Clostridium difficile infection in Europe: a hospital-based survey

scientific article published in The Lancet

Clostridium difficile infection in Europe: a hospital-based survey is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0140-6736(10)61266-4
P698PubMed publication ID21084111

P50authorMark H. WilcoxQ47356567
Hanna PituchQ47543265
Fidelma FitzpatrickQ56419794
Ed J KuijperQ56419795
Maja RupnikQ61190280
P2093author name stringDominique L Monnet
Jaap T van Dissel
Birgit H B van Benthem
Martijn P Bauer
Mark H Wilcox
Jon S Brazier
Daan W Notermans
Birgit HB van Benthem
P2860cites workAPACHE II: a severity of disease classification systemQ29547729
Clostridium difficile infection: new developments in epidemiology and pathogenesisQ29615330
Clostridium difficile ribotype 027, toxinotype III, the NetherlandsQ33243642
Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficileQ33901190
PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes.Q33958794
Outpatient antibiotic use in Europe and association with resistance: a cross-national database studyQ34393751
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortalityQ34472139
An epidemic, toxin gene-variant strain of Clostridium difficileQ34472146
Fulminant Clostridium difficile colitis: patterns of care and predictors of mortality.Q34607848
Clostridium difficile--more difficult than everQ34868743
Emergence of Clostridium difficile-associated disease in North America and Europe.Q36590739
Toxinotype V Clostridium difficile in humans and food animalsQ37070485
Clinical risk factors for severe Clostridium difficile-associated diseaseQ37189496
Hospitalizations and deaths associated with Clostridium difficile infection, Finland, 1996-2004.Q37203760
Clostridium difficile in retail meat products, USA, 2007Q37203800
A novel toxinotyping scheme and correlation of toxinotypes with serogroups of Clostridium difficile isolates.Q39554772
Characteristics and incidence of Clostridium difficile-associated disease in The Netherlands, 2005.Q40166294
Clostridium difficile in discharged inpatients, GermanyQ42611280
Clostridium difficile PCR ribotype 078 toxinotype V found in diarrhoeal pigs identical to isolates from affected humans.Q43725125
Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile diseaseQ44074819
Prevalence of Clostridium difficile in diarrhoeic and non-diarrhoeic piglets.Q44212274
A European survey of diagnostic methods and testing protocols for Clostridium difficileQ44655220
European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI).Q45205659
Clostridium difficile ribotypes 027 and 106: clinical outcomes and risk factorsQ46040575
Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078.Q46353482
Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, CanadaQ46486664
Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, CanadaQ46943788
Recommendations for surveillance of Clostridium difficile-associated diseaseQ48920404
Rates of Clostridium difficile infection in patients discharged from Spanish hospitals, 1997-2005.Q51120282
Simulation study of confounder-selection strategies.Q52884423
Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and EuropeQ58924160
Spread and Epidemiology of Clostridium difficile Polymerase Chain Reaction Ribotype 027/Toxinotype III in The NetherlandsQ59361760
Prospective study of Clostridium difficile infections in Europe with phenotypic and genotypic characterisation of the isolatesQ59688382
Risk factors for severity and relapse of pseudomembranous colitis in an elderly populationQ79560787
P433issue9759
P407language of work or nameEnglishQ1860
P921main subjectClostridium difficileQ310543
P304page(s)63-73
P577publication date2011-01-01
P1433published inThe LancetQ939416
P1476titleClostridium difficile infection in Europe: a hospital-based survey
P478volume377

Reverse relations

cites work (P2860)
Q632300542019 update of the WSES guidelines for management of () infection in surgical patients
Q36091394A Canadian Working Group report on fecal microbial therapy: microbial ecosystems therapeutics
Q27335693A Comparison of Current Guidelines of Five International Societies on Clostridium difficile Infection Management.
Q92642001A Complex Scenario of Nonsteroidal Anti-inflammatory Drugs Induced Prostaglandin E2 Production and Gut Microbiota Alteration in Clostridium difficile-Infected Mice
Q92267912A Phase 2 Study Evaluating the Safety, Tolerability, and Immunogenicity of Two 3-Dose Regimens of a Clostridium difficile Vaccine in Healthy US Adults Aged 65 to 85 Years
Q64104118A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated PCR Ribotype 078
Q36255845A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters
Q42228641A cluster of fulminant Clostridium difficile colitis in an intensive care unit in Italy
Q92152991A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network
Q41434690A mixture of functionally oligoclonal humanized monoclonal antibodies that neutralize Clostridium difficile TcdA and TcdB with high levels of in vitro potency shows in vivo protection in a hamster infection model.
Q40185692A multicenter, retrospective, case-cohort study of the epidemiology and risk factors for Clostridium difficile infection among cord blood transplant recipients.
Q34257705A multicentre randomised controlled trial evaluating lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea in older people admitted to hospital: the PLACIDE study protocol.
