Biochemical identification of a direct physical interaction between the CD4: p56lck and Ti(TcR)/CD3 complexes

scientific article published on 01 July 1991

Biochemical identification of a direct physical interaction between the CD4: p56lck and Ti(TcR)/CD3 complexes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.1830210712
P698PubMed publication ID1829412

P50authorBrian DrukerQ373427
P2093author name stringAnderson P
Schlossman SF
Burgess KE
Rudd CE
Odysseos AD
Zalvan C
P2860cites workThe CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complexQ24293680
Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation siteQ24321802
Interaction between CD4 and class II MHC molecules mediates cell adhesionQ24339626
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytesQ24653345
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusQ28259668
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lckQ28506433
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVQ28646817
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptorQ33620349
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifsQ34149224
T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligationQ34317330
Perturbation of the T4 molecule transmits a negative signal to T cellsQ36350963
Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinaseQ36707725
Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytesQ36762437
CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptorQ37565794
A signaling role for the cytoplasmic segment of the CD8 alpha chain detected under limiting stimulatory conditions.Q37723387
Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activationQ38262262
The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domainQ38343044
T Cell Subsets and the Recognition of MHC ClassQ40115713
The differentiation and function of human T lymphocytesQ40284222
The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 productQ41764902
Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.Q44368136
Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cellsQ46508660
No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120Q46800989
Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA.Q48358299
Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertionQ48368270
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.Q48373044
High resolution two-dimensional electrophoresis of basic as well as acidic proteinsQ58492650
Evidence for a physical association of CD4 and the CD3: α : β T-cell receptorQ58974599
Structural nature of the interaction between T lymphocyte surface molecule CD4 and the intracellular protein tyrosine kinase lckQ67275646
Identification of the human T-lymphocyte protein-tyrosine kinase by peptide-specific antibodiesQ68808682
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptorQ68973514
Most anti-human CD3 monoclonal antibodies are directed to the CD3 epsilon subunitQ69078645
Effective activation of resting mouse T lymphocytes by cross-linking submitogenic concentrations of the T cell antigen receptor with either Lyt-2 or L3T4Q70341114
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)1663-1668
P577publication date1991-07-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleBiochemical identification of a direct physical interaction between the CD4:p56lck and Ti(TcR)/CD3 complexes
P478volume21