Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

scientific article published on 09 December 2014

Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JPI.12197
P698PubMed publication ID25424643

P50authorStefan TukajQ57457199
Konrad KleszczyńskiQ83169691
P2093author name stringDetlef Zillikens
Ronald Wolf
Tobias W Fischer
Michael Kasperkiewicz
Stephanie Zwicker
P2860cites workPineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*Q22306227
Functional activity of serotoninergic and melatoninergic systems expressed in the skinQ28206451
Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B lightQ28279176
Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitinationQ28505337
UV damage, DNA repair and skin carcinogenesisQ29394071
HaCaT Cell Proliferation Influenced by MelatoninQ33193660
Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70.Q33648551
Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrityQ33713394
Photoaging of human skinQ34115589
Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine systemQ34294075
Key role of CRF in the skin stress response systemQ34363640
Heat shock proteins in the photobiology of human skinQ34421860
Heat shock proteins and the skinQ34693063
Keratinocytes and cytokinesQ34712580
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.Q35126481
Melatonin membrane receptors in peripheral tissues: distribution and functionsQ35784330
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun.Q36022682
Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytesQ36627315
Hsp70 chaperone as a survival factor in cell pathologyQ36674471
Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.Q36945150
Melatonin in the skin: synthesis, metabolism and functionsQ37044158
Mechanisms of mutation formation with long-wave ultraviolet light (UVA).Q37059181
Melatonin as a major skin protectant: from free radical scavenging to DNA damage repairQ37222696
The role of heat shock proteins in gastrointestinal diseasesQ37516972
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK.Q38045452
Extracellular Hsp70: export and functionQ38201539
Melatonin: a well-documented antioxidant with conditional pro-oxidant actionsQ38233680
Heat shock proteins in the skinQ40090250
Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systemsQ40263679
Short- and long-wave UV light (UVB and UVA) induce similar mutations in human skin cellsQ40336768
Melatonin reduces UV-induced reactive oxygen species in a dose-dependent manner in IL-3-stimulated leukocytesQ43695260
DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way.Q44107650
Melatonin suppresses reactive oxygen species induced by UV irradiation in leukocytesQ45009952
Development of a short-term human full-thickness skin organ culture model in vitro under serum-free conditions.Q45362284
Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosisQ46824342
Elevated production of melatonin in transgenic rice seeds expressing rice tryptophan decarboxylase.Q53299867
Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin.Q54285483
Melatonin-induced gene expression changes and its preventive effects on adriamycin-induced lipid peroxidation in rat liver.Q54564709
Hyperthermia to normal human skinin vivoupregulates heat shock proteins 27, 60, 72i and 90Q58487561
P433issue1
P921main subjectultraviolet radiationQ11391
inflammationQ101991
melatoninQ180912
keratinocyteQ1473931
P304page(s)117-126
P577publication date2014-12-09
P1433published inJournal of Pineal ResearchQ15056565
P1476titleMelatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes
P478volume58

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cites work (P2860)
Q92703214Age Associated Decrease of MT-1 Melatonin Receptor in Human Dermal Skin Fibroblasts Impairs Protection Against UV-Induced DNA Damage
Q64055404Horse Oil Mitigates Oxidative Damage to Human HaCaT Keratinocytes Caused by Ultraviolet B Irradiation
Q55392528Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/NFkB pathway.
Q46557452Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviol
Q96640091Melatonin induces a stimulatory action on the scrotal skin components of Soay ram in the non-breeding season
Q47272699Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway
Q52759203Melatonin, mitochondria, and the skin.
Q50083062Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
Q51125687Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats.

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