Q92951993A phase 1 randomized study assessing safety and immunogenicity of two 3-dose regimens of a Clostridium difficile vaccine in healthy older Japanese adults
Q39906601A phase 1, placebo-controlled, randomized study of the safety, tolerability, and immunogenicity of a Clostridium difficile vaccine administered with or without aluminum hydroxide in healthy adults
Q26823599Acid suppression and the risk of Clostridium difficile infection
Q58556398Activates Human Mucosal-Associated Invariant T Cells
Q92578798Adaptation of host transmission cycle during Clostridium difficile speciation
Q39347528Adherence to clinical practice guidelines for the management of Clostridium difficile infection in Japan: a multicenter retrospective study
Q99207543Advanced age and increased CRP concentration are independent risk factors associated with Clostridioides difficile infection mortality
Q40723890Age and gender differences in Clostridium difficile-related hospitalization trends in Madrid (Spain) over a 12-year period.
Q42279664All-cause and disease-specific mortality in hospitalized patients with Clostridium difficile infection: a multicenter cohort study
Q26778130An Update on Clostridium difficile Toxinotyping
Q35598962An enhanced DNA fingerprinting service to investigate potential Clostridium difficile infection case clusters sharing the same PCR ribotype
Q38844052An exploratory study to evaluate Clostridium difficile polymerase chain reaction ribotypes and infection outcomes
Q95576106An in silico survey of Clostridioides difficile extrachromosomal elements
Q37992487An overview of the diagnosis and management of Clostridium difficile infection
Q34322185Analysis of a Clostridium difficile PCR ribotype 078 100 kilobase island reveals the presence of a novel transposon, Tn6164
Q42288669Analysis of metronidazole susceptibility in different Clostridium difficile PCR ribotypes
Q38208794Antibodies for treatment of Clostridium difficile infection
Q42274443Antimicrobial activity of LFF571 and three treatment agents against Clostridium difficile isolates collected for a pan-European survey in 2008: clinical and therapeutic implications
Q36835352Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078.
Q50157269Assessing the burden of C. difficile infection in low- and middle-income countries
Q38635793Association between omeprazole use and Clostridium difficile infection among hospitalized patients: A case-control study of the Saudi population
Q42280606Automated detection of toxigenic Clostridium difficile in clinical samples: isothermal tcdB amplification coupled to array-based detection
Q36571896Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo
Q58780929Bacteriophages Contribute to Shaping Species
Q59126532Bezlotoxumab Is Associated With a Reduction in Cumulative Inpatient-Days: Analysis of the Hospitalization Data From the MODIFY I and II Clinical Trials
Q51740247Bezlotoxumab for prevention of recurrent C. difficile infection in patients at increased risk for recurrence.
Q35106011Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling
Q35692352Burden of Clostridium difficile infection between 2010 and 2013: Trends and outcomes from an academic center in Eastern Europe
Q30196898Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes
Q45143059C. difficile ribotype 027 or 176?
Q37125211Challenges for standardization of Clostridium difficile typing methods
Q34510386Characterisation of Clostridium difficile biofilm formation, a role for Spo0A.
Q38837163Characterisation of Clostridium difficile strains isolated from Groote Schuur Hospital, Cape Town, South Africa
Q36996846Characterization of Clostridium difficile Strains in British Columbia, Canada: A Shift from NAP1 Majority (2008) to Novel Strain Types (2013) in One Region
Q38848131Characterization of temperate phages infecting Clostridium difficile isolates of human and animal origins.
Q60045427Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea
Q36004544Chronic kidney disease and end-stage renal disease are risk factors for poor outcomes of Clostridium difficile infection: a systematic review and meta-analysis.
Q28354123Clinical Characteristics and Treatment Outcomes of Clostridium difficile Infections by PCR Ribotype 017 and 018 Strains
Q56225357Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)
Q26778127Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027
Q37192173Clinical and Microbiologic Characteristics of Clostridium difficile Infection Caused by Binary Toxin Producing Strain in Korea
Q34263649Clinical and microbiologic characteristics of tcdA-negative variant Clostridium difficile infections
Q36402112Clinical features and characteristics of Clostridium difficile PCR-ribotype 176 infection: results from a 1-year university hospital internal ward study
Q91962993Clostridioides (Clostridium) Difficile in Food-Producing Animals, Horses and Household Pets: A Comprehensive Review
Q92228601Clostridioides difficile infection in the Asia-Pacific region
Q90648513Clostridioides difficile infections in the intensive care unit: a monocentric cohort study
Q89483643Clostridioides difficile ribotype 106: A systematic review of the antimicrobial susceptibility, genetics, and clinical outcomes of this common worldwide strain
Q91834131Clostridioides difficile ribotypes isolated from domestic environment and from patients in Bangladesh
Q52564641Clostridium difficile - From Colonization to Infection.
Q44221762Clostridium difficile 027 increasing detection in a teaching hospital in Rome, Italy
Q34520307Clostridium difficile 027 infection in Central Italy
Q34462633Clostridium difficile 027-associated pseudomembranous colitis after short-term treatment with cefuroxime and cephalexin in an elderly orthopedic patient: a case report
Q38558966Clostridium difficile Diarrhea in the Elderly: Current Issues and Management Options
Q89908699Clostridium difficile Infection: An Epidemiology Update
Q53692769Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.
