Essential role of IFN-γ in T cell-associated intestinal inflammation

scientific article published on 20 September 2018

Essential role of IFN-γ in T cell-associated intestinal inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.121886
P932PMC publication ID6237234
P698PubMed publication ID30232288

P50authorTakanori TeshimaQ56654296
Daigo HashimotoQ57031715
Tokiyoshi AyabeQ71605212
Yoshihiro EriguchiQ84112248
Michael E SelstedQ88248606
Yuki YokoiQ91376739
P2093author name stringAndré J Ouellette
Kiminori Nakamura
Shuichiro Takahashi
Rina Sugimoto
P2860cites workPaneth cells: maestros of the small intestinal cryptsQ38080558
The biopsy pathology of non-coeliac enteropathyQ38252412
Lgr5+ stem cells are indispensable for radiation-induced intestinal regenerationQ43548445
Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewalQ43909848
Pediatric autoimmune enteropathy: an entity frequently associated with immunodeficiency disordersQ45006671
R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host diseaseQ46275676
Bactericidal activity of mouse α-defensin cryptdin-4 predominantly affects noncommensal bacteriaQ50044916
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.Q50788436
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins.Q51169431
Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation.Q54283950
Stroma provides an intestinal stem cell niche in the absence of epithelial WntsQ57002669
Subepithelial telocytes are an important source of Wnts that supports intestinal cryptsQ59050075
Debate over the identity of an intestinal niche-cell population settledQ59096496
Renewal of Paneth cells in the small intestine of the mouseQ71284243
Enteropathy with loss of enteroendocrine and paneth cells in a patient with immune dysregulation: a case of adult autoimmune enteropathyQ83152768
Activity of therapeutic JAK 1/2 blockade in graft-versus-host diseaseQ87635679
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteriaQ28204776
An approach to duodenal biopsiesQ28238758
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsQ29616197
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.Q30582106
Gastrointestinal biopsy findings of autoimmune enteropathy: a review of 25 casesQ34173775
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensinQ34186394
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensableQ34217232
Dysbiosis--a consequence of Paneth cell dysfunction.Q35044731
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.Q35655623
Decreased secretion of Paneth cell α-defensins in graft-versus-host diseaseQ35704063
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cellsQ35845010
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).Q36061304
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.Q36069386
IFNγR signaling mediates alloreactive T-cell trafficking and GVHDQ36395621
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cellsQ36553535
Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortalityQ37113096
Enteric defensins are essential regulators of intestinal microbial ecologyQ37483232
P433issue18
P407language of work or nameEnglishQ1860
P577publication date2018-09-20
P1433published inJCI insightQ27727187
P1476titleEssential role of IFN-γ in T cell-associated intestinal inflammation
P478volume3

Reverse relations

cites work (P2860)
Q98612726Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease
Q93088320Human Intestinal Enteroids Model MHC-II in the Gut Epithelium
Q61814273Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease
Q64107046Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
Q94451654Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice

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