Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects

scientific article published in Scientific Reports

Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41598-018-31073-6
P932PMC publication ID6120938
P698PubMed publication ID30177812

P50authorVijayalakshmi RavindranathQ18211727
P2093author name stringFaraz Ahmad
David A Bennett
Debajyoti Das
Reddy Peera Kommaddi
Khader Valli Rupanagudi
Latha Diwakar
Ruturaj Gowaikar
P2860cites workStructure and physiological function of calpainsQ24530607
Brain-Derived Neurotrophic Factor: Three Ligands, Many ActionsQ26795382
Lysosome and calcium dysregulation in Alzheimer's disease: partners in crimeQ27693256
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's diseaseQ48669811
Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by CalpainQ48769291
A rapid method for preparing synaptosomes: comparison, with alternative proceduresQ49135145
Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.Q50763421
Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation.Q52149355
Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to studentsQ28077671
Calpain 1 and Calpastatin expression is developmentally regulated in rat brainQ28584194
Detecting outliers: Do not use standard deviation around the mean, use absolute deviation around the medianQ29029331
Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activationQ30478059
RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemiaQ33912914
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer diseaseQ34107259
Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's diseaseQ35035648
Synaptic therapy in Alzheimer's disease: a CREB-centric approachQ35064948
Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathiesQ35136746
Calpain dysregulation in Alzheimer's diseaseQ35361462
Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.Q35721878
Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liverQ35807544
Overview and findings from the religious orders studyQ36130996
Hippocampal Injections of Oligomeric Amyloid β-peptide (1-42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling PathwayQ36449089
Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylationQ36571781
Calpain and synaptic functionQ36586276
Involvement of calpain activation in neurodegenerative processes.Q36588397
Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brainQ36758446
Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.Q37345165
Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticityQ37661598
Calcium-activated neutral protease (calpain) system: structure, function, and regulationQ37767409
Regulation of calpain-2 in neurons: implications for synaptic plasticityQ37798196
Role of APP and Aβ in synaptic physiologyQ37878495
Structure-function relationships in calpains.Q38049358
Targeting calpain in synaptic plasticityQ38079000
C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A.Q38713373
Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and NeurodegenerationQ38732547
The Study of Postmortem Human Synaptosomes for Understanding Alzheimer's Disease and Other Neurological Disorders: A Review.Q39451622
Preparation of synaptic plasma membrane and postsynaptic density proteins using a discontinuous sucrose gradientQ40043676
Isoform specific function of calpain 2 in regulating membrane protrusionQ40527089
Calpain: new perspectives in molecular diversity and physiological-pathological involvement.Q40694801
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.Q41138030
Activity profile of calpains I and II in chronically infarcted rat myocardium--influence of the calpain inhibitor CAL 9961.Q41981503
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylationQ42917910
Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein.Q44211388
Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease.Q45967931
Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer diseaseQ46060698
Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's diseaseQ48557228
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neuronsQ48589410
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsQ48601563
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)13119
P577publication date2018-09-03
P1433published inScientific ReportsQ2261792
P1476titleIsoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects
P478volume8

Reverse relations

cites work (P2860)
Q124094957Chemical Stimulation of Rodent and Human Cortical Synaptosomes: Implications in Neurodegeneration
Q93197943Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain

Search more.