Q50968625Clostridium difficile O27 colitis: hospital-onset but community-acquired.
Q35652292Clostridium difficile PCR Ribotype 018, a Successful Epidemic Genotype
Q39533078Clostridium difficile PCR ribotypes 001 and 176 - the common denominator of C. difficile infection epidemiology in the Czech Republic, 2014.
Q54239070Clostridium difficile Toxoid Vaccine Candidate Confers Broad Protection against a Range of Prevalent Circulating Strains in a Nonclinical Setting.
Q37391438Clostridium difficile associated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients with C. difficile infection
Q33728296Clostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importance
Q54298960Clostridium difficile carriage in healthy infants in the community: a potential reservoir for pathogenic strains.
Q41868062Clostridium difficile genotypes in piglet populations in Germany
Q34209440Clostridium difficile genotypes other than ribotype 078 that are prevalent among human, animal and environmental isolates
Q45354724Clostridium difficile healthcare-associated epidemics
Q38233881Clostridium difficile in Children: To Treat or Not to Treat?
Q40923400Clostridium difficile in Crete, Greece: epidemiology, microbiology and clinical disease
Q38074514Clostridium difficile in foods and animals: history and measures to reduce exposure
Q92929119Clostridium difficile in wild rodents and insectivores in the Netherlands
Q60500782Clostridium difficile infection
Q37250343Clostridium difficile infection after adult autologous stem cell transplantation: a multicenter study of epidemiology and risk factors.
Q43088433Clostridium difficile infection associated with pig farms.
Q44667578Clostridium difficile infection diagnosis in a paediatric population: comparison of methodologies
Q30605607Clostridium difficile infection in Italian urban hospitals: data from 2006 through 2011.
Q37003725Clostridium difficile infection in a French university hospital: Eight years of prospective surveillance study
Q42242661Clostridium difficile infection in hospitalized patients at university clinical center tuzla, bosnia and herzegovina: a 4 year experience
Q37870297Clostridium difficile infection in humans and animals, differences and similarities
Q38105281Clostridium difficile infection in patients with HIV/AIDS.
Q38600142Clostridium difficile infection in patients with liver disease: a review
Q38268703Clostridium difficile infection in the postcolectomy patient
Q37879185Clostridium difficile infection: a comprehensive review
Q30316981Clostridium difficile infection: guideline-based diagnosis and treatment
Q38757841Clostridium difficile infections in Finland, 2008-2015: trends, diagnostics and ribotypes
Q30244040Clostridium difficile infections in geriatric patients
Q64951652Clostridium difficile ribotype 017 - characterization, evolution and epidemiology of the dominant strain in Asia.
Q37026536Clostridium difficile ribotype diversity at six health care institutions in the United States
Q35952584Clostridium difficile ribotypes in Austria: a multicenter, hospital-based survey
Q36450352Clostridium difficile ribotypes in humans and animals in Brazil
Q38154925Clostridium difficile surveillance: harnessing new technologies to control transmission
Q64240941Clostridium difficile-associated Diarrhea in Developing Countries: A Systematic Review and Meta-Analysis
Q40065547Clostridium difficile-associated deaths from 2013-2016 in Munich and Nuremberg : Reporting behavior and patient characteristics
Q36134269Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus
Q38017389Clostridium difficile: development of a novel candidate vaccine
Q34162219Clostridium: transmission difficile?
Q52622824Coinfection with 2 Clostridium difficile ribotypes in China: A case report.
Q37288133Community- and Healthcare-Associated Clostridium difficile Infections, Finland, 2008-2013(1).
Q92028651Community-Onset Clostridioides Difficile Infection in Hospitalized Patients in The Netherlands
Q37655456Community-acquired Clostridium difficile infection: an increasing public health threat
Q89736759Comparative Study of Clostridium difficile Clinical Detection Methods in Patients with Diarrhoea
Q40790084Complications of Hospital-Onset Healthcare Facility-Associated Clostridium difficile Infections Among Veterans
Q38192010Control of Clostridium difficile infection in the hospital setting
Q38538221Controversies Around Epidemiology, Diagnosis and Treatment of Clostridium difficile Infection
Q30235278Conventional and alternative treatment approaches for Clostridium difficile infection
Q41868020Correlation between Clostridium difficile bacterial load, commercial real-time PCR cycle thresholds, and results of diagnostic tests based on enzyme immunoassay and cell culture cytotoxicity assay.
