Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3

scientific article published on 31 July 2018

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 is …
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scholarly articleQ13442814

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P5530Altmetric DOI10.1128/JVI.00477-18
P6179Dimensions Publication ID1104384605
P356DOI10.1128/JVI.00477-18
P953full work available at URLhttp://eprints.whiterose.ac.uk/132033
P932PMC publication ID6069192
P698PubMed publication ID29875241
P1154Scopus EID2-s2.0-85050826554

P50authorRoland RemenyiQ56424001
Carsten ZothnerQ56424003
Ruth E HughesQ56424624
Alistair CurdQ89005220
Yanni GaoQ89013543
Andres MeritsQ24546306
Michelle PeckhamQ41530215
Mark HarrisQ39050665
P2093author name stringAndres Merits
Yanni Gao
Carsten Zothner
Alistair Curd
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The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last.Q52370659
The alphavirus replicase protein nsP1 is membrane-associated and has affinity to endocytic organellesQ72230141
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Post-chikungunya chronic inflammatory rheumatism: results from a retrospective follow-up study of 283 adult and child cases in La Virginia, Risaralda, ColombiaQ24288818
Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophagesQ24288996
Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signalingQ24594497
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase IIQ24619991
Stress granules and processing bodies are dynamically linked sites of mRNP remodelingQ24678779
Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictusQ24701749
Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Q24701750
Multiple immune factors are involved in controlling acute and chronic chikungunya virus infectionQ24701792
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Formation of nsP3-Specific Protein Complexes during Sindbis Virus ReplicationQ27473143
Alphavirus RNA replicase is located on the cytoplasmic surface of endosomes and lysosomesQ27482419
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ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.Q27936710
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillizationQ28588090
ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulenceQ28595102
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Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formationQ30009233
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Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infectionQ30009987
Chikungunya virus nsP3 blocks stress granule assembly by recruitment of G3BP into cytoplasmic fociQ30010040
Large G3BP-induced granules trigger eIF2α phosphorylationQ30010041
SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replicationQ30010201
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Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replicationQ30390208
Phosphatidylinositol 3-kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified lysosomesQ30495294
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Human muscle satellite cells as targets of Chikungunya virus infectionQ21562321
Differential proteome analysis of Chikungunya virus-infected new-born mice tissues reveal implication of stress, inflammatory and apoptotic pathways in disease pathogenesisQ39562528
Chikungunya virus mobilizes the apoptotic machinery to invade host cell defensesQ39649864
Functional Sindbis virus replicative complexes are formed at the plasma membraneQ39657845
Different types of nsP3-containing protein complexes in Sindbis virus-infected cellsQ39953345
Development of a new noncytopathic Semliki Forest virus vector providing high expression levels and stability.Q39987488
Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinaseQ40051185
SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence MicroscopyQ40117732
Mobility analysis of an NS5A-GFP fusion protein in cells actively replicating hepatitis C virus subgenomic RNA.Q40179334
Self-labelling enzymes as universal tags for fluorescence microscopy, super-resolution microscopy and electron microscopyQ40235844
Tracking and elucidating alphavirus-host protein interactionsQ40245922
The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolasesQ40354602
A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.Q40457206
Novel functions of the alphavirus nonstructural protein nsP3 C-terminal regionQ33648981
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulationQ33911149
Short-lived minus-strand polymerase for Semliki Forest virus.Q33917679
Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune responseQ34110965
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Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune responseQ34378105
Properly folded nonstructural polyprotein directs the semliki forest virus replication complex to the endosomal compartmentQ34466494
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Granulostasis: Protein Quality Control of RNP GranulesQ34555053
Infectious clones of Chikungunya virus (La Réunion isolate) for vector competence studiesQ34594476
Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunityQ34927480
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Cytoplasmic Structures Associated with an Arbovirus Infection: Loci of Viral Ribonucleic Acid SynthesisQ37125344
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Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex AssemblyQ38704984
Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activityQ38728306
Correlative light and electron microscopy enables viral replication studies at the ultrastructural levelQ38881860
How many patients with post-chikungunya chronic inflammatory rheumatism can we expect in the new endemic areas of Latin America?Q38999094
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
virologyQ7215
chikungunyaQ243257
Chikungunya virusQ15794049
P577publication date2018-07-31
P1433published inJournal of VirologyQ1251128
P859sponsorSuper resolution imaging of protein dynamics and functions in physiology and diseaseQ63346675
P1476titlePersistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3
P478volume92

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cites work (P2860)
Q104800078Deciphering the human cellular interactors of alphavirus unique domain of Chikungunya Virus
Q57468042Differences between acute and chronic stress granules, and how these differences may impact function in human disease
Q61819163Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription.
Q64267714On-demand Labeling of SNAP-tagged Viral Protein for Pulse-Chase Imaging, Quench-Pulse-Chase Imaging, and Nanoscopy-based Inspection of Cell Lysates
Q90051691Palmitoylated cysteines in Chikungunya virus nsP1 are critical for targeting to cholesterol-rich plasma membrane microdomains with functional consequences for viral genome replication
Q93087252Rheumatic manifestations of chikungunya: emerging concepts and interventions
Q59350362The host DHX9 DExH Box helicase is recruited to Chikungunya virus replication complexes for optimal genomic RNA translation

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