Multimorbidity and functional impairment: bidirectional interplay, synergistic effects and common pathways

scientific article published on 22 November 2018

Multimorbidity and functional impairment: bidirectional interplay, synergistic effects and common pathways is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JOIM.12843
P932PMC publication ID6446236
P698PubMed publication ID30357990

P50authorAmaia Calderón-LarrañagaQ40282046
Stewart MercerQ59190596
Alessandra MarengoniQ59674155
Davide L VetranoQ64795910
P2093author name stringL Fratiglioni
L Ferrucci
M Eriksdotter
G Onder
P2860cites workPhysical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA-Age studyQ40280047
Effect of Chronic Diseases and Multimorbidity on Survival and Functioning in Elderly AdultsQ40287658
Commentary: Life course epidemiology embraces geroscience.Q40460342
Psychosocial patient characteristics and GP-registered chronic morbidity: a prospective study.Q40716678
Frailty and Drug Use.Q40736256
Multimorbidity, mortality, and physical activityQ40806120
Living Unnoticed: Cognitive Impairment in Older People with MultimorbidityQ40900862
Prevalence of Comorbidity in Patients With Young-Onset Alzheimer Disease Compared With Late-Onset: A Comparative Cohort StudyQ40969710
Geriatric conditions, rather than multimorbidity, as predictors of disability and mortality among octogenarians: A population-based cohort study.Q41021080
Psychosocial complexity in multimorbidity: the legacy of adverse childhood experiences.Q41031156
Cardiovascular Diseases in ~30,000 Patients in the Swedish Dementia RegistryQ41324336
Comorbidity, health status, and quality of life in institutionalized older people with and without dementiaQ43357366
Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study.Q44277894
Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health studyQ44641677
Influence of multimorbidity on cognition in a normal aging population: a 12-year follow-up in the Maastricht Aging Study.Q45308331
Can chronic multimorbidity explain the age-related differences in strength, speed and balance in older adults?Q45796141
Risk and protective factors for physical functioning in older adults with and without chronic conditions: MacArthur Studies of Successful AgingQ46577678
Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidenceQ46945219
New horizons in multimorbidity in older adultsQ47250291
The effect of multimorbidity on health related functioning: temporary or persistent? Results from a longitudinal cohort studyQ47318580
Adverse events of proton pump inhibitors: potential mechanismsQ47345315
Projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) modelQ47551895
Treatment of Atrial Fibrillation in Patients with Dementia: A Cohort Study from the Swedish Dementia RegistryQ47559889
The relationship between physical and mental health: A mediation analysis.Q47574927
The contribution of musculoskeletal disorders in multimorbidity: Implications for practice and policyQ47580180
The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity-the FINGER Randomized Controlled TrialQ47625353
What is the impact of physical activity and physical function on the development of Multimorbidity in older adults over time? A population based cohort studyQ47725328
Multimorbidity and Physical and Cognitive Function: Performance of a New Multimorbidity-Weighted Index.Q47827560
Guidelines, polypharmacy, and drug-drug interactions in patients with multimorbidityQ48098575
Anticholinergic burden and health outcomes among older adults discharged from hospital: results from the CRIME study.Q48308894
Aging, inflammation and the environment.Q49595178
Multimorbidity and quality of life at mid-life: A systematic review of general population studies.Q49919434
Combined Associations of Muscle-Strengthening Activities and Accelerometer-Assessed Physical Activity on Multimorbidity: Findings From NHANES.Q40145833
Effects of Mobility and Multimorbidity on Inpatient and Post-Acute Health Care UtilizationQ40147861
Defining comorbidity: implications for understanding health and health servicesQ24647220
Predicting declines in physical function in persons with multiple chronic medical conditions: what we can learn from the medical problem listQ24795204
Ill or just old? Towards a conceptual framework of the relation between ageing and diseaseQ24805193
Prevalence, determinants and patterns of multimorbidity in primary care: a systematic review of observational studiesQ26852275
Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical TrialQ28049690
Mechanisms of development of multimorbidity in the elderlyQ28084171