Q36113668Cost of hospital management of Clostridium difficile infection in United States-a meta-analysis and modelling study
Q64062094Cost savings following faecal microbiota transplantation for recurrent infection
Q36280168Cost-effectiveness in Clostridium difficile treatment decision-making
Q36757254Cross-sectional study reveals high prevalence of Clostridium difficile non-PCR ribotype 078 strains in Australian veal calves at slaughter
Q34285444Current status of Clostridium difficile infection epidemiology
Q41655280DNA microarray-based PCR ribotyping of Clostridium difficile
Q34707553Depression, antidepressant medications, and risk of Clostridium difficile infection
Q38687899Description and validation of a new automated surveillance system for Clostridium difficile in Denmark
Q90732886Design and Expression of Specific Hybrid Lantibiotics Active Against Pathogenic Clostridium spp
Q35095564Development and validation of an internationally-standardized, high-resolution capillary gel-based electrophoresis PCR-ribotyping protocol for Clostridium difficile
Q41650253Diagnosis of Clostridium difficile: real-time PCR detection of toxin genes in faecal samples is more sensitive compared to toxigenic culture.
Q26777157Diagnostic accuracy of loop-mediated isothermal amplification in detection of Clostridium difficile in stool samples: a meta-analysis
Q40130826Diagnostic workup and therapy of infectious diarrhea. Current standards
Q37293591Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection
Q41631010Different antibiotic resistance and sporulation properties within multiclonal Clostridium difficile PCR ribotypes 078, 126, and 033 in a single calf farm.
Q54548493Difficile indeed.
Q26741585Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Various Multiresistant Bacteria
Q28084700Diversity and Evolution in the Genome of Clostridium difficile
Q50042760Diversity and antimicrobial activity of Pseudovibrio spp. from Irish marine sponges
Q40595939Diversity of Clostridium difficile PCR ribotypes in Europe: results from the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID), 2012 and 2013.
Q40554081Draft Genome Sequence of Clostridium difficile Belonging to Ribotype 018 and Sequence Type 17
Q40604220Draft Genome Sequence of Clostridium difficile Strain IT1118, an Epidemic Isolate Belonging to the Emerging PCR Ribotype 018.
Q40784614Economic burden of Clostridium difficile associated diarrhoea: a cost-of-illness study from a German tertiary care hospital.
Q36307202Economic burden of Clostridium difficile in five hospitals of the Florence health care system in Italy
Q97426271Economic evaluation of Faecal microbiota transplantation compared to antibiotics for the treatment of recurrent Clostridioides difficile infection
Q48319188Editorial commentary: Changing epidemiology of Clostridium difficile and emergence of new virulent strains
Q40459481Effect of a national 4C antibiotic stewardship intervention on the clinical and molecular epidemiology of Clostridium difficile infections in a region of Scotland: a non-linear time-series analysis.
Q89884739Effect of sub-MIC values of metronidazole, ciprofloxacin, and imipenem on the growth and toxin production in Clostridioides difficile
Q89514920Effectiveness and cost-effectiveness of a Clostridium difficile vaccine candidate in a hospital setting
Q89984713Effects of co-infection on the clinical outcomes of Clostridium difficile infection
Q33831557Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study
Q41158827Efficacy of alternative fidaxomicin dosing regimens for treatment of simulated Clostridium difficile infection in an in vitro human gut model
Q50041908Efficacy of an Optimised Bacteriophage Cocktail to Clear Clostridium difficile in a Batch Fermentation Model
Q36708973Emergence and global spread of epidemic healthcare-associated Clostridium difficile
Q41195681Emergence and spread of predominantly community-onset Clostridium difficile PCR ribotype 244 infection in Australia, 2010 to 2012.
Q36997707Emergence of Clostridium difficile infection in tuberculosis patients due to a highly rifampicin-resistant PCR ribotype 046 clone in Poland
Q93016993Eosinopenia and Binary Toxin Increase Mortality in Hospitalized Patients With Clostridioides difficile Infection
Q36055810Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach
Q31138398Epidemiology and Recurrence Rates of Clostridium difficile Infections in Germany: A Secondary Data Analysis
Q28073805Epidemiology and Risk Factors for Community-Associated Clostridium difficile Infection: A Narrative Review
Q36186012Epidemiology and outcome of Clostridium difficile infections in patients hospitalized in Internal Medicine: findings from the nationwide FADOI-PRACTICE study
Q34027474Epidemiology of Clostridium difficile infection
Q36826679Epidemiology of Clostridium difficile infection and risk factors for unfavorable clinical outcomes: results of a hospital-based study in Barcelona, Spain
Q37033281Epidemiology of Clostridium difficile infection in Asia
Q41684190Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study
Q41095363Epidemiology of Clostridium difficile infection: results of a hospital-based study in Krakow, Poland
Q44041662Epidemiology of Clostridium difficile on a veal farm: prevalence, molecular characterization and tetracycline resistance
Q58376524Epidemiology of Clostridium difficile-associated disease in internal medicine wards in northern Italy
Q38068605Epidemiology, diagnosis and treatment of Clostridium difficile infection
Q49638608Equivalent Performance of the Cobas® Cdiff Test for Use on the Cobas® Liat® System and the Cobas® 4800 System
Q36465447Evaluation of Xpert C. difficile, BD MAX Cdiff, IMDx C. difficile for Abbott m2000, and Illumigene C. difficile Assays for Direct Detection of Toxigenic Clostridium difficile in Stool Specimens
Q43817719Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
Q51353976Evaluation of three enzyme immunoassays and a loop-mediated isothermal amplification test for the laboratory diagnosis of Clostridium difficile infection.
