Molecular targets of lithium action

Molecular targets of lithium action is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1601-5215.2003.00049.X
P698PubMed publication ID26983769

P50authorEduard VietaQ20090640
P2093author name stringB Corbella
P2860cites workCloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphateQ22009472
Antidepressant and circadian phase-shifting effects of lightQ22299407
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesisQ24309150
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-cateninQ24313571
Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structureQ24562986
A molecular mechanism for the effect of lithium on developmentQ24629067
Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapyQ27637498
Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphataseQ27729690
Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolutionQ27730735
Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysisQ27730870
A salt-sensitive 3'(2'),5'-bisphosphate nucleotidase involved in sulfate activationQ27933490
Differential display of eukaryotic messenger RNA by means of the polymerase chain reactionQ28131789
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activationQ28140761
Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brainQ28141275
Control of transcription factors by signal transduction pathways: the beginning of the endQ28209088
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formationQ28244304
Neural and developmental actions of lithium: a unifying hypothesisQ28254375
Emergent properties of networks of biological signaling pathwaysQ28293858
Rapid Cycling in Manic-Depressives Induced by Tricyclic AntidepressantsQ28326442
Analysis of the convulsant-potentiating effects of lithium in ratsQ28326990
Potentiation of malaoxon-induced convulsions by lithium: early neuronal injury, phosphoinositide signaling, and calciumQ28335526
Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analogQ28342327
Effect of lithium on tachykinins, calcitonin gene-related peptide, and neuropeptide Y in rat brainQ48955715
Activation of the Wnt signaling pathway: a molecular mechanism for lithium actionQ48958687
Regular 48-hour cycling of sleep duration and mood in a 35-year-old woman: use of lithium in time isolationQ49014011
Effects of chronic lithium treatment on dopamine receptors in the rat corpus striatum. I. Locomotor activity and behavioral supersensitivityQ49016525
Effects of lithium carbonate on methylphenidate-induced mood, behavior, and cognitive processes.Q51262013
A double-blind, placebo-controlled study of the effects of lithium on cognition in healthy subjects: mild and selective effects on learning.Q52023319
Hyperfunctional G proteins in mononuclear leukocytes of patients with mania.Q52052203
Lithium therapy and signal transduction.Q52171133
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.Q53199978
Comparison of acute and chronic lithium treatment on 3H-norepinephrine uptake by rat brain slices.Q54259005
Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression.Q54368435
Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells.Q55479349
Pro-opiomelanocortin-related peptides in cerebrospinal fluid: A study of manic-depressive disorderQ57268961
[20] Analysis of altered gene expression by differential displayQ58883576
Antiaversive properties of opioids in the conditioned taste aversion test in the rat.Q42100485
Lithium attenuates the activation-euphoria but not the psychosis induced by d-amphetamine in schizophreniaQ42226216
Effect of chronic lithium on cholinergically mediated responses and [3H]QNB binding in rat brainQ42229123
Effect of low-dose lithium administration and subsequent withdrawal on biogenic amines in rat brainQ42232690
Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjectsQ42437441
The mechanisms of action of lithium. II. Effects on adenylate cyclase activity and beta-adrenergic receptor binding in normal subjectsQ42462481
Alteration in the regulation of neuronal muscarinic acetylcholine receptor number induced by chronic lithium in neuroblastoma cellsQ42501634
Effects of chronic lithium treatment on serotonin binding sites in rat brainQ43586009
Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizersQ43594287
Effect of Li+ upon the Mg2+-dependent activation of recombinant Gialpha1.Q43613595
Lithium-Sensitive Production of Inositol Phosphates During Amphibian Embryonic Mesoderm InductionQ43688434
Tetraspan protein CD151: a common target of mood stabilizing drugs?Q43781213
Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sitesQ43858813
Iontophoresis of lithium antagonizes noradrenergic action on prefrontal neurons of the rat.Q44080764
Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depressionQ44133502
Stimulation of hypothalamic opioid peptide release by lithium is mediated by opioid autoreceptors: evidence from a combined in vitro, ex vivo studyQ44338534
Involvement of beta-endorphin and mu-opioid receptors in mediating the aversive effect of lithium in the rat.Q44343686
Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioningQ44346240
Activation of protein kinase C alters the interaction of alpha 2-adrenoceptors and the inhibitory GTP-binding protein (Gi) in human plateletsQ44755108
The mechanisms of action of lithium. I. Effects on serotoninergic and noradrenergic systems in normal subjectsQ45134248
Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by winglessQ45247642
Interactions among lithium, calcium, diacylglycerides, and phorbol esters in the regulation of adrenocorticotropin hormone release from AtT-20 cellsQ46171516
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclaseQ46680546
Lithium stimulates gene expression through the AP-1 transcription factor pathwayQ47759848
Lithium regulation of aldolase A expression in the rat frontal cortex: identification by differential displayQ47842223
Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.Q47877188
A novel target of lithium therapyQ47884637
Circadian rhythms. New cogwheels in the clockworksQ47924272
Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortexQ48112918
Brain G-protein proteolysis by calpain: enhancement by lithiumQ48174770
Effects of chronic lithium treatments on central dopaminergic receptor systems: G proteins as possible targetsQ48208353
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depressionQ48208784
Influence of the pineal gland on pituitary function in humansQ48229127
Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brainQ48258835
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule bindingQ48277664
Valproate robustly enhances AP-1 mediated gene expressionQ48305334
Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.Q48394153
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinaseQ48406074
Chronic lithium treatment impairs phosphatidylinositol hydrolysis in membranes from rat brain regionsQ48474283
Subchronic treatment with lithium increases nerve growth factor content in distinct brain regions of adult ratsQ48532736
Chronic lithium administration alters a prominent PKC substrate in rat hippocampusQ48546705
Combined lithium and valproate treatment and subsequent withdrawal: serotonergic mechanism of their interaction in discrete brain regionsQ48561312
Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neuronsQ48658321
Subgenual prefrontal cortex abnormalities in mood disordersQ48725544
Increase in AP-1 transcription factor DNA binding activity by valproic acidQ48773462
Lithium decreases Gs, Gi-1 and Gi-2 alpha-subunit mRNA levels in rat cortexQ48793249
Chronic lithium treatment prevents atropine-induced supersensitivity of the muscarinic phosphoinositide response in rat hippocampusQ48889521
Enhanced protein kinase C activity and translocation in bipolar affective disorder brainsQ48907362
Li+/Mg2+ competition at therapeutic intracellular Li+ levels in human neuroblastoma SH-SY5Y cellsQ48947878
Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in ratsQ48949943
Intracerebroventricular antisense to inositol monophosphatase-1 reduces enzyme activity but does not affect Li-sensitive behaviorQ28566390
The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNSQ28570728
Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brainQ28575972
A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphataseQ28583454
WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neuronsQ28586422
Wnt signaling: a common theme in animal developmentQ29547527
Inositol phosphates and cell signallingQ29615042
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cellsQ29618245
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase CQ29620247
Lithium stimulation of HPP-CFC and stromal growth factor production in murine Dexter cultureQ30436037
New insights into the role and mechanism of glycogen synthase activation by insulinQ30470182
Designing small-molecule switches for protein-protein interactionsQ30880060
Anti-bipolar therapy: mechanism of action of lithiumQ33596950
Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challengeQ33750436
Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illnessQ33782621
Cognitive dysfunctions in bipolar disorder: evidence of neuropsychological disturbances.Q33796802
Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illnessQ33809252
Complexity in biological signaling systemsQ33844786
Lithium evokes expression of vegetal-specific molecules in the animal blastomeres of sea urchin embryosQ33857336
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cellsQ33924323
Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.Q33957378
Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axinQ33959834
A molecular and cellular theory of depressionQ34064955
Neuroplasticity and cellular resilience in mood disordersQ34111006
A common mechanism of action for three mood-stabilizing drugsQ34128871
Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivoQ34183479
Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studiesQ34185330
