Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1

scientific article published on 21 November 2018

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41420-018-0125-7
P932PMC publication ID6249233
P698PubMed publication ID30479840

P50authorSebastian Aguiar BrunemeierQ59176422
Marten P SmidtQ59551353
P2093author name stringLars P van der Heide
Lars von Oerthel
Willemieke M Kouwenhoven
Dorinde S Starmans
Edward J Robinson
P2860cites workMule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosisQ24306444
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2Q24563123
Specification of dopaminergic subsets involves interplay of En1 and Pitx3Q28593766
Parkinson's disease: mechanisms and modelsQ29547424
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitorQ29616727
A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivoQ34241381
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destructionQ34788849
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's diseaseQ35157431
Mcl-1 deficiency results in peri-implantation embryonic lethalityQ35185567
The BCL-2 family reunionQ35568029
Myeloid cell leukemia 1 (Mcl(-1)) protects against 1-methyl-4-phenylpyridinium ion (MPP+) induced apoptosis in Parkinson's diseaseQ35743031
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitizationQ35857019
The ubiquitin E3 ligase parkin regulates the proapoptotic function of BaxQ35925042
Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neuronsQ36560455
Programmed cell death in Parkinson's diseaseQ38036233
The secrets of the Bcl-2 familyQ38039293
Small molecule Mcl-1 inhibitors for the treatment of cancerQ38244767
Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1.Q38934057
Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.Q39696436
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survivalQ39761203
Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine NeuronsQ40592671
Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neuronsQ42322825
Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic developmentQ42356632
Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neuronsQ43564367
The BCL2 code to dopaminergic development and Parkinson's disease.Q46444138
Decreased Mcl-1 protein level in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated miceQ47381832
Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitorsQ48240262
Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats.Q52145827
Developmental cell death in dopaminergic neurons of the substantia nigra of mice.Q52166629
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.Q54679983
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
P304page(s)107
P577publication date2018-01-01
P1433published inCell Death DiscoveryQ27726740
P1476titleSurvival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1
P478volume4

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Q104795238Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunitiescites workP2860

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