Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors

scholarly article by Peixin Dong et al published 2018 in Frontiers in Genetics

Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FGENE.2018.00471
P932PMC publication ID6196292
P698PubMed publication ID30374364

P50authorYukiharu TodoQ87214075
Hidemichi WatariQ88405179
Noriko KobayashiQ90163395
Sharon J B HanleyQ96193946
Junming YueQ114435116
Peixin DongQ30505631
P2093author name stringYing Xiong
P2860cites workLncRNA NEAT1 enhances the radio-resistance of cervical cancer via miR-193b-3p/CCND1 axisQ49996731
Nuclear paraspeckle assembly transcript 1 promotes the metastasis and epithelial-mesenchymal transition of hepatoblastoma cells by inhibiting miR-129-5pQ50119880
Evidence for natural antisense transcript-mediated inhibition of microRNA functionQ21184035
Visualizing the secondary and tertiary architectural domains of lncRNA RepA.Q50463042
Regulation of NEAT1/miR-214-3p on the growth, migration and invasion of endometrial carcinoma cells.Q50697454
LncRNA, NEAT1 is a prognosis biomarker and regulates cancer progression via epithelial-mesenchymal transition in clear cell renal cell carcinoma.Q50856966
Recurrent and functional regulatory mutations in breast cancer.Q50918699
Long non-coding RNA NEAT1 promotes hepatocellular carcinoma cell proliferation through the regulation of miR-129-5p-VCP-IκB.Q50991345
lncRNA NEAT1 is closely related with progression of breast cancer via promoting proliferation and EMT.Q51088427
NEAT1_2 functions as a competing endogenous RNA to regulate ATAD2 expression by sponging microRNA-106b-5p in papillary thyroid cancer.Q52668584
lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR‑365/RGS20 in oral squamous cell carcinoma.Q52684015
Knockdown of the oncogene LncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma.Q52719522
LncRNA NEAT1 Impacts Cell Proliferation and Apoptosis of Colorectal Cancer via Regulation of Akt Signaling.Q52936441
The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer.Q53732400
Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation.Q55035224
Cancer stem cells as key drivers of tumour progression.Q55122201
LncRNA NEAT1/let-7a-5p axis regulates the cisplatin resistance in nasopharyngeal carcinoma by targeting Rsf-1 and modulating the Ras-MAPK pathwayQ88131382
Clinical significance of up-regulated lncRNA NEAT1 in prognosis of ovarian cancerQ95526080
Long Noncoding RNA NEAT1 Promotes Growth and Metastasis of Cholangiocarcinoma CellsQ95802781
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The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor PhosphorylationQ24297656
A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNAQ24630341
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIPQ24630900
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor geneQ24632383
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Long non-coding RNAs as novel targets for therapy in hepatocellular carcinomaQ26751346
Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer DiagnosticsQ26753032
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Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancersQ33741775
Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexesQ33741883
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancerQ34091442
Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cellsQ34270770
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.Q34332428
Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypesQ34654714
PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrityQ34919601
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.Q35602321
Linking Long Noncoding RNA Localization and FunctionQ38921242
Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.Q38998624
Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targetsQ39031286
The long non-coding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2.Q39052105
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.Q39584699
The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various Cancers: A Meta-analysis Based on the GEO Database and LiteratureQ39676060
Upregulation and clinicopathological significance of long non-coding NEAT1 RNA in NSCLC tissuesQ41100351
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancerQ41830068
The long non-coding RNA NEAT1 enhances epithelial-to-mesenchymal transition and chemoresistance via the miR-34a/c-Met axis in renal cell carcinomaQ42252911
Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanismQ42378413
Knockdown of Long Non-Coding RNA NEAT1 Inhibits Proliferation and Invasion and Induces Apoptosis of Osteosarcoma by Inhibiting miR-194 ExpressionQ42647018
RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.Q42709502
The long noncoding RNA Neat1 is required for mammary gland development and lactation.Q43015249