Q64109739Evolutionary and Genomic Insights into Sequence Type 11: a Diverse Zoonotic and Antimicrobial-Resistant Lineage of Global One Health Importance
Q34391822Evolutionary history of the Clostridium difficile pathogenicity locus
Q35964926Excess Mortality Attributable to Clostridium difficile and Risk Factors for Infection in an Historic Cohort of Hospitalised Patients Followed Up in the United Kingdom Death Register
Q35172641Exposure of neutralizing epitopes in the carboxyl-terminal domain of TcdB is altered by a proximal hypervariable region.
Q35273341Extended multilocus variable-number tandem-repeat analysis of Clostridium difficile correlates exactly with ribotyping and enables identification of hospital transmission
Q49610079Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial
Q36311457Factors Associated With Complications of Clostridium difficile Infection in a Multicenter Prospective Cohort
Q54417278Faecal microbiota transplantation and bacteriotherapy for recurrent Clostridium difficile infection: a retrospective evaluation of 31 patients.
Q47632083Fecal calprotectin in management of Clostridium difficile infection: a longitudinal study.
Q36379088Fecal microbiota transplantation in relapsing Clostridium difficile infection
Q26765214Fecal microbiota transplantation: in perspective
Q36647979Fecal transplant in refractory Clostridium difficile colitis
Q61713430Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial
Q34798381First Polish outbreak of Clostridium difficile ribotype 027 infections among dialysis patients
Q91770291Five-year Pan-European, longitudinal surveillance of Clostridium difficile ribotype prevalence and antimicrobial resistance: the extended ClosER study
Q92218161From Root to Tips: Sporulation Evolution and Specialization in Bacillus subtilis and the Intestinal Pathogen Clostridioides difficile
Q99558111GABAergic but not Antidepressant Medications Increase Risk for Clostridioides difficile Infection in a National Cohort of Veterans
Q41690945Genetic relatedness between Japanese and European isolates of Clostridium difficile originating from piglets and their risk associated with human health
Q37578190Genome Analysis of Clostridium difficile PCR Ribotype 014 Lineage in Australian Pigs and Humans Reveals a Diverse Genetic Repertoire and Signatures of Long-Range Interspecies Transmission
Q93221196Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile
Q36635701Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence
Q91692777Genomic Delineation of Zoonotic Origins of Clostridium difficile
Q36123790Growth Patterns of Clostridium difficile - Correlations with Strains, Binary Toxin and Disease Severity: A Prospective Cohort Study.
Q98465499High Prevalence of Genetically Related Clostridium Difficile Strains at a Single Hemato-Oncology Ward Over 10 Years
Q92573412High frequency of toxigenic Clostridium difficile and Clostridium perfringens coinfection among diarrheic patients at health care facility-onset (HCFO) and community-onset (CO) centers in Bogotá, Colombia
Q34131173High prevalence of Clostridium difficile colonization among nursing home residents in Hesse, Germany
Q43711757Hospital Clostridium difficile infection testing rates: is "don't ask, don't tell" at play?
Q89908729Hospital Infection Control: Clostridioides difficile
Q38603025Hospital-acquired Clostridium difficile infection in Mainland China: A seven-year (2009-2016) retrospective study in a large university hospital
Q40357181Hospital-based Clostridium difficile infection surveillance reveals high proportions of PCR ribotypes 027 and 176 in different areas of Poland, 2011 to 2013.
Q38969987Host response to Clostridium difficile infection: Diagnostics and detection
Q41131155How do Clostridium difficile infections affect nurses' everyday hospital work: A qualitative study
Q38141579Hype or hypervirulence: a reflection on problematic C. difficile strains.
Q64232660Hypoalbuminemia as predictor of recurrence of Clostridium difficile infection
Q34456650ICU-Onset Clostridium difficile infection in a university hospital in China: a prospective cohort study
Q33693904Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses
Q92306236Impact of a training program on the surveillance of Clostridioides difficile infection
Q41294771Impact of clinical awareness and diagnostic tests on the underdiagnosis of Clostridium difficile infection
Q38716945Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life
Q51317741Impact of the type of diagnostic assay on Clostridium difficile infection and complication rates in a mandatory reporting program.
Q41148829In vitro susceptibility of Clostridium difficile to SMT19969 and comparators, as well as the killing kinetics and post-antibiotic effects of SMT19969 and comparators against C. difficile
Q36658426Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication
Q42605505Increased hospital length of stay attributable to Clostridium difficile infection in patients with four co-morbidities: an analysis of hospital episode statistics in four European countries
Q39755382Increasing incidence of Clostridium difficile infections: results from a 5-year retrospective study in a large teaching hospital in the Italian region with the oldest population.
Q38691798Increasing incidence of Clostridium difficile ribotype 001 associated with severe course of the infection and previous fluoroquinolone use in the Czech Republic, 2015.
