GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation

scientific article published on 11 December 2018

GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-018-1244-Z
P932PMC publication ID6290009
P698PubMed publication ID30538220

P50authorChen LiangQ57045408
Xianjun YuQ59448483
Yiyin ZhangQ114454531
Si ShiQ38804489
P2093author name stringJiang Liu
Jin Xu
Jie Hua
Quanxing Ni
Qingcai Meng
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatinQ24301757
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyQ24312147
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back UpQ26780372
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell functionQ26865723
HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protectionQ27024339
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsQ28200181
Selenium: Biochemical Role as a Component of Glutathione PeroxidaseQ48014453
Oxidation as a post-translational modification that regulates autophagyQ48405295
Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapiesQ49182137
Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study.Q50520518
AMPK is a direct adenylate charge-regulated protein kinase.Q54580866
Glutathione peroxidase codon 198 polymorphism variant increases lung cancer riskQ73263400
Antioxidant status and oxidative stress markers in pancreatic cancer and chronic pancreatitisQ86543225
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growthQ28262401
Oxidative stress and autophagy: the clash between damage and metabolic needsQ28387805
Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibitionQ28396983
Tissue-specific functions of individual glutathione peroxidasesQ28645787
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagyQ29615616
Autophagy and metabolismQ29615974
The LKB1-AMPK pathway: metabolism and growth control in tumour suppressionQ29617506
Pancreatic cancers require autophagy for tumor growthQ29620331
Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cellsQ30531825
The complex landscape of pancreatic cancer metabolismQ33827703
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinaseQ34236772
Cancer's molecular sweet tooth and the Warburg effect.Q34566915
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.Q34626763
Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic OpportunitiesQ35173610
Regulation and role of autophagy in mammalian cellsQ35869384
Protein oxidation and cellular homeostasis: Emphasis on metabolism.Q36615395
Autophagy: regulation and role in developmentQ37043057
Metabolism addiction in pancreatic cancerQ37620679
Regulation of mammalian autophagy in physiology and pathophysiology.Q37801517
Molecular targets of oxidative stress.Q37839122
Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancerQ38066407
Pancreatic cancer: Current research and future directions.Q38705681
Modifiable and non-modifiable risk factors for pancreatic cancer: A reviewQ38909631
Regulation of autophagy by cytosolic acetyl-coenzyme A.Q39021728
Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cellsQ39133347
Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancerQ39638465
Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II.Q40044375
Under the ROS…thiol network is the principal suspect for autophagy commitmentQ42966653
Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variantQ44973563
Hypoxic cervical cancers with low apoptotic index are highly aggressive.Q45128481
Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.Q46003361
Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk.Q46532444
MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effectQ46864171
Cancer statistics, 2018.Q47191906
Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinaseQ47918672
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
pancreatic cancerQ212961
autophagyQ288322
immunologyQ101929
P304page(s)1187
P577publication date2018-12-11
P1433published inCell Death and DiseaseQ2197222
P1476titleGPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation
P478volume9

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cites work (P2860)
Q101238674Galectin-3 Expression in Pancreatic Cell Lines Under Distinct Autophagy-Inducing Stimulus
Q91896797Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy

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