NEAT1 regulates cell proliferation and apoptosis of ovarian cancer by miR-34a-5p/BCL2.Q47135519
LncRNA NEAT1 contributes to paclitaxel resistance of ovarian cancer cells by regulating ZEB1 expression via miR-194.Q47163226
Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-κB pathwayQ47168973
Long noncoding RNA NEAT1 regulate papillary thyroid cancer progression by modulating miR-129-5p /KLK7 expressionQ47214574
Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian CancerQ47360627
Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2.Q47595578
Long non-coding RNA NEAT1 overexpression is associated with unfavorable prognosis in patients with hepatocellular carcinoma after hepatectomy: A Chinese population-based studyQ47690409
NEAT1 negatively regulates miR-218 expression and promotes breast cancer progressionQ47762876
Expression and role of long non-coding RNA H19 in carcinogenesisQ47767703
The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancerQ47956744
HIF-2α activated lncRNA NEAT1 promotes hepatocellular carcinoma cell invasion and metastasis by affecting the epithelial-mesenchymal transitionQ48089437
LncRNA NEAT1 promotes dexamethasone resistance in multiple myeloma by targeting miR-193a/MCL1 pathway.Q48178696
NEAT1 acts as an inducer of cancer stem cell-like phenotypes in NSCLC by inhibiting EGCG-upregulated CTR1.Q48274541
NEAT1 promotes cell proliferation and invasion in hepatocellular carcinoma by negative regulating miR-613 expressionQ48701391
Therapeutic Targeting of Long Non-Coding RNAs in CancerQ49961986
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Up regulation of the long non-coding RNA NEAT1 promotes esophageal squamous cell carcinoma cell progression and correlates with poor prognosisQ36250659
Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancerQ36267118
NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancerQ36413858
LincRNA-p21 suppresses target mRNA translationQ36431717
Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathwayQ36517652
Enhanced expression of long non-coding RNA NEAT1 is associated with the progression of gastric adenocarcinomasQ36612014
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.Q36649171
Long Noncoding RNAs in Cancer PathwaysQ36796798
HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancerQ37094937
Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequencesQ37325540
Paraspeckles: nuclear bodies built on long noncoding RNAQ37342470
Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.Q37355325
Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway.Q37588369
Discovery of Cancer Driver Long Noncoding RNAs across 1112 Tumour Genomes: New Candidates and Distinguishing FeaturesQ37609524
Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNA let-7eQ37641753
Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesisQ37662194
LncRNAs act as prognostic and diagnostic biomarkers in renal cell carcinoma: a systematic review and meta-analysisQ37687564
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axisQ37706651
Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancerQ37718438
Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer TherapyQ37723274
Structure and function of long noncoding RNAs in epigenetic regulationQ38086776
The cross talk between long, non-coding RNAs and microRNAs in gastric cancerQ38654296
Long non-coding RNA NEAT1 acts as oncogene in NSCLC by regulating the Wnt signaling pathwayQ38714726
Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214.Q38725077
Long non-coding RNA NEAT1 facilitates pancreatic cancer progression through negative modulation of miR-506-3pQ38728921
Silencing of the long non-coding RNA NEAT1 suppresses glioma stem-like properties through modulation of the miR-107/CDK6 pathwayQ38729439
The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinomaQ38737174
Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinomaQ38743991
The Non-Coding Transcriptome of Prostate Cancer: Implications for Clinical Practice.Q38744451
Long noncoding RNA NEAT1 is an unfavorable prognostic factor and regulates migration and invasion in gastric cancerQ38776920
HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-MycQ38807572
Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axisQ38846361
EMT: 2016.Q38883448
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmolecular medicineQ3523816
P304page(s)471
P577publication date2018-01-01
P1433published inFrontiers in GeneticsQ2499875
P1476titleLong Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors
P478volume9

Reverse relations

cites work (P2860)
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Q98288371The role of NEAT1 lncRNA in squamous cell carcinoma of the head and neck is still difficult to define
Q91789083lncRNA NEAT1 Facilitates Cell Proliferation, Invasion and Migration by Regulating CBX7 and RTCB in Breast Cancer

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