Mechanisms of formin-mediated actin assembly and dynamics

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Mechanisms of formin-mediated actin assembly and dynamics is …
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scholarly articleQ13442814

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P356DOI10.1007/S12551-018-0468-6
P932PMC publication ID6297096
P698PubMed publication ID30392063

P50authorNaomi CourtemancheQ89790029
P2093author name stringNaomi Courtemanche
P2860cites workHelical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin.Q55342961
Computational modeling highlights the role of the disordered Formin Homology 1 domain in profilin-actin transfer.Q55668102
Gating mechanisms during actin filament elongation by forminsQ56532488
Mechanistic Differences in Actin Bundling Activity of Two Mammalian Formins, FRL1 and mDia2Q57988077
Poly(L-proline)-binding proteins from chick embryos are a profilin and a profilactinQ69959881
Quantitative analysis of the effect of Acanthamoeba profilin on actin filament nucleation and elongationQ70802575
Structural requirements and thermodynamics of the interaction of proline peptides with profilinQ71955434
Interaction of profilin with G-actin and poly(L-proline)Q72061945
Mechanism of formin-induced nucleation of actin filamentsQ78784392
Rotational movement of the formin mDia1 along the double helical strand of an actin filamentQ82838077
Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factorQ86433879
Effects of Mechanical Stimuli on Profilin- and Formin-Mediated Actin PolymerizationQ89431794
Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivoQ37712462
Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1.Q39372922
INF1 is a novel microtubule-associated forminQ39936118
cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilinQ40897448
Profilin is predominantly associated with monomeric actin in AcanthamoebaQ40922780
Early nucleation events in the polymerization of actin, probed by time-resolved small-angle x-ray scatteringQ41544381
Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assemblyQ41676579
Structure and activity of full-length formin mDia1Q41762564
Computational model of polarized actin cables and cytokinetic actin ring formation in budding yeastQ42232402
Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene.Q42687958
Processive capping by formin suggests a force-driven mechanism of actin polymerizationQ42781194
The Aβ₁₋₄₂ peptide regulates microtubule stability independently of tau.Q42808124
Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell divisionQ43790544
Formin mDia1 senses and generates mechanical forces on actin filamentsQ44189807
F- and G-actin homeostasis regulates mechanosensitive actin nucleation by forminsQ44627297
mDia1 senses both force and torque during F-actin filament polymerization.Q44748459
Actin polymerization-driven molecular movement of mDia1 in living cellsQ44814909
Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysisQ45126402
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domainQ45213799
Drosophila Spire is an actin nucleation factorQ45240490
Elongation of actin filaments is a diffusion-limited reaction at the barbed end and is accelerated by inert macromolecules.Q45242019
Control of the assembly of ATP- and ADP-actin by formins and profilin.Q45345926
Formin differentially utilizes profilin isoforms to rapidly assemble actin filamentsQ46268992
The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1.Q46581093
The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongationQ47251135
Drosophila and human FHOD family formin proteins nucleate actin filaments.Q47414867
Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicityQ47846671
Biphasic Effect of Profilin Impacts the Formin mDia1 Force-Sensing Mechanism in Actin Polymerization.Q47877328
Computational simulation of formin-mediated actin polymerization predicts homologue-dependent mechanosensitivityQ48591142
Non diaphanous formin delphilin acts as a barbed end capping protein.Q50990654
Kinetic evidence for a monomer activation step in actin polymerization.Q52706452
Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1.Q53534430
A novel mechanism for the formation of actin-filament bundles by a nonprocessive formin.Q53594917
Modulation of formin processivity by profilin and mechanical tension.Q55248005
Homozygous loss of DIAPH1 is a novel cause of microcephaly in humansQ23778306
Mutations in the formin gene INF2 cause focal segmental glomerulosclerosisQ24292947
Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.Q24296423
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesisQ24310527
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilinQ24316148
p53-cofactor JMY is a multifunctional actin nucleation factorQ24321681
Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanousQ24324252
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilinQ24624729
Formins and microtubulesQ24634404
Mechanism of activation of the Formin protein Daam1Q24657453
FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugationQ24680239
Structure of the FH2 domain of Daam1: implications for formin regulation of actin assemblyQ24681958
Formins at a glanceQ27009102
Formin and capping protein together embrace the actin filament in a ménage à troisQ27319768
Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed endQ27319951
Individual actin filaments in a microfluidic flow reveal the mechanism of ATP hydrolysis and give insight into the properties of profilinQ27320824
Profilin binds proline-rich ligands in two distinct amide backbone orientationsQ27619025
Crystal structure of human DAAM1 formin homology 2 domainQ27648970
High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASPQ27649039
Incompatibility with Formin Cdc12p Prevents Human Profilin from Substituting for Fission Yeast Profilin: INSIGHTS FROM CRYSTAL STRUCTURES OF FISSION YEAST PROFILINQ27652980
The nature of the globular- to fibrous-actin transitionQ27653487
Crystal Structure of a Complex between Amino and Carboxy Terminal Fragments of mDia1: Insights into Autoinhibition of Diaphanous-Related ForminsQ27664937
FMNL3 FH2–actin structure gives insight into formin-mediated actin nucleation and elongationQ27675412
The structure of crystalline profilin-beta-actinQ27732069
The F-BAR protein Hof1 tunes formin activity to sculpt actin cables during polarized growthQ27929842
Role of formins in actin assembly: nucleation and barbed-end associationQ27934072
Formin Leaky Cap Allows Elongation in the Presence of Tight Capping ProteinsQ27935256
An actin nucleation mechanism mediated by Bni1 and profilinQ27938654
Leiomodin is an actin filament nucleator in muscle cellsQ28117235
The formins: active scaffolds that remodel the cytoskeletonQ28190582