Q64120376Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing
Q40182314Individualized treatment strategies for Clostridium difficile infections
Q41007833Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis
Q90324385Inpatient Expenditures Attributable to Hospital-Onset Clostridium difficile Infection: A Nationwide Case-Control Study in Japan
Q33909227International Clostridium difficile animal strain collection and large diversity of animal associated strains
Q51581458Intestinal Epithelial Cell Response to Clostridium difficile Flagella.
Q60301191Intrinsic Class D β-Lactamases of
Q38638507Is there a relationship between the presence of the binary toxin genes in Clostridium difficile strains and the severity of C. difficile infection (CDI)?
Q31105341Isolation of C. difficile Carriers Alone and as Part of a Bundle Approach for the Prevention of Clostridium difficile Infection (CDI): A Mathematical Model Based on Clinical Study Data
Q35035950Laboratory detection of Clostridium difficile in piglets in Australia
Q34429629Long-Term Clinical Outcome of Clostridium difficile Infection in Hospitalized Patients: A Single Center Study
Q37287137Longitudinal Investigation of Carriage Rates, Counts, and Genotypes of Toxigenic Clostridium difficile in Early Infancy.
Q36208584Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole
Q41251501Low Prevalence of Clostridium difficile in Slaughter Pigs in Korea.
Q34187096Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations
Q35896384Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model
Q55311464Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections.
Q92392559Method comparison for the direct enumeration of bacterial species using a chemostat model of the human colon
Q52801676Microbial Preparations (Probiotics) for the Prevention of Clostridium difficile Infection in Adults and Children: An Individual Patient Data Meta-analysis of 6,851 Participants.
Q34284603Mini-review: Epidemiology and zoonotic potential of multiresistant bacteria and Clostridium difficile in livestock and food
Q34786520Modelling the transmission of healthcare associated infections: a systematic review
Q54211969Molecular Characterization of Clostridium difficile Isolates in China From 2010 to 2015.
Q39038610Molecular Epidemiology of Clostridium difficile Infection in Hospitalized Patients in Eastern China
Q40935046Molecular characterization and antimicrobial susceptibility of Clostridium difficile isolated from rabbits raised for meat production.
Q41620586Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolated from a university teaching hospital in Japan
Q36326824Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolates from two Korean hospitals
Q55100322Molecular epidemiology of Clostridium difficile in two tertiary care hospitals in Shandong Province, China.
Q37264255Molecular epidemiology of Clostridium difficile infection in a major chinese hospital: an underrecognized problem in Asia?
Q90489435Molecular epidemiology of Clostridium difficile isolated from piglets
Q86070124Molecular epidemiology of Clostridium difficile strains from nosocomial-acquired infections
Q38142247Molecular methods in the diagnosis of Clostridium difficile infections: an update
Q40279012Molecular typing and antimicrobial susceptibility testing to six antimicrobials of Clostridium difficile isolates from three Czech hospitals in Eastern Bohemia in 2011-2012.
Q39727030Multidrug resistance in European Clostridium difficile clinical isolates
Q46012656Multilocus sequence typing (MLST) analysis of 104 Clostridium difficile strains isolated from China.
Q35599031Multiplex PCR method for detection of Clostridium difficile tcdA, tcdB, cdtA, and cdtB and internal in-frame deletion of tcdC
Q26859965Murine models to study Clostridium difficile infection and transmission
Q58777719National Surveillance for Clostridioides difficile Infection, Sweden, 2009-2016
Q41696807Nationwide surveillance study of Clostridium difficile in Australian neonatal pigs shows high prevalence and heterogeneity of PCR ribotypes
Q35098190New role for human α-defensin 5 in the fight against hypervirulent Clostridium difficile strains
Q55405974Novel Antimicrobials for the Treatment of Clostridium difficile Infection.
Q36060123Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model
Q37588571Nutrition economic evaluation of a probiotic in the prevention of antibiotic-associated diarrhea
Q41392923Occurrence of zoonotic clostridia and Yersinia in healthy cattle.
Q38583798Optimising gut colonisation resistance against Clostridium difficile infection.
Q48312394Oral teicoplanin versus oral vancomycin for the treatment of severe Clostridium difficile infection: a prospective observational study
Q31158719Outbreak of Clostridium difficile PCR ribotype 027--the recent experience of a regional hospital.
Q57568952Outcome ofClostridium difficile-associated disease in solid organ transplant recipients: a prospective and multicentre cohort study
Q89618938PCR ribotypes of Clostridioides difficile across Texas from 2011 to 2018 including emergence of ribotype 255
Q30452301Pathogenic C difficile is here (and everywhere) to stay
Q38176852Patients' experience and perception of hospital-treated Clostridium difficile infections: a qualitative study
Q89794975Perception of quality of life in people experiencing or having experienced a Clostridioides difficile infection: a US population survey
Q92023289Phosphorylation and functionality of CdtR in Clostridium difficile
Q104495284Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes
Q89454312Plasmid-mediated metronidazole resistance in Clostridioides difficile
Q40091474Point-prevalence survey of healthcare facility-onset healthcare-associated Clostridium difficile infection in Greek hospitals outside the intensive care unit: The C. DEFINE study.
