FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops.

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FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops. is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.01146-18
P932PMC publication ID6325234
P698PubMed publication ID30348662

P50authorMichele BonusQ58661904
Erwin LampingQ64008617
Richard CannonQ42745521
P2093author name stringLutz Schmitt
Holger Gohlke
Kyoko Niimi
Masakazu Niimi
Koichi Tanabe
Ariya Chindamporn
Minoru Nagi
Kunji Miyoshi
Susumu Tomiyama
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Functional impact of a single mutation within the transmembrane domain of the multidrug ABC transporter Pdr5.Q43574790
Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters.Q44606676
Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.Q44931220
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Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients.Q51180154
Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity.Q53750874
The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility.Q54059367
Chimeras of Candida albicans Cdr1p and Cdr2p reveal features of pleiotropic drug resistance transporter structure and functionQ84898935
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Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiaeQ35947069
Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolatesQ36095337
Dual action antifungal small molecule modulates multidrug efflux and TOR signalingQ36116026
An update on antifungal targets and mechanisms of resistance in Candida albicansQ36235037
A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.Q36516207
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Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transportQ37000251
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The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycleQ37234052
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Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of PolyspecificityQ37591245
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Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping propertiesQ38362728
An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormonesQ41183764
Structure of the human multidrug transporter ABCG2.Q41597764
Chemosensitization as a means to augment commercial antifungal agentsQ42141903
Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.Q42563449
Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.Q42676608
Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetricQ42745431
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
transmembrane proteinQ424204
Saccharomyces cerevisiaeQ719725
P577publication date2018-12-21
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleFK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops.
P478volume63

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cites work (P2860)
Q92921364Candida albicans Antifungal Resistance and Tolerance in Bloodstream Infections: The Triad Yeast-Host-Antifungal
Q58597565as a Model Host to Monitor the Infection Processes

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