Myeloid Dendritic Cells Induce HIV Latency in Proliferating CD4 T Cells

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Myeloid Dendritic Cells Induce HIV Latency in Proliferating CD4 T Cells is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1701233
P932PMC publication ID6103814
P698PubMed publication ID30030324

P50authorRachel PascoeQ58910611
Paul Urquhart CameronQ67957474
Renee M van der SluisQ37369246
Sharon R. LewinQ37618308
P2093author name stringVanessa A Evans
Nitasha A Kumar
Talia Mota
P2860cites workCell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infectionQ22251080
Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathwayQ24523390
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsQ24534904
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIVQ24567990
HIV restriction in quiescent CD4⁺ T cellsQ26995784
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phasesQ28237805
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.Q30515733
HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage responseQ33508241
Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infectionsQ33573749
Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene regionQ33805553
Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapyQ33816010
Vpr-host interactions during HIV-1 viral life cycleQ33828332
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeysQ34020988
Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cellsQ34059612
Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuliQ34124009
Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton.Q34165677
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activationQ34331884
The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrestQ34480135
HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infectionQ34502840
HIV infection and the gastrointestinal immune systemQ34601874
TIM-3 does not act as a receptor for galectin-9.Q34649690
Dendritic cell-induced activation of latent HIV-1 provirus in actively proliferating primary T lymphocytesQ34649701
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsQ34672568
An in vitro system to model the establishment and reactivation of HIV-1 latency.Q51960585
CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.Q51971372
A novel in vitro system to generate and study latently HIV-infected long-lived normal CD4+ T-lymphocytes.Q51980078
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.Q52007779
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
The pathway to establishing HIV latency is critical to how latency is maintained and reversed.Q54237426
Identification of two binding sites in staphylococcal enterotoxin B that confer specificity for TCR Vβ gene productsQ56797391
Programmed cell death-1 contributes to the establishment and maintenance of HIV-1 latencyQ58003757
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T CellsQ88866382
Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cellsQ34699537
Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cellsQ35067224
HIV-1 integration landscape during latent and active infectionQ35211469
Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanomaQ35822484
The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4(+) T-cellsQ36053889
Dendritic cells are potent antigen-presenting cells for microbial superantigensQ36230868
Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cellsQ36287580
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoirQ36318184
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responsesQ36362098
Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cellsQ36404256
p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cellsQ36434375
Identification of T cell-signaling pathways that stimulate latent HIV in primary cellsQ36690000
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cellsQ37039142
CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failureQ37059664
High levels of CD2 expression identify HIV-1 latently infected resting memory CD4+ T cells in virally suppressed subjects.Q37123276
Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.Q37493334
HIV DNA subspecies persist in both activated and resting memory CD4+ T cells during antiretroviral therapyQ37643783
Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infectionQ37700859
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamicsQ37737052
Origins of CD4(+) effector and central memory T cellsQ37899115
Molecular signatures of T-cell inhibition in HIV-1 infectionQ38091548
CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytesQ38889611
Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB.Q39026635
A novel mechanism for HIV1-mediated bystander CD4+ T-cell death: neighboring dying cells drive the capacity of HIV1 to kill noncycling primary CD4+ T cells.Q39170271
Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restrictionQ39712159
Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cellsQ39810780
Early antiretroviral therapy with raltegravir generates sustained reductions in HIV reservoirs but not lower T-cell activation levelsQ41456104
Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T CellsQ41670052
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.Q41880147
Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in childrenQ42245629
CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latencyQ42573954
Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes.Q43154827
Functional antigen-independent synapses formed between T cells and dendritic cellsQ43740483
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).Q45745522
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
dendritic cellQ506253
P304page(s)1468-1477
P577publication date2018-07-20
P1433published inJournal of ImmunologyQ3521441
P1476titleMyeloid Dendritic Cells Induce HIV Latency in Proliferating CD4+ T Cells
P478volume201

Reverse relations

cites work (P2860)
Q89935915Diverse effects of interferon alpha on the establishment and reversal of HIV latency
Q91593126HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread
Q92479178Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection
Q64985976Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir.
Q90479627Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy
Q92441659Role of Dendritic Cells in Exposing Latent HIV-1 for the Kill
Q92216465Strength of T cell signaling regulates HIV-1 replication and establishment of latency

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