Q34670270Polymerase chain reaction ribotyping of Clostridium difficile isolates in Qatar: a hospital-based study
Q33827614Poorer outcomes among cancer patients diagnosed with Clostridium difficile infections in United States community hospitals
Q51525731Portrait Toxigenic Clostridium difficile assay, an isothermal amplification assay detects toxigenic C. difficile in clinical stool specimens.
Q35711361Predictors and outcomes of readmission for Clostridium difficile in a national sample of medicare beneficiaries
Q40941975Predominance of Clostridium difficile ribotypes 012, 027 and 046 in a university hospital in Chile, 2012.
Q47144217Preliminary screening of type IV secretion system in divergent geographic sources of Clostridium difficile
Q40404657Presence of Clostridium difficile in pig faecal samples and wild animal species associated with pig farms.
Q58797243Prevalence and Strain Characterization of in Representative Regions of Germany, Ghana, Tanzania and Indonesia - A Comparative Multi-Center Cross-Sectional Study
Q56768549Prevalence and genotypic characterization of Clostridium difficile from ruminants in Switzerland
Q34210895Prevalence and molecular characterization of Clostridium difficile isolated from feedlot beef cattle upon arrival and mid-feeding period
Q40359443Prevalence and molecular epidemiology of Clostridium difficile infection in Thailand.
Q35112200Prevalence and pathogenicity of binary toxin-positive Clostridium difficile strains that do not produce toxins A and B
Q34048138Prevalence and risk factors for asymptomatic Clostridium difficile carriage
Q57193557Prevalence of Clostridium Difficile-Associated Diarrhoea in Hospitalised Patients (Results of a Russian Prospective Multicentre Study)
Q91447897Prevalence of Clostridium difficile and Clostridium perfringens in Swiss horses with and without gastrointestinal disease and microbiota composition in relation to Clostridium difficile shedding
Q57660817Prevalence of Colonization and Infection with Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus and of Clostridium difficile Infection in Canadian Hospitals
Q34817165Prevalence of gastrointestinal Clostridium difficile carriage in Australian sheep and lambs
Q38303539Probiotics for antibiotic-associated diarrhea: do we have a verdict?
Q35867366Prospective observational study comparing three different treatment regimes in patients with Clostridium difficile infection
Q26828910Quality of care delivered to hospitalized inflammatory bowel disease patients
Q28258066Randomised clinical trial: faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent Clostridium difficile infection
Q26767079Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection
Q37671489Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response
Q34182686Recombination drives evolution of the Clostridium difficile 16S-23S rRNA intergenic spacer region
Q36547354Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing
Q40144431Recreational sandboxes for children and dogs can be a source of epidemic ribotypes of Clostridium difficile.
Q35685694Recurrent Clostridium difficile infection and the microbiome.
Q35822541Recurrent Clostridium difficile infection: From colonization to cure
Q37875055Recurrent Clostridium difficile infection: what are the treatment options?
Q41127419Regional differences in Clostridium difficile infections in relation to fluoroquinolone and proton pump inhibitor use, Finland, 2008-2011.
Q36811255Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection
Q41110387Ribotyping of Clostridium difficile strains associated with nosocomial transmission and relapses in a Swedish County
Q26747248Ridinilazole: a novel therapy for Clostridium difficile infection
Q40631036Risk Factors for Clostridium Difficile Diarrhea in Patients With Solid Organ Transplantation.
Q50054448Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study
Q41739117Risk factors and management of refractory or recurrent clostridium difficile infection in ileal pouch patients
Q37724361Risk factors for Clostridium difficile infection in surgical patients hospitalized in a tertiary hospital in Belgrade, Serbia: a case-control study
Q83731997Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case-control study
Q27021390Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review
Q38334364Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis
Q35866318Risk factors for recurrent hospital-acquired Clostridium difficile infection in a Japanese university hospital
Q39372386Risk factors for short- and long-term mortality in very old patients with Clostridium difficile infection: A retrospective study
Q47632421Safety and immunogenicity of Clostridium difficile toxoid vaccine in Japanese adults
Q35689261Seasonal variations in Clostridium difficile infections are associated with influenza and respiratory syncytial virus activity independently of antibiotic prescriptions: a time series analysis in Quebec, Canada
Q36238732Seasonality of Clostridium difficile infections in Southern Germany
Q37518712Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation
Q35035736Sequence variation in tcdA and tcdB of Clostridium difficile: ST37 with truncated tcdA is a potential epidemic strain in China
Q35043878Spo0A differentially regulates toxin production in evolutionarily diverse strains of Clostridium difficile
Q33798369Strain types and antimicrobial resistance patterns of Clostridium difficile isolates from the United States, 2011 to 2013
Q34419009Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 Update
Q85920456Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 update
Q38767322Subtyping and antimicrobial susceptibility of Clostridium difficile PCR ribotype 078/126 isolates of human and animal origin.
