Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer

scholarly article by Tarek A Bismar et al published 19 January 2012 in Histopathology

Interactions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2559.2011.04116.X
P698PubMed publication ID22260502

P50authorJeremy A. SquireQ39802515
P2093author name stringMaisa Yoshimoto
Kanishka Sircar
Tarek A Bismar
Shuhong Liu
Qiuli Duan
P2860cites workPTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancerQ42473567
Is PTEN loss associated with clinical outcome measures in human prostate cancer?Q43249619
The assessment of PTEN tumor suppressor gene in combination with Gleason scoring and serum PSA to evaluate progression of prostate carcinoma.Q45876896
TMPRSS2-ERG fusion is frequently observed in Gleason pattern 3 prostate cancer in a Canadian cohortQ46231066
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancerQ47919199
TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort.Q54561352
Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression.Q54566910
Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancerQ57693470
TMPRSS2-ERG Fusion Prostate Cancer: An Early Molecular Event Associated With InvasionQ57693484
Current Thoughts on the Role of the Androgen Receptor and Prostate Cancer ProgressionQ57693532
Detection ofERGgene rearrangements andPTENdeletions in unsuspected prostate cancer of the transition zoneQ57790351
Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcomeQ57790493
The role of SPINK1 in ETS rearrangement-negative prostate cancersQ24647020
Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancerQ24650647
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.Q27851411
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasisQ33266259
Delineation of TMPRSS2-ERG splice variants in prostate cancerQ33357287
Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancerQ33359279
Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancerQ33723651
Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptorQ34595342
Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissuesQ34651198
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.Q34973214
Androgen receptor involvement in the progression of prostate cancerQ35147116
Regulation of androgen receptor levels: implications for prostate cancer progression and therapyQ36110677
FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded tissueQ36462723
Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancerQ36610777
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.Q36681101
Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancerQ37107560
Characterization of ETS gene aberrations in select histologic variants of prostate carcinomaQ37383449
Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progressionQ37383459
EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancerQ37408809
The role of androgen receptor mutations in prostate cancer progression.Q37590123
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostateQ39506775
Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancerQ39787898
TMPRSS2:ERG fusion identifies a subgroup of prostate cancers with a favorable prognosis.Q39976204
Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancerQ40236516
Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasiasQ40293372
Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancersQ40685677
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesisQ41778982
Predictive value of PTEN and AR coexpression of sustained responsiveness to hormonal therapy in prostate cancer--a pilot study.Q42072658
TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomyQ42145160
P433issue4
P921main subjectprostate cancerQ181257
P304page(s)645-652
P577publication date2012-01-19
P1433published inHistopathologyQ1524040
P1476titleInteractions and relationships of PTEN, ERG, SPINK1 and AR in castration-resistant prostate cancer
P478volume60

Reverse relations

cites work (P2860)
Q39457666A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cells.
Q38833458Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH.
Q57022565Association of ERG/PTEN status with biochemical recurrence after radical prostatectomy for clinically localized prostate cancer
Q38052382Caspase control: protagonists of cancer cell apoptosis
Q49818398Clinical implications of PTEN loss in prostate cancer
Q42184220Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer
Q38614981Cysteine- rich secretory protein 3 (CRISP3), ERG and PTEN define a molecular subtype of prostate cancer with implication to patients' prognosis
Q38774228DNA alterations in the tumor genome and their associations with clinical outcome in prostate cancer
Q38681610ERG expression in prostate cancer: biological relevance and clinical implication
Q50927287ERG protein expression and gene rearrangements are present at lower rates in metastatic and locally advanced castration-resistant prostate cancer compared to localized disease.
Q34205227Evidence for molecular differences in prostate cancer between African American and Caucasian men
Q38142173Genomic Rearrangements of PTEN in Prostate Cancer
Q27022288Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression
Q34365632Molecular pathways and targets in prostate cancer
Q36800086Molecular profiling of ETS and non-ETS aberrations in prostate cancer patients from northern India
Q53638595Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next-generation DNA sequencing.
Q39401816PTEN Loss as Determined by Clinical-grade Immunohistochemistry Assay Is Associated with Worse Recurrence-free Survival in Prostate Cancer
Q41907553PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas
Q42371556PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohort
Q51395627SPINK1 Overexpression in Localized Prostate Cancer: a Rare Event Inversely Associated with ERG Expression and Exclusive of Homozygous PTEN Deletion.
Q53644292SPINK1 expression in relation to PTEN and ERG in matched primary and lymph node metastatic prostate cancer: Implications for biomarker development.
Q48030483SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrence
Q34203149SPINK1 protein expression and prostate cancer progression
Q39016331Serine protease inhibitor Kazal type 1 promotes epithelial-mesenchymal transition through EGFR signaling pathway in prostate cancer
Q42782654The prognostic significance of combined ERG and androgen receptor expression in patients with prostate cancer managed by androgen deprivation therapy
Q37709925The role of intracrine androgen metabolism, androgen receptor and apoptosis in the survival and recurrence of prostate cancer during androgen deprivation therapy
Q38980564Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells.

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