A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

scientific article published on 18 October 2018

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CMET.2018.09.021
P932PMC publication ID6370946
P698PubMed publication ID30344016

P50authorJulia B CorderoQ42408240
Daniel J MurphyQ47112024
Oliver D K MaddocksQ80053782
P2093author name stringMarcos Vidal
Tong Zhang
Alessandro Scopelliti
Björn Kruspig
Christin Bauer
Yachuan Yu
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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signalingQ24307371
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signallingQ24310750
Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2Q24556617
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingQ24794823
Neural control of energy balance: translating circuits to therapiesQ27005992
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Nutritional regulation of stem and progenitor cells in DrosophilaQ27026694
p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretionQ27312065
A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretionQ27314498
Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreadingQ28270965
Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipaseQ28290378
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesityQ28303894
Dual lipolytic control of body fat storage and mobilization in DrosophilaQ28469201
Molecular evolution and functional characterization of Drosophila insulin-like peptidesQ33535892
Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgutQ33713922
Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel lociQ33864624
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1.Q34084120
Gut feelings: the emerging biology of gut-brain communicationQ34199959
Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogasterQ34644582
Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathwayQ35558600
Altered modes of stem cell division drive adaptive intestinal growthQ35633862
Intestinal nutrient sensing and blood glucose controlQ35639664
Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosisQ35715738
GPR48 increases mineralocorticoid receptor gene expressionQ35715750
A novel approach for directing transgene expression in Drosophila: T2A-Gal4 in-frame fusionQ35810786
Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of DrosophilaQ35863060
Mapping neural circuits with activity-dependent nuclear import of a transcription factorQ35978818
Energy Homeostasis Control in Drosophila Adipokinetic Hormone MutantsQ36132326
Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.Q36579419
Role of fat body lipogenesis in protection against the effects of caloric overload in DrosophilaQ36708470
A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine CellsQ36835395
Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β.Q37068117
Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell deathQ37156370
Promoting longevity by maintaining metabolic and proliferative homeostasisQ37402142
Systemic Activin signaling independently regulates sugar homeostasis, cellular metabolism, and pH balance in Drosophila melanogasterQ37711961
Bowels control brain: gut hormones and obesityQ37768338
Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptidesQ37849883
The contribution of the Drosophila model to lipid droplet researchQ37881206
Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humansQ37976164
Diet: friend or foe of enteroendocrine cells--how it interacts with enteroendocrine cellsQ37983846
The digestive tract of Drosophila melanogasterQ38135489
Enteroendocrine Cells: Chemosensors in the Intestinal EpitheliumQ38600658
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell ActivityQ38689227
Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in DrosophilaQ38697788
Modulating the therapeutic response of tumours to dietary serine and glycine starvationQ38706796
Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA.Q38997285
Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.Q40074896
Association of a gain-of-function variant in LGR4 with central obesityQ40437811
Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut.Q41121635
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgutQ42077813
Correction: Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size RegulationQ42399702
PERILIPIN-dependent control of lipid droplet structure and fat storage in DrosophilaQ42479119
A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasisQ42561128
Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.Q42652628
Control of lipid metabolism by tachykinin in Drosophila.Q43144399
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypesQ43988822
Bursicon-expressing neurons undergo apoptosis after adult ecdysis in the mosquito Anopheles gambiaeQ44158027
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traitsQ44274525
Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cellsQ45062201
A gut feeling for obesity: 7TM sensors on enteroendocrine cellsQ46223313
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switchQ46519761
Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signalingQ46658335
A nutrient sensor mechanism controls Drosophila growth.Q47070296
Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptidesQ47070356
Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.Q47070881
Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral programQ47072239
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth controlQ47072375
The genetic variant Voila causes gustatory defects during Drosophila development.Q47072554
A single-cell survey of the small intestinal epitheliumQ47564808
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogasterQ47947920
Transsynaptic Mapping of Second-Order Taste Neurons in Flies by trans-TangoQ47984553
Regulation of Carbohydrate Energy Metabolism in Drosophila melanogasterQ48047337
Remote control of insulin secretion by fat cells in DrosophilaQ48469973
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in DrosophilaQ48512148
Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic ControlQ49727393
Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditionsQ50319780
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretionQ50336270
Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system.Q52173287
Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine.Q52723821
Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR.Q52731178
Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.Q52840819
A subset of enteroendocrine cells is activated by amino acids in the Drosophila midgut.Q52841981
G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract.Q54449426
THADA Regulates the Organismal Balance between Energy Storage and Heat ProductionQ58374814
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectBursiconQ5000609
P304page(s)269-284.e10
P577publication date2018-10-18
P1433published inCell MetabolismQ1254684
P1476titleA Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila
P478volume29

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cites work (P2860)
Q64066399Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila
Q101051403Enteric neurons increase maternal food intake during reproduction
Q92525268Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation
Q92452494The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions

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