Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking

scientific article published on 12 October 2011

Mapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00894-011-1255-5
P2888exact matchhttps://scigraph.springernature.com/pub.10.1007/s00894-011-1255-5
P698PubMed publication ID21989959

P50authorIlda D'AnnessaQ59680393
Mattia FalconiQ42744422
P2093author name stringDaniele Di Marino
Francesco Oteri
Blasco Morozzo della Rocca
P2860cites workMitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP productionQ70745323
Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimideQ71642286
Kinetic Mechanism of the Exchanges Catalysed by the Adenine-Nucleotide CarrierQ72929321
Binding of the fluorescein derivative eosin Y to the mitochondrial ADP/ATP carrier: characterization of the adenine nucleotide binding siteQ74023958
Folding-unfolding thermodynamics of a beta-heptapeptide from equilibrium simulationsQ74452346
Action of potassium atractylate on oxidative phosphorylation in mitochondria and in submitochondrial particlesQ79435482
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The mechanism of transport by mitochondrial carriers based on analysis of symmetryQ28300538
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibilityQ29547658
Electrostatic funneling of substrate in mitochondrial inner membrane carriersQ30482734
Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondriaQ30493667
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Mitochondrial carriers in the cytoplasmic state have a common substrate binding siteQ34479532
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Sequence anatomy of mitochondrial anion carriersQ35044842
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High-chloride concentrations abolish the binding of adenine nucleotides in the mitochondrial ADP/ATP carrier family.Q37418767
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Neoplastic transformation is associated with coordinate induction of nuclear and cytoplasmic oxidative phosphorylation genesQ41714320
Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform 1 revealed by hydrogen/deuterium exchange coupled to mass spectrometry.Q41811238
ADP/ATP mitochondrial carrier MD simulations to shed light on the structural-dynamical events that, after an additional mutation, restore the function in a pathological single mutantQ42945246
Fluorometric detection of ADP/ATP carrier deficiency in human muscle.Q43744100
Crystallization of the bovine ADP/ATP carrier is critically dependent upon the detergent-to-protein ratioQ44674439
Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnelQ46409451
Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomersQ46754137
Highly conserved charge-pair networks in the mitochondrial carrier familyQ56990020
P433issue6
P304page(s)2377-2386
P577publication date2011-10-12
P1433published inJournal of Molecular ModelingQ1709860
P1476titleMapping multiple potential ATP binding sites on the matrix side of the bovine ADP/ATP carrier by the combined use of MD simulation and docking
P478volume18

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cites work (P2860)
Q95848141A 20/20 view of ANT function in mitochondrial biology and necrotic cell death
Q33792753Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation
Q35580431Mapping conformational heterogeneity of mitochondrial nucleotide transporter in uninhibited states.
Q54966402Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.
Q90748326The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

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