mDia mediates Rho-regulated formation and orientation of stable microtubulesQ28210597
Staying in shape with forminsQ28243355
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerizationQ28247638
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architectureQ28248937
Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cellsQ28254284
Phylogenetic analysis of the formin homology 2 domainQ28290186
Mechanism and function of formins in the control of actin assemblyQ28293947
Thermodynamics and kinetics of actin filament nucleation.Q28344483
Cordon-bleu is an actin nucleation factor and controls neuronal morphologyQ28565024
Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2Q28586134
The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibitionQ28586353
Revisiting the Phylogeny of the Animal Formins: Two New Subtypes, Relationships with Multiple Wing Hairs Proteins, and a Lost Human ForminQ28598048
Interaction of profilin with the barbed end of actin filamentsQ28661688
Regulation of actin filament assembly by Arp2/3 complex and forminsQ29615161
Conserved microtubule-actin interactions in cell movement and morphogenesisQ29615212
A nucleator arms race: cellular control of actin assemblyQ29616146
Conformational changes in actin filaments induced by formin binding to the barbed end.Q30355406
Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and CappuccinoQ30480159
Regulation and targeting of the fission yeast formin cdc12p in cytokinesisQ30481843
Energetic requirements for processive elongation of actin filaments by FH1FH2-forminsQ30487234
The myosin passenger protein Smy1 controls actin cable structure and dynamics by acting as a formin damperQ30503533
Rocket launcher mechanism of collaborative actin assembly defined by single-molecule imagingQ30538297
The role of formin tails in actin nucleation, processive elongation, and filament bundlingQ30596648
Actin cable distribution and dynamics arising from cross-linking, motor pulling, and filament turnoverQ30597660
Accelerated actin filament polymerization from microtubule plus endsQ30832831
Insertional assembly of actin filament barbed ends in association with formins produces piconewton forcesQ31113561
Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeastQ33768492
Formins regulate actin filament flexibility through long range allosteric interactionsQ33835173
Functional cooperation between the microtubule and actin cytoskeletonsQ33840293
Nanostructured self-assembly of inverted formin 2 (INF2) and F-actin-INF2 complexes revealed by atomic force microscopyQ33847676
Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.Q33950254
The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed endsQ34233588
INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathyQ34242050
The mouse formin, FRLalpha, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filamentsQ34301887
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migrationQ34341177
INF2-mediated severing through actin filament encirclement and disruptionQ34397121
INF2 Is a WASP homology 2 motif-containing formin that severs actin filaments and accelerates both polymerization and depolymerization.Q34544252
Dynamic network morphology and tension buildup in a 3D model of cytokinetic ring assemblyQ34628891
Biallelic truncating mutations in FMN2, encoding the actin-regulatory protein Formin 2, cause nonsyndromic autosomal-recessive intellectual disabilityQ34658044
The formin DAD domain plays dual roles in autoinhibition and actin nucleation.Q34683336
Electrostatic interactions between the Bni1p Formin FH2 domain and actin influence actin filament nucleationQ34861129
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complexQ34945496
Unleashing formins to remodel the actin and microtubule cytoskeletonsQ35016805
Structure and function of the interacting domains of Spire and Fmn-family forminsQ35123136
Mechanism and cellular function of Bud6 as an actin nucleation-promoting factor.Q35474950
Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration.Q35564850
Differential interactions of the formins INF2, mDia1, and mDia2 with microtubulesQ35579815
Determinants of Formin Homology 1 (FH1) domain function in actin filament elongation by forminsQ35801835
Assembly and turnover of short actin filaments by the formin INF2 and profilinQ36049928
Regulatory interactions between two actin nucleators, Spire and CappuccinoQ36119528
Formin proteins: a domain-based approach.Q36160324
Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing.Q36298384
A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox.Q36320899
The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilinQ36323549
Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and MotilityQ36510074
Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathyQ36625673
The formin mDia2 stabilizes microtubules independently of its actin nucleation activityQ36625798
Tension modulates actin filament polymerization mediated by formin and profilin.Q36932295
The role of the FH1 domain and profilin in formin-mediated actin-filament elongation and nucleationQ37016416
Model of formin-associated actin filament elongationQ37027224
The role of formins in filopodia formationQ37378128
Review of the mechanism of processive actin filament elongation by forminsQ37491020
Polymerization of actin: mechanism of the Mg2+-induced process at pH 8 and 20 degrees CQ37521711
Interaction between microtubules and the Drosophila formin Cappuccino and its effect on actin assemblyQ37583593
Fifteen formins for an actin filament: a molecular view on the regulation of human formins.Q37681690
Formin' cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamicsQ37688846
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1553-1569
P577publication date2018-11-03
P1433published inBiophysical ReviewsQ26842484
P1476titleMechanisms of formin-mediated actin assembly and dynamics
P478volume10

Reverse relations

cites work (P2860)
Q92705380Arabidopsis Class II Formins AtFH13 and AtFH14 Can Form Heterodimers but Exhibit Distinct Patterns of Cellular Localization
Q89790034Competition for delivery of profilin-actin to barbed ends limits the rate of formin-mediated actin filament elongation
Q91869767Control of actin dynamics during cell motility
Q83230541Formin-2 drives polymerisation of actin filaments enabling segregation of apicoplasts and cytokinesis in
Q92763142Formins, Golgi, and the Centriole
Q91664176Geometrical Constraints Greatly Hinder Formin mDia1 Activity
Q83227351Profilin and formin constitute a pacemaker system for robust actin filament growth
Q91161084The oligodendrocyte growth cone and its actin cytoskeleton: A fundamental element for progenitor cell migration and CNS myelination