Frailty in older adults: evidence for a phenotypeQ28205094
Association of Cardiometabolic Multimorbidity With MortalityQ28606934
Multimorbidity and mortality in older adults: A systematic review and meta-analysis.Q30248582
'Multimorbidity' as the manifestation of network disturbances.Q30390588
A claims data-based comparison of comorbidity in individuals with and without dementiaQ30570359
Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditionsQ30995042
Time Trends in Prevalence of Chronic Diseases and Multimorbidity Not Only due to Aging: Data from General Practices and Health SurveysQ31119117
Antidepressants and mortality risk in a dementia cohort: data from SveDem, the Swedish Dementia RegistryQ31126232
Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data.Q31160667
Medication errors in elderly people: contributing factors and future perspectivesQ33481157
Loss of Weight in Obese Older Adults: A Biomarker of Impending Expansion of Multimorbidity?Q33557003
Multimorbidity, disability, and mortality in community-dwelling older adultsQ33609489
Comorbidity and progression of late onset Alzheimer's disease: A systematic reviewQ33638042
The impact of socioeconomic status and multimorbidity on mortality: a population-based cohort studyQ33704020
Multimorbidity and long-term care dependency--a five-year follow-upQ33713227
The influence of socioeconomic deprivation on multimorbidity at different ages: a cross-sectional studyQ33815883
How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age?Q33831749
Relationship of subjective cognitive impairment and cognitive impairment no dementia to chronic disease and multimorbidity in a nation-wide twin studyQ33836211
Long-term effects of intensive glucose lowering on cardiovascular outcomesQ33851861
Incidence and predictors of multimorbidity in the elderly: a population-based longitudinal studyQ33945995
Comorbidity in dementia: update of an ongoing autopsy studyQ34232778
Comorbidity of dementia: a cross-sectional study of primary care older patientsQ34410870
Impact of multimorbidity on disability and quality of life in the Spanish older populationQ34465243
Socioeconomic status and multimorbidity: a systematic review and meta-analysisQ50015851
Rapidly developing multimorbidity and disability in older adults: does social background matter?Q50055255
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.Q50578805
Comorbidity and multimorbidity need to be placed in the context of a framework of risk, responsiveness, and vulnerability.Q50692797
Identifying subgroups of complex patients with cluster analysis.Q50790133
High levels of comorbidity and disability cancel out the dementia effect in predictions of long-term mortality after discharge in the very old.Q51005435
Implications of comorbidity on costs for patients with Alzheimer disease.Q51119991
Contributions of environment, comorbidity, and stage of dementia to the onset of walking and eating disability in long-term care residents.Q51322586
Accounting for frailty when treating chronic diseases.Q51764230
Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish cohort study.Q51765490
Treating nondementia illnesses in patients with dementia.Q51976512
Multimorbidity and Functional Limitation in Individuals with Heart Failure: A Prospective Community Study.Q52617375
Physical Functioning Decline and Mortality in Older Adults with Multimorbidity: Joint Modeling of Longitudinal and Survival Data.Q52660698
An epigenetic biomarker of aging for lifespan and healthspan.Q52717952
Understanding adverse drug reactions in older adults through drug-drug interactions.Q53082927
Defining Health Trajectories in Older Adults With Five Clinical Indicators.Q53348094
Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe.Q53588448
Participation in muscle-strengthening activities as an alternative method for the prevention of multimorbidity.Q53828350
Prevalence of disability according to multimorbidity and disease clustering: a population-based study.Q55184514
Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach.Q55645338
In an exploratory prospective study on multimorbidity general and disease-related susceptibility could be distinguishedQ57950021
A Prescribing Cascade Involving Cholinesterase Inhibitors and Anticholinergic DrugsQ58070614
High Prevalence of Poor Quality Drug Prescribing in Older Individuals: A Nationwide Report From the Italian Medicines Agency (AIFA)Q58946247
The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal studyQ62565960
Comorbidity of somatic chronic diseases and decline in physical functioning:; the Longitudinal Aging Study AmsterdamQ79773376
Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapyQ87967193
Medical Comorbidity in Alzheimer's Disease: A Nested Case-Control StudyQ88374064
Frailty and Multimorbidity: A Systematic Review and Meta-analysisQ88568815
Association of Polypharmacy With 1-Year Trajectories of Cognitive and Physical Function in Nursing Home Residents: Results From a Multicenter European StudyQ88964603
Association between Weight Change and Mortality in Community Living Older People Followed for Up to 14 Years. The Hordaland Health Study (HUSK)Q89130905
Predicting Incident MultimorbidityQ89480887
Double trouble: the impact of multimorbidity and deprivation on preference-weighted health related quality of life a cross sectional analysis of the Scottish Health Survey.Q37151972
High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging.Q37174882
Recovery of activities of daily living in older adults after hospitalization for acute medical illnessQ37280618
Multimorbidity and Functional Limitations Among Adults 65 or Older, NHANES 2005-2012.Q37392312
Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical ResearchQ37445303
Association of comorbidity and health service usage among patients with dementia in the UK: a population-based studyQ37704238
Aging with multimorbidity: a systematic review of the literatureQ37852847
Non-psychiatric comorbidity associated with Alzheimer's disease.Q37902373
Cumulative complexity: a functional, patient-centered model of patient complexity can improve research and practiceQ38036535
Multimorbidity and functional status in community-dwelling older adults.Q38226568
A major role for cardiovascular burden in age-related cognitive declineQ38316448
Cardiovascular Events in a Physical Activity Intervention Compared With a Successful Aging Intervention: The LIFE Study Randomized TrialQ38389884
High Symptom Burden and Low Functional Status in the Setting of MultimorbidityQ38600686
Multimorbidity, dementia and health care in older people:a population-based cohort studyQ38623214
The contribution of risk factors to socioeconomic inequalities in multimorbidity across the lifecourse: a longitudinal analysis of the Twenty-07 cohort.Q38638019
Social prescribing: less rhetoric and more reality. A systematic review of the evidenceQ38733352
Prospective Disability in Different Combinations of Somatic and Mental Multimorbidity.Q38765559
Defeating Alzheimer's disease and other dementias: a priority for European science and societyQ38778638
Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men: The Concord Health and Ageing in Men ProjectQ38785484
Dementia, Comorbidity, and Physical Function in the Program of All-Inclusive Care for the Elderly.Q38823013
Metformin as a Tool to Target AgingQ38865781
Increasing Trajectories of Multimorbidity Over Time: Birth Cohort Differences and the Role of Changes in Obesity and IncomeQ38960226
Physical Activity and the Effect of Multimorbidity on All-Cause Mortality in Older AdultsQ38979217
Multimorbidity patterns are differentially associated with functional ability and decline in a longitudinal cohort of older womenQ38980015
Geroscience: Addressing the mismatch between its exciting research opportunities, its economic imperative and its current funding crisisQ39015871
Reverse geroscience: how does exposure to early diseases accelerate the age-related decline in health?Q39025975
NSAIDs for Chronic Low Back PainQ39154326
The epigenetic landscape of age-related diseases: the geroscience perspectiveQ39206184
Association Between Lifestyle Factors and the Incidence of Multimorbidity in an Older English Population.Q39548167
Association between body mass index and prevalence of multimorbidity: a cross-sectional studyQ39658173
Concurrence of Frailty and Parkinson's DiseaseQ39669230
Handgrip strength is inversely and independently associated with multimorbidity among older women: Results from the KORA-Age studyQ39827311
The association between chronic illness, multimorbidity and depressive symptoms in an Australian primary care cohortQ39964374
Associations between bouted and non-bouted physical activity on multimorbidityQ39968085
Comorbidity and dementia: a scoping review of the literature.Q34499517
Trends in Prescription Drug Use Among Adults in the United States From 1999-2012.Q34500310
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioningQ34505808
Changes in Weight at the End of Life: Characterizing Weight Loss by Time to Death in a Cohort Study of Older MenQ34514225
Association between physical activity, multimorbidity, self-rated health and functional limitation in the Spanish populationQ34565396
Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trialQ34701688
Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkersQ34974747
A systematic review of intervention studies to prevent hospitalizations of community-dwelling older adults with dementiaQ35027312
Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicityQ35065283
Age-related variation in health status after age 60.Q35143927
Frailty and respiratory impairment in older persons.Q35634463
The impact of multimorbidity on adult physical and mental health in low- and middle-income countries: what does the study on global ageing and adult health (SAGE) reveal?Q35736354
Multimorbidity and functional decline in community-dwelling adults: a systematic reviewQ35807364
Inflammation Partially Mediates the Association of Multimorbidity and Functional Limitations in a National Sample of Middle-Aged and Older Adults: The MIDUS StudyQ35842143
A systematic review of prevalence studies on multimorbidity: toward a more uniform methodologyQ35860109
The CARE Plus study - a whole-system intervention to improve quality of life of primary care patients with multimorbidity in areas of high socioeconomic deprivation: exploratory cluster randomised controlled trial and cost-utility analysisQ36058203
Multimorbidity and Risk of Mild Cognitive ImpairmentQ36165338
Energy Metabolism and the Burden of Multimorbidity in Older Adults: Results From the Baltimore Longitudinal Study of AgingQ36181490
Optimising drug treatment for elderly people: the prescribing cascadeQ36246842
Multimorbidity and healthcare utilization among home care clients with dementia in Ontario, Canada: A retrospective analysis of a population-based cohort.Q36299510
Medical generalists: connecting the map and the territoryQ36343071
Definitions and predictors of successful aging: a comprehensive review of larger quantitative studiesQ36366191
Long terms trends of multimorbidity and association with physical activity in older English populationQ36476256
The effect of experimentally induced sedentariness on mood and psychobiological responses to mental stressQ36633003
The effect of physical multimorbidity, mental health conditions and socioeconomic deprivation on unplanned admissions to hospital: a retrospective cohort studyQ36698657
Association of handgrip strength with chronic diseases and multimorbidity: a cross-sectional studyQ36795260
Combinations of Chronic Conditions, Functional Limitations, and Geriatric Syndromes that Predict Health OutcomesQ36910101
Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without DementiaQ36940694
Multimorbidity Combinations and Disability in Older AdultsQ36954943
Multimorbidity and neuroimaging biomarkers among cognitively normal personsQ36963306
A High Sense of Coherence as Protection Against Adverse Health Outcomes in Patients Aged 80 Years and Older.Q37084055
Report of the national institute on aging task force on comorbidityQ37104285
Impact of physical function impairment and multimorbidity on mortality among community-living older persons with sarcopaenia: results from the ilSIRENTE prospective cohort studyQ37134141
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectMultimorbidityQ61911678
P304page(s)255-271
P577publication date2018-11-22
P1433published inJournal of Internal MedicineQ6295387
P1476titleMultimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways
P478volume285

Reverse relations

cites work (P2860)
Q92460759Association Between Multimorbidity and Depressive Symptom Among Community-Dwelling Elders in Eastern China
Q92819205Associations between complex multimorbidity, activities of daily living and mortality among older Norwegians. A prospective cohort study: the HUNT Study, Norway
Q99417838Cluster Analysis of the Associations among Physical Frailty, Cognitive Impairment and Mental Disorders
Q91975677Development of a Healthy Lifestyle Assessment Toolkit for the General Public
Q97530300Diurnal patterns of sedentary behavior and changes in physical function over time among older women: a prospective cohort study
Q90567536Do Older Adults with Multimorbidity Meet the Recommended Levels of Physical Activity? An Analysis of Scottish Health Survey
Q89656178Frailty and cognitive decline
Q99248482How to improve care for patients with RA and comorbidities
Q92977564Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM
Q90450944Psychological correlates of multimorbidity and disability accumulation in older adults
Q92316580Sarcopenia, long-term conditions, and multimorbidity: findings from UK Biobank participants
Q96765418Twelve-year clinical trajectories of multimorbidity in a population of older adults

Search more.