Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits

scientific article published in Scientific Reports

Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-018-32042-9
P932PMC publication ID6135829
P698PubMed publication ID30209293

P2093author name stringHidenori Suzuki
Toru Takumi
Masatoshi Nagano
P2860cites workCNV biology in neurodevelopmental disordersQ47865565
WAY-100635 inhibits 8-OH-DPAT-stimulated oxytocin, ACTH and corticosterone, but not prolactin secretionQ47887986
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An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and AutismQ48370596
Early intervention with fluoxetine reverses abnormalities in the serotonergic system and behavior of rats exposed prenatally to dexamethasoneQ48468880
MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635.Q49064161
Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autismQ50312848
Oxytocin receptor blockade reduces acquisition but not retrieval of taste aversion and blunts responsiveness of amygdala neurons to an aversive stimulus.Q50719883
Effects of neonatal oxytocin manipulation on development of social behaviors in mice.Q51831612
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and miceQ86581210
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Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autismQ24599984
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GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of AutismQ28391720
Reversal of social deficits by subchronic oxytocin in two autism mouse modelsQ28394708
Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient ratQ28817783
The neurobiology of pair bondingQ29618579
Oxytocin enables maternal behaviour by balancing cortical inhibitionQ30400698
Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signalingQ33778683
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotoninQ33881046
Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake.Q34157494
The social deficits of the oxytocin knockout mouseQ34930617
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autismQ35838291
Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice onlyQ35954848
Oxytocin receptor knockout mice display deficits in the expression of autism-related behaviorsQ36027211
The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trialQ37199028
Social brains on drugs: tools for neuromodulation in social neuroscienceQ37535877
The conundrums of understanding genetic risks for autism spectrum disordersQ37613535
Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism.Q38967686
Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV miceQ41074513
Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autismQ41256682
Acute SSRI administration affects the processing of social cues in healthy volunteers.Q44259244
Evoked axonal oxytocin release in the central amygdala attenuates fear responseQ44740042
Mice heterozygous for the oxytocin receptor gene (Oxtr(+/-)) show impaired social behaviour but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect.Q46078295
Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in miceQ46116537
Involvement of serotonin and oxytocin in neural mechanism regulating amicable social signal in male mice: Implication for impaired recognition of amicable cues in BALB/c strainQ46403228
Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic BrainQ47650083
Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism.Q47681573
Proton movement and coupling in the POT family of peptide transportersQ47779071
Oxytocin and Serotonin Brain Mechanisms in the Nonhuman Primate.Q47826688
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectautismQ38404
serotoninQ167934
oxytocinQ169960
P304page(s)13675
P577publication date2018-09-12
P1433published inScientific ReportsQ2261792
P1476titleCritical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits
P478volume8

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Q92422430V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: Controllers or Surrogate Markerscites workP2860