Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma

scientific article published on 24 August 2018

Novel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41392-018-0025-6
P932PMC publication ID6107554
P698PubMed publication ID30151243

P50authorXiaoming LyuQ60984544
Yichen LiQ63562510
Ming-Liang HeQ41920677
P2093author name stringYing Chen
Hsiang-Fu Kung
Qi Dong
Liang Dong
Bao Zhang
George G Chen
Paul Lai
Fanghang Zhou
P2860cites workTranscription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndromeQ22010499
A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndromeQ24291857
Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiationQ24298312
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndromeQ24314959
The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndromeQ24540059
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atriaQ24681355
Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndromeQ27638964
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MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2Q28302211
Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expressionQ28505652
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction systemQ28512690
Tbx3 is required for outflow tract developmentQ28590164
Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesisQ28590588
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Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancerQ33261025
The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cupQ33266825
TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation.Q33292102
Tbx3 improves the germ-line competency of induced pluripotent stem cellsQ33983679
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.Q53404327
T-box factors: targeting to chromatin and interaction with the histone H3 N-terminal tail.Q53540820
Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway.Q55278953
Ulnar Mammary syndrome and TBX3: expanding the phenotypeQ84950848
Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survivalQ88435826
TBX2 and TBX3: the special value for anticancer drug targets.Q34125637
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Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinomaQ34452650
Zfx controls the self-renewal of embryonic and hematopoietic stem cells.Q34621247
Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.Q34842421
Overexpression of Tbx3 is correlated with Epithelial-Mesenchymal Transition phenotype and predicts poor prognosis of colorectal cancerQ34991183
The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesisQ35176448
The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancerQ36110675
HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling.Q36724900
Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancerQ36898429
The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancerQ36955132
The effects of genomic polymorphisms in one-carbon metabolism pathways on survival of gastric cancer patients received fluorouracil-based adjuvant therapyQ37125346
The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathwayQ37306208
The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasionQ37364817
Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cellsQ37389160
Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virusQ37412889
Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cellQ37427970
MicroRNAs: potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma.Q37940692
Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkersQ38441606
Tbx3 overexpression in human gastric cancer is correlated with advanced tumor stage and nodal status and promotes cancer cell growth and invasionQ38736567
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Multidimensional optimization of promising antitumor xanthone derivatives.Q39159694
Primate-specific microRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting signal transducer and activator of transcription 3 signaling.Q39496493
TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylasesQ40017336
UV-mediated regulation of the anti-senescence factor Tbx2.Q40048508
Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.Q40174272
The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.Q40752964
Diverse functional networks of Tbx3 in development and diseaseQ42075975
The kringle 1 domain of hepatocyte growth factor has antiangiogenic and antitumor cell effects on hepatocellular carcinoma.Q43797203
Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinomaQ44612966
Ectopic DICER-LIKE1 expression in P1/HC-Pro Arabidopsis rescues phenotypic anomalies but not defects in microRNA and silencing pathwaysQ46744007
Hsc70 regulates the IRES activity and serves as an antiviral target of enterovirus A71 infection.Q47359214
Growth suppressor lingerer regulates bantam microRNA to restrict organ sizeQ47378193
A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancersQ47447879
Retina dorsal/ventral patterning by Xenopus TBX3.Q48871277
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)22
P577publication date2018-08-24
P1433published inSignal Transduction and Targeted TherapyQ108821959
P1476titleNovel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma
P478volume3

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cites work (P2860)
Q89737202EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis
Q90015604Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma
Q81446772The roles and regulation of TBX3 in development and disease.