CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection

scholarly article by Anthony DiPiazza et al published 1 July 2018 in Journal of Virology

CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.00377-18
P932PMC publication ID6002724
P698PubMed publication ID29669836

P50authorDavid J TophamQ57294998
P2093author name stringAndrea J Sant
Jim Miller
Anthony DiPiazza
Ajitanuj Rattan
Nathan Laniewski
P2860cites workInteraction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organsQ80078362
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Influenza and Memory T Cells: How to Awake the ForceQ28070255
Tissue instruction for migration and retention of TRM cellsQ28083914
Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutininQ30361736
Apoptosis and engulfment by bronchial epithelial cells. Implications for allergic airway inflammation.Q30365916
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FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availabilityQ33580878
Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteinsQ33905228
Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8+ T CellsQ33907800
The pulmonary localization of virus-specific T lymphocytes is governed by the tissue tropism of infectionQ34059082
Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2.Q34469408
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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor bindingQ37266009
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and SpeciesQ37293474
Division of labor between dendritic cell subsets of the lungQ37349753
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Lung niches for the generation and maintenance of tissue-resident memory T cells.Q37662847
CXCR3 ligands: redundant, collaborative and antagonistic functionsQ37827339
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Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virusQ38129084
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TCR signal quantity and quality in CD4(+) T cell differentiation.Q38279985
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Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8+ T-cell immunodominanceQ38957145
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza InfectionQ39056737
CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function.Q39172071
Pulmonary immunity to virusesQ39408047
The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificityQ39553544
Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivoQ40052241
Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis.Q40202770
Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory.Q40474396
Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infectionQ41992035
IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cellsQ43125547
The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate.Q46003771
Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus.Q52721336
Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection.Q53776104
Mechanisms of T cell migration to the lungQ55094003
Trafficking of Th1 cells to lung: a role for selectins and a P-selectin glycoprotein-1-independent ligandQ73812348
Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4Q74638403
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
P304page(s)e00377-18
P577publication date2018-07-01
P1433published inJournal of VirologyQ1251128
P1476titleCD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection
P478volume92