| scholarly article | Q13442814 |
| P356 | DOI | 10.1021/BI00039A008 |
| P698 | PubMed publication ID | 7548002 |
| P50 | author | Roger S. Goody | Q15197765 |
| P2093 | author name string | A Wittinghofer | |
| H Prinz | |||
| C Klebe | |||
| P433 | issue | 39 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 12543-12552 | |
| P577 | publication date | 1995-10-01 | |
| P1433 | published in | Biochemistry | Q764876 |
| P1476 | title | The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1 | |
| P478 | volume | 34 |
| Q42647708 | A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1. |
| Q36324250 | A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo |
| Q42730859 | A pull-down procedure for the identification of unknown GEFs for small GTPases |
| Q30436382 | A systems analysis of importin-{alpha}-{beta} mediated nuclear protein import |
| Q35961166 | Activation of G Proteins by Guanine Nucleotide Exchange Factors Relies on GTPase Activity |
| Q54565581 | Aluminum fluoride associates with the small guanine nucleotide binding proteins. |
| Q24670400 | An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins |
| Q30483270 | Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran |
| Q24676665 | Arabidopsis UVR8 regulates ultraviolet-B signal transduction and tolerance and contains sequence similarity to human regulator of chromatin condensation 1 |
| Q30537389 | Avalanche-like behavior in ciliary import. |
| Q73236658 | Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry |
| Q37388530 | Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain |
| Q24649967 | Biochemical Characterization of the Ran-RanBP1-RanGAP System: Are RanBP Proteins and the Acidic Tail of RanGAP Required for the Ran-RanGAP GTPase Reaction? |
| Q34138530 | CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer. |
| Q40655598 | Caffeine mimics adenine and 2′‐deoxyadenosine, both of which inhibit the guanine‐nucleotide exchange activity of RCC1 and the kinase activity of ATR |
| Q36850952 | Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins |
| Q52729296 | Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. |
| Q39883316 | Cell cycle-dependent binding modes of the ran exchange factor RCC1 to chromatin |
| Q39735696 | Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation |
| Q34160318 | Characterization of a Ras mutant with identical GDP- and GTP-bound structures |
| Q51940416 | Characterization of the activation of the Rap-specific exchange factor Epac by cyclic nucleotides. |
| Q24291170 | Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein |
| Q34591163 | Classical nuclear localization signals: definition, function, and interaction with importin alpha |
| Q44693557 | Comparative functional analysis of the Rac GTPases |
| Q33361958 | Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP |
| Q27642013 | Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2) |
| Q42158425 | Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins |
| Q24561919 | Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1 |
| Q46059326 | Electrostatic control of GTP and GDP binding in the oncoprotein p21ras |
| Q37546997 | Encephalomyocarditis virus leader is phosphorylated by CK2 and syk as a requirement for subsequent phosphorylation of cellular nucleoporins |
| Q40593889 | EspM2 is a RhoA guanine nucleotide exchange factor |
| Q32039456 | Fluorescence methods for monitoring interactions of Rab proteins with nucleotides, Rab escort protein, and geranylgeranyltransferase |
| Q41685068 | GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins |
| Q28141028 | GEFs: structural basis for their activation of small GTP-binding proteins |
| Q35675546 | GrpE, a nucleotide exchange factor for DnaK. |
| Q40526828 | Guanine-nucleotide exchange factor RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase |
| Q33964524 | Herpes simplex virus type 1 entry into host cells: reconstitution of capsid binding and uncoating at the nuclear pore complex in vitro |
| Q28595035 | IIGP1, an Interferon-γ-inducible 47-kDa GTPase of the Mouse, Showing Cooperative Enzymatic Activity and GTP-dependent Multimerization |
| Q24554201 | Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation |
| Q41942681 | Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. |
| Q39716299 | In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1 |
| Q81086826 | In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors |
| Q27680081 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB |
| Q77470794 | Invasion of the nucleotide snatchers: structural insights into the mechanism of G protein GEFs |
| Q37405222 | Kinetic analysis of the guanine nucleotide exchange activity of TRAPP, a multimeric Ypt1p exchange factor |
| Q41915041 | Kinetics of interaction between ADP-ribosylation factor-1 (Arf1) and the Sec7 domain of Arno guanine nucleotide exchange factor, modulation by allosteric factors, and the uncompetitive inhibitor brefeldin A. |
