Ligand-Assisted Vascular Targeting of Polymer Therapeutics

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Ligand-Assisted Vascular Targeting of Polymer Therapeutics is …
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scholarly articleQ13442814

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P356DOI10.1002/9783527634057.CH20

P50authorRonit Satchi-FainaroQ19758708
P2093author name stringDina Polyak
Anat Eldar-Boock
P2860cites workTargeting Tumor Vasculature: Reality or a Dream?Q57617360
Integrin-regulated FAK-Src signaling in normal and cancer cellsQ24300271
Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase NQ24317442
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicityQ24561642
Targeting selectins and selectin ligands in inflammation and cancerQ24658204
Tumor angiogenesis: therapeutic implicationsQ27860595
Integrins: bidirectional, allosteric signaling machinesQ27860700
Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrinsQ28202564
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatinQ28239719
Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesisQ28260742
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory targetQ28266775
Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancyQ28272747
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growthQ28323559
The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cellsQ28474747
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
Angiogenesis: an organizing principle for drug discovery?Q29614538
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeQ29616413
Angiogenesis as a therapeutic targetQ29619525
N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonistsQ30580638
Solution stability of linear vs. cyclic RGD peptidesQ30744942
An address system in the vasculature of normal tissues and tumorsQ30874647
Drug targeting to specific vascular sitesQ30883393
Specialization of tumour vasculatureQ30896811
Combinatorial discovery of tumor targeting peptides using phage displayQ31005417
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse modelQ32145219
Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrinsQ33289019
Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeuticsQ33432776
Hyaluronan: a multifunctional, megaDalton, stealth moleculeQ34026287
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastomaQ34066263
Families of zinc metalloproteases.Q34325403
RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivoQ34379366
VEGF receptor signal transductionQ34461939
The hyaluronan receptor, CD44.Q34598130
RNAi therapeutics: principles, prospects and challengesQ34621268
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationshipQ34690734
Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us.Q34693504
Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor modelsQ34770116
Regulation of the metastatic process by E-selectin and stress-activated protein kinase-2/p38.Q35027257
Selectins-an emerging target for drug delivery.Q35669922
CD13/APN is activated by angiogenic signals and is essential for capillary tube formationQ35751643
Anti-vascular tumor therapy: recent advances, pitfalls and clinical perspectivesQ35781708
CD13/APN regulates endothelial invasion and filopodia formationQ35850653
Integrin signalling during tumour progressionQ35906078
Polymer therapeutics: concepts and applicationsQ36380938
Mitochondria and cancer: Warburg addressedQ36547748
Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonismQ36611736
Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancerQ36667452
Peptides which bind to E-selectin and block neutrophil adhesionQ36679423
Endothelial cell adhesion molecules and cancer progressionQ36737909
The structure and main functions of aminopeptidase N.Q36754546
Dendrimers in oncology: an expanding horizonQ37355900
Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cellsQ37367187
Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxelQ37378199
Clustering and internalization of integrin alphavbeta3 with a tetrameric RGD-synthetic peptide.Q37383038
Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalencyQ37480688
Breast cancer: understanding sensitivity and resistance to chemotherapy and targeted therapies to aid in personalised medicine.Q37481556
Degradable polyethylenimines as DNA and small interfering RNA carriersQ37532552
Targetable HPMA copolymer-aminohexylgeldanamycin conjugates for prostate cancer therapyQ37635384
Small molecule integrin antagonists in cancer therapyQ37636249
HPMA copolymer-cyclic RGD conjugates for tumor targetingQ37642122
Hsp90: a drug target?Q37738758
The selectins and their ligandsQ38304052
Activity screening and structure-activity relationship of the hit compounds targeting APN/CD13.Q39679483
In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriersQ39715659
Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate.Q39717127
The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicinQ39789312
Tumor-endothelium cross talk blocks recruitment of neutrophils to endothelial cells: a novel mechanism of endothelial cell anergyQ39793034
E-selectin binding peptide-polymer-drug conjugates and their selective cytotoxicity against vascular endothelial cellsQ39806556
Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrierQ39826157
In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3.Q39919998
Selectins ligand decorated drug carriers for activated endothelial cell targetingQ39938034
Hyaluronic acid-polyethyleneimine conjugate for target specific intracellular delivery of siRNA.Q40005275
MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma researchQ40227151
Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cellsQ40288837
Nanoparticles for the optical imaging of tumor E-selectinQ40359393
Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulatorQ40532812
Syntheses and some applications of chemically defined multivalent glycoconjugatesQ41206802
Selectin-carbohydrate interactions during inflammation and metastasisQ41594933
Cracking the carbohydrate code for selectin recognitionQ41651480
Anti-cancer activity of targeted pro-apoptotic peptidesQ41688099
De novo antimicrobial peptides with low mammalian cell toxicityQ42810129
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological propertiesQ43597572
Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugatesQ43908844
Tumor regression by targeted gene delivery to the neovasculatureQ44044889
Fractionation and characterization of a conjugate between a polymeric drug-carrier and the antitumor drug camptothecinQ44222038
Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targetingQ44284738
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.Q44775111
Improved tumor targeting of radiolabeled RGD peptides using rapid dose fractionationQ45082801
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.Q45259478
PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: in vitro characterization and in vivo evaluation.Q46017742
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.Q46079015
Targeting bone metastases with a bispecific anticancer and antiangiogenic polymer-alendronate-taxane conjugateQ46084536
Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancerQ46507139
The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamineQ47582503
A mitochondrial targeted fusion peptide exhibits remarkable cytotoxicity.Q52573063
Phase III trial comparing paclitaxel poliglumex (CT-2103, PPX) in combination with carboplatin versus standard paclitaxel and carboplatin in the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer.Q53144257
Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.Q53686513
Development of PEGylated doxorubicin-E-[c(RGDfK)2] conjugate for integrin-targeted cancer therapyQ57617348
Rational Design of Multifunctional Polymer Therapeutics for Cancer TheranosticsQ57617355
P304page(s)591-625
P577publication date2011-12-16
P1476titleLigand-Assisted Vascular Targeting of Polymer Therapeutics

Reverse relations

Q47959735Integrin-targeted nano-sized polymeric systems for paclitaxel conjugation: a comparative study.cites workP2860

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