| P50 | author | Antonella Ragnini | Q43159724 |
| P2093 | author name string | Alice Del Giovane | |
| P2860 | cites work | GDC-0449-a potent inhibitor of the hedgehog pathway | Q39806626 |
| | Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells | Q39942187 |
| | Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog | Q39974691 |
| | Characterization of two patched receptors for the vertebrate hedgehog protein family | Q22007983 |
| | The crosstalk of mTOR/S6K1 and Hedgehog pathways | Q24308749 |
| | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth | Q24309283 |
| | Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation | Q24311395 |
| | Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis | Q24315133 |
| | Mutation in GLI3 in postaxial polydactyly type A | Q24323153 |
| | The hedgehog receptor patched is involved in cholesterol transport | Q24338297 |
| | Small molecule modulation of Smoothened activity | Q24540343 |
| | Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists | Q24632161 |
| | Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination | Q24657511 |
| | Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened | Q24682703 |
| | Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists | Q24794838 |
| | Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors | Q26764892 |
| | Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation | Q27302125 |
| | Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination | Q27303918 |
| | Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. | Q27314615 |
| | Structure of the human smoothened receptor bound to an antitumour agent | Q27677951 |
| | Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling | Q27680483 |
| | Mutations in the human Sonic Hedgehog gene cause holoprosencephaly | Q28116314 |
| | Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation | Q28139169 |
| | Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1 | Q28204504 |
| | Sonic hedgehog induces the segregation of patched and smoothened in endosomes | Q28214997 |
| | Mechanisms and functions of Hedgehog signalling across the metazoa | Q28235875 |
| | Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo | Q28237073 |
| | A genetic screen identifies genes essential for development of myelinated axons in zebrafish | Q28254773 |
| | In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog | Q28275763 |
| | Structural basis of Smoothened regulation by its extracellular domains | Q28277263 |
| | Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon | Q28505386 |
| | mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells. | Q50629123 |
| | The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis. | Q50647225 |
| | Point mutations in human GLI3 cause Greig syndrome. | Q52192748 |
| | Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination. | Q55073612 |
| | Role and inhibition of GLI1 protein in cancer. | Q55384318 |
| | GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families | Q55670532 |
| | Structures of human Patched and its complex with native palmitoylated sonic hedgehog | Q59067869 |
| | Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination | Q59093298 |
| | Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer | Q83184162 |
| | Structural Basis of Smoothened Activation in Hedgehog Signaling | Q88876114 |
| | Efficient manipulation of Hedgehog/GLI signaling using retroviral expression systems. | Q40047976 |
| | A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51). | Q40714889 |
| | Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling | Q41175659 |
| | Genetic activation of Hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions. | Q42108815 |
| | CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes | Q42140671 |
| | Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells | Q42165194 |
| | Discovery and exploitation of novel targets by approved drugs | Q42453604 |
| | Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals | Q42455142 |
| | TGFβ lengthens the G1 phase of stem cells in aged mouse brain. | Q44276313 |
| | Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination. | Q45121290 |
| | The quest for myelin in the adult brain | Q45773513 |
| | Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. | Q45985961 |
| | Sonic hedgehog promotes the generation of myelin proteins by transplanted oligosphere-derived cells. | Q45995063 |
| | Cholesterol regulates the endoplasmic reticulum exit of the major membrane protein P0 required for peripheral myelin compaction. | Q46013936 |
| | Sonic hedgehog (SHH) mutation in patients within the spectrum of holoprosencephaly. | Q46034684 |
| | High cholesterol level is essential for myelin membrane growth | Q46406733 |
| | Inhibition of Notch signaling enhances tissue repair in an animal model of multiple sclerosis. | Q46806244 |
| | The role of the Hedgehog signaling pathway in cancer: A comprehensive review | Q47258866 |
| | Role of Sonic Hedgehog Signaling in Oligodendrocyte Differentiation. | Q47391718 |
| | Postnatal Sonic hedgehog (Shh) responsive cells give rise to oligodendrocyte lineage cells during myelination and in adulthood contribute to remyelination | Q47632981 |
| | GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis-van Creveld syndrome. | Q47706903 |
| | On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function | Q47889758 |
| | Novel heterozygous nonsense GLI2 mutations in patients with hypopituitarism and ectopic posterior pituitary lobe without holoprosencephaly. | Q48100245 |
| | Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. | Q48199490 |
| | Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone. | Q48422550 |
| | Motor skill learning requires active central myelination. | Q48482406 |
| | Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle. | Q48485513 |
| | Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells | Q48950835 |
| | Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging | Q50048659 |
| | Myelin plasticity and behaviour-connecting the dots | Q50061569 |
| | Gli1 can rescue the in vivo function of Gli2 | Q28506239 |
| | Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation | Q28507411 |
| | All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 | Q28508067 |
| | Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain | Q28508935 |
| | Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development | Q28509768 |
| | Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation | Q28551761 |
| | Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation | Q28568907 |
| | Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo | Q28572747 |
| | Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 | Q28646392 |
| | A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene | Q28646525 |
| | Activation of a metabolic gene regulatory network downstream of mTOR complex 1 | Q29615179 |
| | Hedgehog: functions and mechanisms | Q29619190 |
| | Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. | Q30513975 |
| | Retinoid X receptor gamma signaling accelerates CNS remyelination | Q33580095 |
| | Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis | Q33698346 |
| | Mapping infant brain myelination with magnetic resonance imaging | Q33791700 |
| | Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine | Q33927093 |
| | Comparison of cortical and white matter traumatic brain injury models reveals differential effects in the subventricular zone and divergent Sonic hedgehog signaling pathways in neuroblasts and oligodendrocyte progenitors | Q34295157 |
| | Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice | Q34338310 |
| | A regenerative approach to the treatment of multiple sclerosis | Q34376469 |
| | The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type-A/B; No phenotype prediction from the position of GLI3 mutations | Q34390140 |
| | Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo | Q34472745 |
| | Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome. | Q34505830 |
| | Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling | Q34574774 |
| | Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin | Q34672075 |
| | Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging | Q34910907 |
| | Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. | Q34981146 |
| | Patched regulates Smoothened trafficking using lipoprotein-derived lipids. | Q35012457 |
| | Mosaic analysis with double markers reveals tumor cell of origin in glioma | Q35127020 |
| | Mediators of oligodendrocyte differentiation during remyelination | Q35173135 |
| | Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling | Q35665909 |
| | Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors | Q35684546 |
| | Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. | Q35722779 |
| | HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity | Q35757997 |
| | Cooperative Hedgehog-EGFR signaling | Q35772768 |
| | CNS myelin wrapping is driven by actin disassembly | Q35901012 |
| | AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma | Q35906944 |
| | Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened | Q35987233 |
| | A culture system to study oligodendrocyte myelination processes using engineered nanofibers. | Q36208041 |
| | Diversity Matters: A Revised Guide to Myelination | Q36505475 |
| | Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. | Q36793938 |
| | Clobetasol promotes remyelination in a mouse model of neuromyelitis optica | Q36836541 |
| | GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation | Q37075682 |
| | Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features | Q37089385 |
| | Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination | Q37146268 |
| | Regulation of ceramide biosynthesis by TOR complex 2. | Q37439524 |
| | Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. | Q37441853 |
| | Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system | Q37573627 |
| | Notch: a new player in MS mechanisms | Q37596103 |
| | Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. | Q37663142 |
| | Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. | Q37663145 |
| | Regulation of cholesterol and fatty acid synthesis | Q37866898 |
| | The Hedgehog's tale: developing strategies for targeting cancer | Q37879912 |
| | The mechanisms of Hedgehog signalling and its roles in development and disease | Q38110420 |
| | White matter plasticity in adulthood. | Q38155709 |
| | Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer | Q38194710 |
| | Hedgehog and its circuitous journey from producing to target cells | Q38226248 |
| | Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. | Q38289361 |
| | Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo | Q38339593 |
| | Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish. | Q38444377 |
| | Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology | Q38538932 |
| | Myelin regulatory factor drives remyelination in multiple sclerosis | Q38718081 |
| | Pushing Forward: Remyelination as the New Frontier in CNS Diseases | Q38768775 |
| | Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. | Q39187240 |
| | Chemical inducers and transcriptional markers of oligodendrocyte differentiation | Q39693671 |
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | membrane protein | Q423042 |
| | demyelinating disease | Q1186703 |
| | cell surface receptor | Q2476074 |
| | pathology | Q7208 |
| | nervous system | Q9404 |
| | molecular biology | Q7202 |
| | recovery of function | Q60345466 |
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 3677 | |
| P577 | publication date | 2018-11-20 | |
| P1433 | published in | International Journal of Molecular Sciences | Q3153277 |
| P1476 | title | Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies | |
| P478 | volume | 19 | |