Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

scientific article published in Nature Communications

Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2018NatCo...9.4624W
P356DOI10.1038/S41467-018-06853-3
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/s41467-018-06853-3
P932PMC publication ID6218470
P698PubMed publication ID30397197

P50authorZhe Bao WuQ81457526
J Y HuangQ86922760
P2093author name stringYu Wang
Yong Zhang
Bing Su
Lei Cao
Hao Tang
Lin Cai
Hong Yao
Gang Yang
Yong Xu Wei
Lichong Yan
Yan Ting Liu
Han Bing Shang
Wei Guo Zhao
Wei Wei Rui
Xiao Biao Zhang
Yu Hang Guo
Ze Rui Wu
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR actionQ24302566
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasisQ24322334
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1rQ24633774
mTOR signaling in growth control and diseaseQ24634174
Long non-coding RNAs: insights into functionsQ28131764
mTOR promotes pituitary tumor development through activation of PTTG1.Q51571729
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.Q51856604
LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern.Q52871265
Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas.Q54168131
Tumour-suppressor activity of H19 RNAQ59071440
The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell DifferentiationQ61645724
Epigenetic lesions at the H19 locus in Wilms' tumour patientsQ72703033
Reduced expression of H19 in bone marrow cells from chronic myeloproliferative disordersQ73230879
Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumorsQ73578095
Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancerQ80287572
Pathogenesis of pituitary tumorsQ83667492
Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.Q38969133
Effects of the estrogen receptor antagonist fulvestrant on F344 rat prolactinoma modelsQ39035803
Dopamine receptor D2S gene transfer improves the sensitivity of GH3 rat pituitary adenoma cells to bromocriptineQ39067641
LncRNA-mediated regulation of cell signaling in cancer.Q39366670
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPsQ39699300
4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosisQ40187965
Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cellsQ40546587
Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesisQ40919536
FKBPs and the Akt/mTOR pathwayQ41779228
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate bindingQ41953170
H19 derived microRNA-675 regulates cell proliferation and migration through CDK6 in gliomaQ42239876
The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.Q42686318
Examination of IGF2 and H19 loss of imprinting in bladder cancer.Q44048722
Determination of subcutaneous tumor size in athymic (nude) miceQ46296687
Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell deathQ46350232
Bromocriptine treatment of invasive giant prolactinomas involving the cavernous sinus: results of a long-term follow up.Q46969695
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and functionQ28204144
4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implicationsQ28240822
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networksQ28255399
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificityQ28262782
Polymorphisms in the H19 gene and the risk of bladder cancerQ28268067
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation eventsQ28281590
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4GQ28285121
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate bindingQ28302887
The H19 locus acts in vivo as a tumor suppressorQ28508794
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptideQ28588606
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40Q29617097
Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancerQ33688617
The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.Q34774397
The antisense transcriptomes of human cellsQ34895481
Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAsQ35125475
Dopamine agonists and pituitary tumor shrinkageQ35259108
Modeling familial cancer with induced pluripotent stem cellsQ35428604
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signalingQ35581650
4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumorsQ35778060
Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinomaQ36243433
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolaseQ36438183
Advances in the treatment of prolactinomasQ36480692
Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergolineQ36629594
Unique expression patterns of H19 in human testicular cancers of different etiology.Q36843920
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translationQ36971030
Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastasesQ37079718
The pathogenesis of pituitary tumorsQ37463057
Cross-Linking Immunoprecipitation and qPCR (CLIP-qPCR) Analysis to Map Interactions Between Long Noncoding RNAs and RNA-Binding ProteinsQ37478468
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasisQ37730639
The H19 locus: role of an imprinted non-coding RNA in growth and development.Q37756737
The PI3K/AKT/mTOR pathway in the pathophysiology and treatment of pituitary adenomasQ38232872
mTOR Signaling in Growth, Metabolism, and Disease.Q38747508
GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signallingQ38837034
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectgeneral chemistryQ909510
P304page(s)4624
P577publication date2018-11-05
P1433published inNature CommunicationsQ573880
P1476titleInhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
P478volume9

Reverse relations

cites work (P2860)
Q90462207Genome-Wide Analysis and Function Prediction of Long Noncoding RNAs in Sheep Pituitary Gland Associated with Sexual Maturation
Q91829521Identification of Transcriptional Metabolic Dysregulation in Subtypes of Pituitary Adenoma by Integrated Bioinformatics Analysis
Q92125695LINC00511 contributes to glioblastoma tumorigenesis and epithelial-mesenchymal transition via LINC00511/miR-524-5p/YB1/ZEB1 positive feedback loop
Q91713405Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer
Q92537519Multiomics-Based Signaling Pathway Network Alterations in Human Non-functional Pituitary Adenomas
Q90580125Novel insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms
Q91070697The Role of Long Noncoding RNAs in the Biology of Pituitary Adenomas

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