Q52323510Subtyping of Clostridium difficile PCR ribotypes 591, 106 and 002, the dominant strain types circulating in Medellin, Colombia.
Q55085307Successful Fecal Microbiota Transplantation in a Patient with Severe Complicated Clostridium difficile Infection after Liver Transplantation.
Q34447678Succession in the gut microbiome following antibiotic and antibody therapies for Clostridium difficile
Q24618413Surgical Management of Clostridium difficile Colitis
Q40683812Surveillance for antimicrobial resistance in Australian isolates of Clostridium difficile, 2013-14.
Q37628792Surveillance of Clostridium difficile Infections: Results from a Six-Year Retrospective Study in Nine Hospitals of a North Italian Local Health Authority
Q47103184Surveillance of antibiotic resistance among common Clostridium difficile ribotypes in Hong Kong
Q39548845Survey of Clostridium difficile infection surveillance systems in Europe, 2011.
Q40596125Survey of diagnostic and typing capacity for Clostridium difficile infection in Europe, 2011 and 2014.
Q34468946Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
Q34389455TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm
Q55471972The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains.
Q41817325The Clostridium difficile spo0A gene is a persistence and transmission factor
Q54265880The Epidemiology of Community Clostridium difficile Infection: A Five-Year Population-Based Study on the Bailiwick of Jersey, Channel Islands.
Q89908707The Inflammasome and Type-2 Immunity in Clostridium difficile Infection
Q38489324The Risks of Incident and Recurrent Clostridium difficile-Associated Diarrhea in Chronic Kidney Disease and End-Stage Kidney Disease Patients: A Systematic Review and Meta-Analysis.
Q30276036The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
Q30318298The changing burden of infectious disease in Europe
Q28830191The complexity and diversity of the Pathogenicity Locus in Clostridium difficile clade 5
Q38036704The continually evolving Clostridium difficile species
Q53735645The effect of hospital biocide sodium dichloroisocyanurate on the viability and properties of Clostridium difficile spores.
Q41225310The emergence of Clostridium difficile PCR-ribotype 001 in Slovakia
Q33626443The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact
Q38744998The epidemiology of Clostridium difficile infection in a national kidney transplant center.
Q40205951The evolution of urban C. difficile infection (CDI): CDI in 2009-2011 is less severe and has better outcomes than CDI in 2006-2008.
Q64102862The first isolation of Clostridium difficile RT078/ST11 from pigs in China
Q40224335The incidence and clinical symptomatology of Clostridium difficile infections in a community setting in a cohort of Danish patients attending general practice
Q42211155The prediction of complicated Clostridium difficile infections in children.
Q39302972The projected effectiveness of Clostridium difficile vaccination as part of an integrated infection control strategy
Q90125013The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics
Q43684182The relation between farm specific factors and prevalence of Clostridium difficile in slaughter pigs.
Q47922235The roles of Clostridium difficile and norovirus among gastroenteritis-associated deaths in the United States, 1999-2007.
Q52809285The zoonotic potential of Clostridium difficile from small companion animals and their owners.
Q55103812Thirty-Day Readmissions in Hospitalized Patients Who Received Bezlotoxumab With Antibacterial Drug Treatment for Clostridium difficile Infection.
Q34338268Toxigenic Clostridium difficile PCR ribotypes from wastewater treatment plants in southern Switzerland
Q38815414Toxin A-negative toxin B-positive ribotype 017 Clostridium difficile is the dominant strain type in patients with diarrhoea attending tuberculosis hospitals in Cape Town, South Africa
Q37546536Toxin-producing Clostridium difficile strains as long-term gut colonizers in healthy infants
Q92906241Two-year analysis of Clostridium difficile ribotypes associated with increased severity
Q41629539Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID).
Q42144252Using a dog's superior olfactory sensitivity to identify Clostridium difficile in stools and patients: proof of principle study
Q36277090Utilizing rapid multiple-locus variable-number tandem-repeat analysis typing to aid control of hospital-acquired Clostridium difficile Infection: a multicenter study
Q38196682Vaccines against Clostridium difficile
Q48300202Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials
Q37475243Variability in testing policies and impact on reported Clostridium difficile infection rates: results from the pilot Longitudinal European Clostridium difficile Infection Diagnosis surveillance study (LuCID)
Q90087903Virulence of new variant strains of Clostridium difficile producing only toxin A or binary toxin in the hamster model
Q26795429WSES guidelines for management of Clostridium difficile infection in surgical patients
Q91906110Whole genome analysis reveals new insights into the molecular characteristics of Clostridioides difficile NAP1/BI/027/ST1 clinical isolates in the People's Republic of China
Q37681661Whole genome sequences of three Clade 3 Clostridium difficile strains carrying binary toxin genes in China
Q35898112Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.
Q64066379Whole-genome sequencing reveals nosocomial Clostridioides difficile transmission and a previously unsuspected epidemic scenario
Q53715705Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans.
Q30575525[Current data and trends on the development of antibiotic resistance of Clostridium difficile].