IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle

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IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00592-011-0259-Z
P698PubMed publication ID21293887

P50authorSeung Jin HanQ42871469
P2093author name stringDae Jung Kim
Tae Ho Kim
Hae Jin Kim
Kwan Woo Lee
Yup Kang
Jong Gab Jung
Eun Suk Ha
Sung E Choi
P2860cites workInterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistanceQ29012156
TLR4 links innate immunity and fatty acid-induced insulin resistanceQ29617577
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitusQ29619398
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humansQ33755056
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.Q34449273
Inflammation and activated innate immunity in the pathogenesis of type 2 diabetesQ35677410
Innate immunity in the liverQ36036373
Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjectsQ36906306
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.Q37216733
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysQ38297619
Interleukin-6 depletion selectively improves hepatic insulin action in obesityQ38327645
Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathwayQ40053974
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseQ40227253
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytesQ40266335
Activation of opioid mu-receptors by loperamide to improve interleukin-6-induced inhibition of insulin signals in myoblast C2C12 cellsQ40408658
Interleukin-6 induces cellular insulin resistance in hepatocytesQ40687381
Insulin resistance and diabetes mellitusQ41183836
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscleQ42135596
Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose outputQ42467904
ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblastsQ42511347
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjectsQ42797512
Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet.Q43439880
Palmitate-induced apoptosis can occur through a ceramide-independent pathwayQ43559742
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylationQ43699235
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitroQ43982432
Chronic exposure to interleukin-6 causes hepatic insulin resistance in miceQ44631827
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivoQ44816750
How obesity causes diabetes: not a tall taleQ45232061
Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice.Q45877031
Classical PKC is not associated with defective insulin signaling in patients with impaired glucose toleranceQ46174690
Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazoneQ46620643
Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscleQ46865480
Role of hepatic STAT3 in brain-insulin action on hepatic glucose productionQ48596967
Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes.Q53538930
Increased number of islet-associated macrophages in type 2 diabetes.Q53545508
Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight LossQ56096259
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistanceQ56742768
Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal MuscleQ58449836
P433issue2
P921main subjecttoll-like receptorQ408004
insulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)189-200
P577publication date2011-02-04
P1433published inActa DiabetologicaQ15749690
P1476titleIL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle
P478volume50

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cites work (P2860)
Q27026242A Potential Role for Pro-Inflammatory Cytokines in the Development of Insulin Resistance in Horses
Q26830077Adipocytes: impact on tumor growth and potential sites for therapeutic intervention
Q36146424Adiposity and immune-muscle crosstalk in South Asians &Europeans: A cross-sectional study
Q33849609Alantolactone Improves Prolonged Exposure of Interleukin-6-Induced Skeletal Muscle Inflammation Associated Glucose Intolerance and Insulin Resistance
Q36560528Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes
Q34361828Evaluation of Toll-Like receptor 2 and 4 RNA expression and the cytokine profile in postmenopausal women with metabolic syndrome
Q26748964Influence of Acute and Chronic Exercise on Glucose Uptake
Q39148436Innate immune receptors in skeletal muscle metabolism.
Q34297417Interleukin-6 deficiency causes tissue-specific changes in signaling pathways in response to high-fat diet and physical activity
Q60472237Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults
Q64967941Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases.
Q35929484Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance
Q36580093Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects
Q35744922Mechanisms Linking Inflammation to Insulin Resistance
Q42359004Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages
Q92683056Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila
Q38222831Obesity and resistance to cancer chemotherapy: interacting roles of inflammation and metabolic dysregulation
Q58802831STAT3 in Skeletal Muscle Function and Disorders
Q36900212Signal transducer and activator of transcription 3 signaling as a potential target to treat muscle wasting diseases
Q89890713Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40
Q90613619Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders
Q37309992The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK.
Q38773189The JAK/STAT pathway in obesity and diabetes
Q45261661The effect of chromium on inflammatory markers, 1st and 2nd phase insulin secretion in type 2 diabetes
Q36028206The effect of exercise on IL-6-induced cachexia in the Apc ( Min/+) mouse
Q36931512The role of chronic inflammation in obesity-associated cancers
Q38140767The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications--a review

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