Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models

scientific article published on 28 August 2018

Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JACBTS.2018.05.004
P932PMC publication ID6115647
P698PubMed publication ID30175274

P50authorLong-Sheng SongQ59663844
P2093author name stringRong Chen
Kenneth B Margulies
Ryan L Boudreau
Xiaoming Zhang
Cheng Chen
Robert M Weiss
Jennifer Wu
Biyi Chen
William Kutschke
Ang Guo
Chun-Kai Huang
Yihui Wang
Jiang Hong
P2860cites workCysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsQ26771736
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasisQ27302066
Angiotensin-neprilysin inhibition versus enalapril in heart failureQ28247091
Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemiaQ28570460
AutoTT: automated detection and analysis of T-tubule architecture in cardiomyocytesQ33804017
Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress.Q34082800
β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.Q34178045
In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutationQ34313368
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in miceQ34666465
Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failureQ35021746
Tear me down: role of calpain in the development of cardiac ventricular hypertrophyQ35151516
Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodelingQ35191911
In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused heartsQ35575378
Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in CardiomyocytesQ35859516
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide GenerationQ36070582
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarctionQ36201829
Mir-24 regulates junctophilin-2 expression in cardiomyocytesQ36725333
Emerging mechanisms of T-tubule remodelling in heart failureQ36968869
Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx MiceQ37137350
Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal developmentQ37187489
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stressQ37344309
Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female ratsQ37486435
Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.Q37735504
Calpains: an elaborate proteolytic systemQ37921887
The role of calpains in myocardial remodelling and heart failureQ37994503
Delayed, oral pharmacological inhibition of calpains attenuates adverse post-infarction remodellingQ38811003
Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In VivoQ38868395
Calpain research for drug discovery: challenges and potentialQ39004902
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathwayQ41353599
Activity profile of calpains I and II in chronically infarcted rat myocardium--influence of the calpain inhibitor CAL 9961.Q41981503
T-tubule remodeling during transition from hypertrophy to heart failure.Q42488509
Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasisQ42509054
Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure.Q51831539
A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophyQ73957891
Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusionQ83153688
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmurine modelQ122890741
P304page(s)503-517
P577publication date2018-08-28
P1433published inJACC. Basic to Translational ScienceQ27727237
P1476titleTargeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models
P478volume3

Reverse relations

cites work (P2860)
Q58590225E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator
Q90112574Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy
Q89979979Integrin β1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in ARVC
Q92884472Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis
Q99616871Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury
Q99399885Under construction: The dynamic assembly, maintenance, and degradation of the cardiac sarcomere

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