Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model

scientific article published in Nature Communications

Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model is …
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scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9.4560B
P356DOI10.1038/S41467-018-07008-0
P932PMC publication ID6212565
P698PubMed publication ID30385750

P50authorPeter PaleseQ1795041
James DuehrQ37367031
Viviana SimonQ54435264
Matthew J. EvansQ55303072
Victor H Leyva-GradoQ56812339
Mark J. BaileyQ57134671
Julia A BrownQ89453034
Jean K LimQ92004874
Maria Carolina Bermúdez-GonzálezQ92815067
Felix BroeckerQ101244378
Fortuna O ArumemiQ114778833
Florian KrammerQ41531975
Gene S. TanQ47502916
P2093author name stringRong Hai
Harrison Dulin
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Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivoQ24568302
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Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral SerotypeQ26252060
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Antibodies against West Nile Virus Nonstructural Protein NS1 Prevent Lethal Infection through Fc   Receptor-Dependent and -Independent MechanismsQ27472823
Antibody Recognition of Cell Surface-Associated NS1 Triggers Fc- Receptor-Mediated Phagocytosis and Clearance of West Nile Virus-Infected CellsQ27481025
Secreted NS1 of Dengue Virus Attaches to the Surface of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate EQ27481677
Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1Q27486827
Virus-Specific Cytolytic Antibodies to Nonstructural Protein 1 of Japanese Encephalitis Virus Effect Reduction of Virus Output from Infected CellsQ27488397
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An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbationsQ27685255
Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic ReviewQ28114477
Identifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus SpeciesQ28119651
A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responsesQ28954560
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunityQ29196526
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Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and MexicoQ30145646
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Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1.Q33414156
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Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protectionQ36515143
Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer ProtectionQ36991414
Antibody-based assay discriminates Zika virus infection from other flavivirusesQ38157718
Delayed and highly specific antibody response to nonstructural protein 1 (NS1) revealed during natural human ZIKV infection by NS1-based capture ELISA.Q55084361
Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E proteinQ56000963
Zika VirusQ56427410
Protective and immunological behavior of chimeric yellow fever dengue vaccineQ38731663
Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functionsQ38748910
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virusQ38782718
Reduction of yellow fever virus mouse neurovirulence by immunization with a bacterially synthesized non-structural protein (NS1) fragmentQ38930859
Neutralizing human antibodies prevent Zika virus replication and fetal disease in miceQ40052932
Structural Basis of Zika Virus-Specific Antibody ProtectionQ40056291
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activationQ40067512
Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccinationQ40140017
Protection against dengue type 2 virus induced in mice immunized with a DNA plasmid encoding the non-structural 1 (NS1) gene fused to the tissue plasminogen activator signal sequenceQ40500253
The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in miceQ40722416
Passive protection studies in mice with monoclonal antibodies directed against the non-structural protein NS3 of dengue 1 virusQ40764696
Synergistic Interactions of Anti-NS1 Monoclonal Antibodies Protect Passively Immunized Mice from Lethal Challenge with Dengue 2 VirusQ40784132
Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1.Q40798835
Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48.Q40814867
Distinguishing secondary dengue virus infection from Zika virus infection with previous dengue by a combination of three simple serological testsQ41918088
Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum.Q41918245
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in miceQ41919718
A Zika Vaccine Targeting NS1 Protein Protects Immunocompetent Adult Mice in a Lethal Challenge ModelQ43046676
Refined protocol for generating monoclonal antibodies from single human and murine B cellsQ43141303
Humoral Immune Responses Against Zika Virus Infection and the Importance of Preexisting Flavivirus ImmunityQ47558315
Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infection InVitro and in a Mouse ModelQ50052067
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectZika virusQ202864
general chemistryQ909510
P5008on focus list of Wikimedia projectWikiProject Zika CorpusQ54439832
P304page(s)4560
P577publication date2018-11-01
P1433published inNature CommunicationsQ573880
P1476titleHuman antibodies targeting Zika virus NS1 provide protection against disease in a mouse model
P478volume9

Reverse relations

cites work (P2860)
Q90230085An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model
Q63246196Antibodies Elicited by an NS1-Based Vaccine Protect Mice against Zika Virus
Q100736905Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy
Q89920678Crosstalk between RNA Metabolism and Cellular Stress Responses during Zika Virus Replication
Q91711499Defeat Dengue and Zika Viruses With a One-Two Punch of Vaccine and Vector Blockade
Q92364949Development of therapeutic antibodies for the treatment of diseases
Q98578994Enhanced effect of modified Zika virus E antigen on the immunogenicity of DNA vaccine
Q91675204Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein
Q92028890NS1 DNA vaccination protects against Zika infection through T cell-mediated immunity in immunocompetent mice
Q90629764Neutralizing Monoclonal Antibodies against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect from Virus Challenge in a Preclinical Hamster Model
Q66679100The Dual Role of the Antibody Response Against the Flavivirus Non-structural Protein 1 (NS1) in Protection and Immuno-Pathogenesis
Q93078517Therapeutic Advances Against ZIKV: A Quick Response, a Long Way to Go
Q63246368Tracking dengue virus type 1 genetic diversity during lineage replacement in an hyperendemic area in Colombia
Q90692910Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice