Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats

Inhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1106032788
P356DOI10.1186/S12890-018-0700-Y
P932PMC publication ID6081862
P698PubMed publication ID30086741

P2093author name stringHong Wang
Jian Xu
Min Yu
Hui Kong
Weiping Xie
Yusheng Cheng
Mengyu He
P2860cites workGenetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary HypertensionQ41283956
Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutationsQ42131816
Role of epidermal growth factor inhibition in experimental pulmonary hypertension.Q43256381
Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 associationQ44613114
Plasmid-based short hairpin RNA against connective tissue growth factor attenuated monocrotaline-induced pulmonary vascular remodeling in ratsQ45867286
The effects of siRNA against RPL22 on ET-1-induced proliferation of human pulmonary arterial smooth muscle cellsQ46712569
Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways.Q51704646
Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.Q54476060
Regulation of the Platelet-derived Growth Factor Receptor-β by G Protein-coupled Receptor Kinase-5 in Vascular Smooth Muscle Cells Involves the Phosphatase Shp2Q64357268
Predominant expression of the src homology 2-containing tyrosine phosphatase protein SHP2 in vascular smooth muscle cellsQ73304067
Management of pulmonary arterial hypertensionQ28081181
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertensionQ33329056
The role of Src homology 2 containing protein tyrosine phosphatase 2 in vascular smooth muscle cell migration and proliferationQ33577586
PK10453, a nonselective platelet-derived growth factor receptor inhibitor, prevents the progression of pulmonary arterial hypertensionQ33805920
Reversal of experimental pulmonary hypertension by PDGF inhibitionQ34048479
PDGF signaling in pulmonary arterial hypertensionQ34048526
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS):Q34491530
Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.Q34557037
Effects of basic fibroblast growth factor and cyclin D1 on cigarette smoke-induced pulmonary vascular remodeling in ratsQ34585197
SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.Q34634255
Role for miR-204 in human pulmonary arterial hypertensionQ34681312
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1Q36178060
PDGF-dependent β-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertensionQ36490514
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.Q36734746
Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.Q36866432
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentiginesQ37137867
Imatinib attenuates monocrotaline pulmonary hypertension and has potent vasodilator activity in pulmonary and systemic vascular beds in the rat.Q37342077
Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.Q37536677
Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalitiesQ37778607
Targeting PDGF pathway in pulmonary arterial hypertensionQ38038222
Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.Q38172724
Leptin signalling system as a target for pulmonary arterial hypertension therapyQ38300615
SHP2 sails from physiology to pathology.Q38580957
Signal Mechanisms of Vascular Remodeling in the Development of Pulmonary Arterial HypertensionQ38602420
Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases.Q38984571
A population-based study of chronic myeloid leukemia patients treated with imatinib in first lineQ39259447
New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signalingQ39419046
Smooth Muscle Insulin-Like Growth Factor-1 Mediates Hypoxia-Induced Pulmonary Hypertension in Neonatal MiceQ39580270
Combined tyrosine and serine/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodelingQ39924433
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectarterial hypertensionQ41861
P304page(s)130
P577publication date2018-08-07
P1433published inBMC Pulmonary MedicineQ15755469
P1476titleInhibition of Shp2 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
P478volume18

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Q90848336Shp2 in myocytes is essential for cardiovascular and neointima developmentcites workP2860

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