Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs

Broadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1110155356
P356DOI10.1038/S41541-018-0093-1
P932PMC publication ID6265323
P698PubMed publication ID30510776

P50authorXavier SaelensQ8043303
P2093author name stringT U Vogel
T Ysenbaert
H Kleanthous
A Smet
E O Oloo
E R Job
I Christopoulou
R P Oomen
T Strugnell
P2860cites workA generic system for the expression and purification of soluble and stable influenza neuraminidaseQ21091069
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Molecular basis for broad neuraminidase immunity: conserved epitopes in seasonal and pandemic H1N1 as well as H5N1 influenza virusesQ28387782
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Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccinesQ30356933
Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza InfectionQ57077389
Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequencesQ84557620
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Cocktail of H5N1 COBRA HA vaccines elicit protective antibodies against H5N1 viruses from multiple clades.Q30371649
Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses.Q30384878
Universal influenza vaccines: Shifting to better vaccines.Q30386388
Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategiesQ30386823
Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferretsQ30392305
Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus StrainsQ30396097
Influenza neuraminidase-inhibiting antibodies are induced in the presence of zanamivirQ30399269
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Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaquesQ30427950
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Human cytotoxic T-lymphocyte repertoire to influenza A virusesQ33785232
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Glycosylation site alteration in the evolution of influenza A (H1N1) virusesQ33987971
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Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza seasonQ34480810
Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomersQ35139986
A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibodyQ35225083
Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice.Q35677624
Influenza neuraminidaseQ35791130
Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protectionQ36515143
Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge ModelQ37123064
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virusQ37369509
Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studiesQ38803189
A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in miceQ39048437
Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes.Q40075978
Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell InfiltrationQ40207930
Differences in clinical features between influenza A H1N1, A H3N2, and B in adult patientsQ40558910
A 2 (N2) neuraminidase of the X-7 influenza virus recombinant: determination of molecular size and subunit composition of the active unitQ40636448
An optimized enzyme-linked lectin assay to measure influenza A virus neuraminidase inhibition antibody titers in human seraQ42186897
Genetic analysis and evaluation of the reassortment of influenza B viruses isolated in Taiwan during the 2004-2005 and 2006-2007 epidemics.Q43175970
Immunoinformatic comparison of T-cell epitopes contained in novel swine-origin influenza A (H1N1) virus with epitopes in 2008-2009 conventional influenza vaccineQ45382232
Inactivated influenza H5N1 whole-virus vaccine with aluminum adjuvant induces homologous and heterologous protective immunities against lethal challenge with highly pathogenic H5N1 avian influenza viruses in a mouse modelQ45407370
Antibodies directed towards neuraminidase N1 control disease in a mouse model of influenzaQ47426452
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)55
P577publication date2018-01-01
P1433published inNPJ VaccinesQ30275609
P1476titleBroadened immunity against influenza by vaccination with computationally designed influenza virus N1 neuraminidase constructs
P478volume3

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cites work (P2860)
Q89965369Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics
Q92376654Computational Approaches and Challenges to Developing Universal Influenza Vaccines
Q92376471Extending the Stalk Enhances Immunogenicity of the Influenza Virus Neuraminidase
Q91925447Neuraminidase expressing virus-like particle vaccine provides effective cross protection against influenza virus
Q89723360Next-generation influenza vaccines: opportunities and challenges

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