Missense mutation of VKORC1 leads to medial arterial calcification in rats

scientific article published in Scientific Reports

Missense mutation of VKORC1 leads to medial arterial calcification in rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-018-31788-6
P932PMC publication ID6137107
P698PubMed publication ID30214074

P50authorLeon SchurgersQ60061818
P2093author name stringEtienne Benoit
Virginie Lattard
Arnaud Michaux
Benjamin Matagrin
Jean-Valéry Debaux
P2860cites workVKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection)Q82891113
Vitamin K intake and status are low in hemodialysis patientsQ84251369
Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patientsQ84579705
Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulantsQ84928733
Impaired vitamin K recycling in uremia is rescued by vitamin K supplementationQ87105739
VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activityQ87413629
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapyQ28114887
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2Q28242581
The vitamin K cycleQ28274345
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA proteinQ28304798
Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotypeQ34033497
Association of warfarin use with valvular and vascular calcification: a review.Q34162996
Oral anticoagulant treatment: friend or foe in cardiovascular disease?Q34334786
Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.Q34543641
Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.Q34573161
Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humansQ34618352
Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of ratsQ35008925
Vascular calcification: Mechanisms of vascular smooth muscle cell calcificationQ35553833
Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectivesQ36679917
Vitamin K nutrition, metabolism, and requirements: current concepts and future researchQ36828726
A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant ratsQ37088955
Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cellsQ37100171
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?Q37582670
Role of vitamin K-dependent proteins in the arterial vessel wallQ37895509
Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralizationQ38078666
New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations.Q41261871
Gla-rich protein acts as a calcification inhibitor in the human cardiovascular system.Q41652760
VKORC1 pharmacogenomics summaryQ41968877
Origin of the gender differences of the natural resistance to antivitamin K anticoagulants in ratsQ42488814
Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valvesQ42539622
Does prolonged warfarin exposure potentiate coronary calcification in humans? Results of the warfarin and coronary calcification studyQ43257060
Warfarin use and the risk of valvular calcificationQ43269077
Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: the Rotterdam StudyQ44304946
Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatmentQ44460442
Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney diseaseQ44581119
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney diseaseQ45370236
Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification.Q50357086
Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.Q51102753
Warfarin and vitamin K compete for binding to Phe55 in human VKOR.Q51273552
VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.Q51382670
Establishing a rat model for the study of vitamin K deficiency.Q51723075
Association of VKORC1 -1639 G>A polymorphism with carotid intima-media thickness in type 2 diabetes mellitus.Q54358882
Linkages between Genes for Coat Colour and Resistance to Warfarin in Rattus norvegicusQ54685045
Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in ratsQ56905413
Newly developed model for vitamin K deficiency in germfree miceQ68413986
Warfarin metabolism and vitamin K requirement in the warfarin-resistant ratQ71224892
Effect of feeding vitamin K-deficient diets to female ratsQ79073442
Vitamin K deficiency in rats induced by the feeding of irradiated beefQ79325593
Estimation of warfarin maintenance dose based on VKORC1 (-1639 G>A) and CYP2C9 genotypesQ80352091
Age and dietary form of vitamin K affect menaquinone-4 concentrations in male Fischer 344 ratsQ80738286
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)13733
P577publication date2018-09-13
P1433published inScientific ReportsQ2261792
P1476titleMissense mutation of VKORC1 leads to medial arterial calcification in rats
P478volume8

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cites work (P2860)
Q93102917Establishment of the Variation of Vitamin K Status According to Vkorc1 Point Mutations Using Rat Models
Q91740784The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders

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