Respiratory syncytial virus fusion nanoparticle vaccine immune responses target multiple neutralizing epitopes that contribute to protection against wild-type and palivizumab-resistant mutant virus challenge

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Respiratory syncytial virus fusion nanoparticle vaccine immune responses target multiple neutralizing epitopes that contribute to protection against wild-type and palivizumab-resistant mutant virus challenge is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2018.10.073
P698PubMed publication ID30389195

P50authorNita K. PatelQ87989050
Gale SmithQ106408037
P2093author name stringHanxin Lu
Ye Liu
Gregory Glenn
Pedro A Piedra
Brian E Gilbert
Larry Ellingsworth
Mimi Guebre-Xabier
P2860cites workTwo distinct subtypes of human respiratory syncytial virusQ45848624
Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA ImmunizationQ58780345
Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F proteinQ27335061
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titersQ27667876
Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing EpitopesQ27668015
Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing AntibodyQ27677570
Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adultsQ33555911
Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressureQ33744060
A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion proteinQ33775790
Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusionQ33934074
A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanismQ34492100
Respiratory syncytial virus fusion glycoprotein expressed in insect cells form protein nanoparticles that induce protective immunity in cotton ratsQ34506016
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Molecular evolution of respiratory syncytial virus fusion gene, Canada, 2006-2010.Q35845854
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Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B.Q36348462
Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion proteinQ37732535
Gene sequence variability of the three surface proteins of human respiratory syncytial virus (HRSV) in TexasQ38267482
Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein.Q38394731
Molecular epidemiology and molecular characterization of respiratory syncytial viruses at a tertiary care university hospital in Catalonia (Spain) during the 2013-2014 season.Q39018825
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A Phase 2 randomized, observer-blind, placebo-controlled, dose-ranging trial of aluminum-adjuvanted respiratory syncytial virus F particle vaccine formulations in healthy women of childbearing age.Q40173489
Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutantsQ40528265
Respiratory syncytial virus escape mutant derived in vitro resists palivizumab prophylaxis in cotton ratsQ40588255
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoproteinQ40983230
A Randomized, Blinded, Controlled, Dose-Ranging Study of a Respiratory Syncytial Virus Recombinant Fusion (F) Nanoparticle Vaccine in Healthy Women of Childbearing Age.Q41060727
Modeling maternal fetal RSV F vaccine induced antibody transfer in guinea pigsQ41441320
Enhanced pulmonary pathology associated with the use of formalin-inactivated respiratory syncytial virus vaccine in cotton rats is not a unique viral phenomenonQ41519402
An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunizationQ41721418
In vivo selection of respiratory syncytial viruses resistant to palivizumabQ41891744
ICTV Virus Taxonomy Profile: PneumoviridaeQ45325475
Natural polymorphisms and resistance-associated mutations in the fusion protein of respiratory syncytial virus (RSV): effects on RSV susceptibility to palivizumabQ45360940
Palivizumab-resistant human respiratory syncytial virus infection in infancyQ45375472
Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanismQ45548739
Variable resistance to palivizumab in cotton rats by respiratory syncytial virus mutantsQ45553883
Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a communityQ45753705
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virusQ45759631
Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodiesQ45844409
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectnanoparticleQ61231
P304page(s)8069-8078
P577publication date2018-10-30
P1433published inVaccineQ7907941
P1476titleRespiratory syncytial virus fusion nanoparticle vaccine immune responses target multiple neutralizing epitopes that contribute to protection against wild-type and palivizumab-resistant mutant virus challenge
P478volume36