Abnormalities in protein kinase C signaling and the pathophysiology of bipolar disorderQ34185366
Lithium and synaptic plasticity.Q34185371
Molecular targets of lithium actionQ34192797
Lithium-related genetics of bipolar disorderQ34281207
In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.Q34355076
Alternate energy coupling of ArsB, the membrane subunit of the Ars anion-translocating ATPaseQ34413287
Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influxQ34458296
Lithium treatment at 52.Q34547096
Glycogen synthase kinase 3: an emerging therapeutic targetQ34552674
PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizersQ34622380
Neuroprotective effects of lithium in cultured cells and animal models of diseases.Q34692758
Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?Q34714351
Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?Q34726336
Initiation and adaptation: a paradigm for understanding psychotropic drug actionQ34732299
Mood stabilizer combinations: a review of safety and efficacyQ34744469
Inositol Lipids and Signal Transduction in the Nervous System: An UpdateQ35224675
G proteins: implications for psychiatryQ35255728
Toward a crystal-clear view of lithium's site of action.Q35529747
A cell-free assay system for beta-catenin signaling that recapitulates direct inductive events in the early xenopus laevis embryoQ36326068
Chronic lithium regulates the expression of adenylate cyclase and Gi-protein alpha subunit in rat cerebral cortexQ37632156
Expression of striatal D1 dopamine receptors coupled to inositol phosphate production and Ca2+ mobilization in Xenopus oocytesQ37720646
Lithium and serotonin function: implications for the serotonin hypothesis of depressionQ38138445
The mechanism of protein kinase C activationQ38208888
GTP-binding proteins as possible targets for protein kinase C actionQ38240180
Signal transmission by the insulin-like growth factorsQ38297337
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activityQ38336655
Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithiumQ38364991
Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophyQ39499902
Lithium inhibition of adrenaline-stimulated adenylate cyclase in humansQ39975414
Signal transduction pathways. Molecular targets for lithium's actionsQ40437069
Lithium in the treatment of mood disordersQ40681257
Lithium and brain signal transduction systemsQ40719294
Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.Q40808111
Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.Q40888981
Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositolQ40925779
Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryosQ40939820
Evidence that a proconvulsant action of lithium is mediated by inhibition of myo-inositol phosphatase in mouse brainQ41131004
Lithium increases 5-HT-mediated prolactin release.Q41262711
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.Q41423732
Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonateQ41571807
Effects of lithium therapy on mao in manic-depressive illnessQ41601144
Lithium delays biochemical circadian rhythms in ratsQ41601466
Effect of secretagogues on components of the secretory system in AtT-20 cellsQ41746912
Effects of lithium and insulin on glycogen synthesis in L6 myocytes: additive effects on inactivation of glycogen synthase kinase-3.Q41750681
Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker ratsQ41905840
Effect of short- and long-term administration of lithium on the release of endogenous 5-HT in the hippocampus of the rat in vivo and in vitroQ41953702
Reduced inositol polyphosphate accumulation and inositol supply induced by lithium in stimulated cerebral cortex slicesQ42008702
In Vivo Evidence that Lithium Inactivates Gi Modulation of Adenylate Cyclase in BrainQ42013568
P433issue06
P304page(s)316-340
P577publication date2003-12-01
P1433published inActa NeuropsychiatricaQ4676734
P1476titleMolecular targets of lithium action
P478volume15

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cites work (P2860)
Q60922281A Dynamical Bifurcation Model of Bipolar Disorder Based on Learned Expectation and Asymmetry in Mood Sensitivity
Q33284843A systematic review of existing data on long-term lithium therapy: neuroprotective or neurotoxic?
Q38846631Antiviral effect of lithium chloride on feline calicivirus in vitro
Q92404899Dopamine D3 receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice
Q46255549Outer dense fibers stabilize the axoneme to maintain sperm motility.
Q37219221Prefrontal gray matter increases in healthy individuals after lithium treatment: a voxel-based morphometry study
Q48397787Restraint stress influences AP-1 and CREB DNA-binding activity induced by chronic lithium treatment in the rat frontal cortex and hippocampus
Q37665567Treatment of psychotic symptoms in bipolar disorder with aripiprazole monotherapy: a meta-analysis
Q61775436Vigencia del tratamiento con litio

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