| scholarly article | Q13442814 |
| P50 | author | Christiane Berger-Schaffitzel | Q21256907 |
| Giuseppe Verdile | Q59478595 | ||
| Imre Berger | Q60621105 | ||
| Ralph Martins | Q64367205 | ||
| Miheer Sabale | Q86954845 | ||
| Imran Khan | Q91166835 | ||
| P2093 | author name string | Paul E Fraser | |
| David Groth | |||
| Michael Morici | |||
| Linda Wijaya | |||
| Sudarsan Krishnaswamy | |||
| P2860 | cites work | Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state | Q22254058 |
| Purification and characterization of the human gamma-secretase complex | Q24300026 | ||
| Rat brain gamma-secretase activity is highly influenced by detergents | Q48152408 | ||
| Lessons from a failed γ-secretase Alzheimer trial | Q48449453 | ||
| Baculovirus expression system for heterologous multiprotein complexes. | Q51575215 | ||
| gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. | Q51776761 | ||
| Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. | Q51809948 | ||
| Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. | Q53969139 | ||
| Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue | Q57419126 | ||
| MultiBac: multigene baculovirus-based eukaryotic protein complex production | Q81131931 | ||
| Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase | Q88772876 | ||
| Gamma -secretase inhibitors repress thymocyte development | Q95721445 | ||
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 | ||
| TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity | Q24321405 | ||
| When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease | Q24676480 | ||
| Highly efficient baculovirus-mediated multigene delivery in primary cells | Q27317062 | ||
| Three-dimensional structure of human γ-secretase | Q27684740 | ||
| An atomic structure of human γ-secretase | Q28116260 | ||
| APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes | Q28216835 | ||
| Building gamma-secretase: the bits and pieces | Q28267669 | ||
| Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms | Q28290934 | ||
| Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor | Q28573596 | ||
| Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage | Q28591999 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| New insights into mechanisms of small vessel disease stroke from genetics. | Q30400024 | ||
| Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes | Q31057900 | ||
| Population kinetics during simultaneous infection of insect cells with two different recombinant baculoviruses for the production of rotavirus-like particles | Q33289922 | ||
| Getting a grip on complexes | Q33635370 | ||
| Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution | Q33694348 | ||
| Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate | Q34014078 | ||
| Quantitative proteomics of Spodoptera frugiperda cells during growth and baculovirus infection. | Q34062438 | ||
| Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process | Q34110227 | ||
| SweetBac: a new approach for the production of mammalianised glycoproteins in insect cells. | Q34224840 | ||
| Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin | Q34390470 | ||
| Activation and intrinsic γ-secretase activity of presenilin 1 | Q34410897 | ||
| Liquefaction of Autographa californica nucleopolyhedrovirus-infected insects is dependent on the integrity of virus-encoded chitinase and cathepsin genes | Q34449509 | ||
| γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 | Q34648460 | ||
| Active gamma-secretase complexes contain only one of each component | Q34655171 | ||
| Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules. | Q35023042 | ||
| The dynamic conformational landscape of gamma-secretase. | Q35029189 | ||
| Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes | Q35037737 | ||
| A new glycoengineered insect cell line with an inducibly mammalianized protein N-glycosylation pathway. | Q35703121 | ||
| Comparative proteomics analysis of Spodoptera frugiperda cells during Autographa californica multiple nucleopolyhedrovirus infection | Q35913982 | ||
| Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping. | Q36028390 | ||
| Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease | Q36459592 | ||
| Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase. | Q41447351 | ||
| Probing γ-secretase-substrate interactions at the single amino acid residue level | Q41893383 | ||
| Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles | Q42044384 | ||
| Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons | Q42056692 | ||
| Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein | Q42143882 | ||
| ACEMBLing a multiprotein transmembrane complex: the functional SecYEG-SecDF-YajC-YidC Holotranslocon protein secretase/insertase | Q42149737 | ||
| Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes | Q42162160 | ||
| Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains | Q43259456 | ||
| Nicastrin binds to membrane-tethered Notch | Q43694706 | ||
| gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation | Q44313369 | ||
| Protein complex expression by using multigene baculoviral vectors | Q44583907 | ||
| Gamma-secretase: proteasome of the membrane? | Q44918417 | ||
| Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles | Q45204989 | ||
| Pharmacodynamics of selective inhibition of γ-secretase by avagacestat. | Q45908140 | ||
| In vitro reconstitution of gamma-secretase activity using yeast microsomes | Q46332416 | ||
| Nicastrin functions as a gamma-secretase-substrate receptor | Q46646587 | ||
| Automated unrestricted multigene recombineering for multiprotein complex production | Q47891788 | ||
| Sampling the conformational space of the catalytic subunit of human γ-secretase | Q36479662 | ||
| The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation | Q36562023 | ||
| Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain | Q36563117 | ||
| The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid | Q36582358 | ||
| Protein N-glycosylation in the baculovirus-insect cell expression system and engineering of insect cells to produce "mammalianized" recombinant glycoproteins. | Q36601827 | ||
| Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. | Q37048107 | ||
| Substrate specificity of gamma-secretase and other intramembrane proteases | Q37073568 | ||
| Current concepts in Alzheimer's disease: a multidisciplinary review | Q37360292 | ||
| The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells | Q37401120 | ||
| Signature amyloid β profiles are produced by different γ-secretase complexes | Q37583567 | ||
| The structure and function of Alzheimer's gamma secretase enzyme complex. | Q37643736 | ||
| Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG-SecDF-YajC-YidC. | Q37687646 | ||
| New baculovirus expression tools for recombinant protein complex production | Q37697292 | ||
| The many substrates of presenilin/γ-secretase | Q37845036 | ||
| Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells | Q37855049 | ||
| Assembly of the presenilin γ-/ε-secretase complex. | Q37961796 | ||
| Co-expression vs. co-infection using baculovirus expression vectors in insect cell culture: Benefits and drawbacks | Q37980587 | ||
| Use of baculovirus expression system for generation of virus-like particles: successes and challenges | Q38112493 | ||
| Expression of recombinant antibodies | Q38126016 | ||
| Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution. | Q38433126 | ||
| An Overview and History of Glyco-Engineering in Insect Expression Systems | Q38529958 | ||
| Whole-Genome Sequence of the Spodoptera frugiperda Sf9 Insect Cell Line | Q38694239 | ||
| A draft genome assembly of the army worm, Spodoptera frugiperda | Q38979068 | ||
| A Systematic Review and Critical Evaluation of Reported Pathogenic Sequence Variants in Hidradenitis Suppurativa. | Q39171115 | ||
| Engineering the baculovirus genome to produce galactosylated antibodies in lepidopteran cells | Q39182879 | ||
| Cryo-EM structures of human γ-secretase | Q39383228 | ||
| Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis | Q39695174 | ||
| Towards eukaryotic structural complexomics | Q39916845 | ||
| Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease | Q40055719 | ||
| Multiprotein expression strategy for structural biology of eukaryotic complexes | Q40159891 | ||
| Production of adeno-associated viral vectors in insect cells using triple infection: optimization of baculovirus concentration ratios. | Q40235892 | ||
| Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2. | Q40447108 | ||
| Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. | Q40481796 | ||
| Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop? | Q40555339 | ||
| Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. | Q40583437 | ||
| Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex | Q40600321 | ||
| Gamma-secretase activity is associated with a conformational change of nicastrin | Q40663039 | ||
| The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein | Q40689408 | ||
| The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals | Q40696144 | ||
| Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation | Q40716855 | ||
| Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins | Q40729583 | ||
| The use of baculovirus vectors for the production of membrane proteins in insect cells | Q40877188 | ||
| Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1. | Q40881378 | ||
| Elongation of the N-glycans of fowl plague virus hemagglutinin expressed in Spodoptera frugiperda (Sf9) cells by coexpression of human beta 1,2-N-acetylglucosaminyltransferase I. | Q41221793 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 12834 | |
| P577 | publication date | 2018-08-27 | |
| P1433 | published in | Scientific Reports | Q2261792 |
| P1476 | title | Efficient production of a mature and functional gamma secretase protease | |
| P478 | volume | 8 |
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