| Q38353916 | Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions |
| Q27937618 | Kinetics of the interactions between yeast elongation factors 1A and 1Balpha, guanine nucleotides, and aminoacyl-tRNA. |
| Q27659930 | Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS |
| Q42733267 | Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). |
| Q55919354 | Moderate discrimination of REP-1 between Rab7⋅GDP and Rab7⋅GTP arises from a difference of an order of magnitude in dissociation rates1 |
| Q34286042 | Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import. |
| Q37386480 | Mss4 does not function as an exchange factor for Rab in endoplasmic reticulum to Golgi transport |
| Q27643786 | NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase |
| Q40719087 | Nd6p, a novel protein with RCC1-like domains involved in exocytosis in Paramecium tetraurelia |
| Q35742955 | New insights into the molecular mechanism of the Rab GTPase Sec4p activation |
| Q64246083 | Novel Ran-RCC1 Inhibitory Peptide-Loaded Nanoparticles Have Anti-Cancer Efficacy In Vitro and In Vivo |
| Q36372013 | Nuclear transport is becoming crystal clear |
| Q36398898 | Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs |
| Q24307945 | Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. |
| Q24316034 | Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells |
| Q50118848 | Purification and biochemical activity of Salmonella exchange factor SopE. |
| Q46939939 | Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b |
| Q73089624 | Purification and characterization of guanine nucleotide dissociation stimulator protein |
| Q34295121 | Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes |
| Q24298767 | Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 |
| Q50719496 | Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. |
| Q24293261 | Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor |
| Q24336127 | Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1 |
| Q34219209 | RanGTP mediates nuclear pore complex assembly |
| Q24318857 | RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange |
| Q93155690 | Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10 |
| Q53278762 | Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells. |
| Q30440076 | Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1. |
| Q30309361 | Regulation of nuclear import and export by the GTPase Ran. |
| Q26825750 | Regulation of small GTPases by GEFs, GAPs, and GDIs |
| Q35610635 | Reversible movement of switch 1 loop of myosin determines actin interaction |
| Q28076332 | Review: Ras GTPases and myosin: Qualitative conservation and quantitative diversification in signal and energy transduction |
| Q27936663 | Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p |
| Q35865695 | Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation |
| Q37163028 | Spatial and temporal coordination of mitosis by Ran GTPase |
| Q37392601 | Spatial distribution and mobility of the Ran GTPase in live interphase cells. |
| Q56288670 | Structural Basis for Activation of ARF GTPase |
| Q24303645 | Structural basis for Rab GTPase activation by VPS9 domain exchange factors |
| Q24291203 | Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1) |
| Q37517662 | Structural mechanisms for regulation of membrane traffic by rab GTPases |
| Q43790564 | Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors |
| Q24301031 | Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor |
| Q27766337 | Structure and mutagenesis of the Dbl homology domain |
| Q42802338 | Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization |
| Q38189984 | TPX2: of spindle assembly, DNA damage response, and cancer |
| Q27748937 | The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller |
| Q44099512 | The CRK1 receptor-like kinase gene of tobacco is negatively regulated by cytokinin |
| Q52722195 | The Interdependent Activation of Son-of-Sevenless and Ras. |
| Q46603162 | The RanGTP gradient - a GPS for the mitotic spindle |
| Q42535999 | The Sec7 Arf-GEF is recruited to the trans-Golgi network by positive feedback. |
| Q27650964 | The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes |
| Q58072247 | The alpha and beta of turning on a molecular switch |
| Q30441924 | The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. |
| Q34156668 | The molecular mechanism of transport of macromolecules through nuclear pore complexes |
| Q36097950 | The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site |
| Q22001446 | The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase |
| Q35088746 | The significance of the free energy of hydrolysis of GTP for signal-transducing and regulatory GTPases |
| Q24320225 | The structural basis of the activation of Ras by Sos |
| Q39262217 | Therapeutic strategies for targeting ras proteins |
| Q46004261 | Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire. |
| Q29615611 | Transport into and out of the nucleus |
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