQ37240146
Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosisQ37725485
Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air PurificationQ38372204
Antiinflammatory Therapy with Canakinumab for Atherosclerotic DiseaseQ38606033
Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human CancersQ38740928
Metformin as a Tool to Target AgingQ38865781
Air Pollution and Mortality in the Medicare PopulationQ40142747
Gated regulation of CRAC channel ion selectivity by STIM1.Q40999366
Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion InjuryQ42383841
Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and MiceQ42553800
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondriaQ42848863
Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.Q42984890
Atmosphere. Air pollution-related illness: effects of particlesQ46477528
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.Q47939968
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.Q52668520
Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?Q52853614
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
thrombosisQ261327
mitochondrionQ39572
air pollutionQ131123
P304page(s)335-347.e5
P577publication date2018-10-11
P1433published inCell MetabolismQ1254684
P1476titleMetformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis
P478volume29

Reverse relations

cites work (P2860)
Q99557127Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis
Q90698749Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells
Q59798105Particulate Matter Air Pollution: Effects on the Cardiovascular System
Q91598124Targeting senescent cells: approaches, opportunities, challenges

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