Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)

scientific article published on 27 December 2012

Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00430-012-0281-Y
P698PubMed publication ID23269418

P50authorJonathan Charles HowardQ31276181
Klaus PfefferQ39051184
Gereon ScharesQ40808779
P2093author name stringW Däubener
A Hemphill
J Seissler
V Ince
O Degistirici
S K Schmidt
R Meisel
R V Sorg
M Leineweber
D Degrandi
K Spekker
S Brunder
S Stuhlsatz
P2860cites workComparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategyQ21090491
The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineageQ21184175
Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Q22255523
The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expressionQ24671121
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTPQ24679086
Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control itQ27321401
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiQ28476607
Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defenseQ28512319
A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infectionQ28593668
ToxoplasmosisQ30080013
Epidemiology and control of neosporosis and Neospora caninumQ31109044
Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virusQ33177702
Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profileQ33532608
Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophagesQ33766719
The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogensQ33940781
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.Q34325516
In vitro invasion efficiency and intracellular proliferation rate comprise virulence-related phenotypic traits of Neospora caninumQ34639325
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.Q35102296
p47 GTPases: regulators of immunity to intracellular pathogensQ35709631
Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1).Q36041377
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondiiQ36377044
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.Q36874456
Cell-autonomous immunity to Toxoplasma gondii in mouse and man.Q37006950
Mesenchymal stem cells: a new strategy for immunosuppression and tissue repairQ37724579
Immunomodulatory properties and therapeutic application of mesenchymal stem cellsQ37847217
The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondiiQ37904282
Clinical Application of Mesenchymal Stem Cells in the Treatment and Prevention of Graft-versus-Host DiseaseQ37970678
The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferationQ38294345
Indoleamine 2,3-dioxygenase is involved in defense against Neospora caninum in human and bovine cellsQ39822819
Pathogenic characterization in mice of Neospora caninum isolates obtained from asymptomatic calvesQ44460553
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradationQ44786842
MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2.Q46034364
The major 36 kDa Neospora caninum tachyzoite surface protein is closely related to the major Toxoplasma gondii surface antigenQ47996653
A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondiiQ60621617
Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenaseQ61645541
Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginineQ68739930
Toxoplasma gondii Comprises Three Clonal Lineages: Correlation of Parasite Genotype with Human DiseaseQ71829835
Inhibition of T-cell proliferation by murine multipotent mesenchymal stromal cells is mediated by CD39 expression and adenosine generationQ82986187
P433issue3
P921main subjectToxoplasma gondiiQ131003
Neospora caninumQ1431408
P304page(s)197-206
P577publication date2012-12-27
P1433published inMedical Microbiology and ImmunologyQ15760239
P1476titleAntimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)
P478volume202

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cites work (P2860)
Q40076714Effects of Bone Marrow Mesenchymal Stromal Cell Therapy in Experimental Cutaneous Leishmaniasis in BALB/c Mice Induced by Leishmania amazonensis.
Q92822226Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection
Q47103474First Characterization of the Neospora caninum Dense Granule Protein GRA9.
Q64924300Gene expression profiles of germ-free and conventional piglets from the same litter.
Q27323191Identification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance system
Q29994669Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy
Q35967300Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo
Q38749983Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function.
Q40068799The Lymphotoxin β Receptor Is Essential for Upregulation of IFN-Induced Guanylate-Binding Proteins and Survival after Toxoplasma gondii Infection.

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