A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3 is …
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scholarly articleQ13442814

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P5530Altmetric DOI10.1016/J.REDOX.2018.06.008
P6179Dimensions Publication ID1105223716
P356DOI10.1016/J.REDOX.2018.06.008
P953full work available at URLhttp://eprints.whiterose.ac.uk/133158
P6366Microsoft Academic ID2810728092
P932PMC publication ID6067063
P698PubMed publication ID30007887
P1154Scopus EID2-s2.0-85049758638

P50authorThomas W SmithQ61847239
P2093author name stringSherif F El-Khamisy
Michael P Williamson
Robert K Poole
Peter J F Henderson
Michael Hippler
Clare R Trevitt
Hannah M Southam
Chunyan Liao
Francesca L Cox
Jonathan A Chapman
Laurence A Middlemiss
Rhiannon L Lyon
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Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in miceQ36183586
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Carbon Monoxide Gas Is Not Inert, but Global, in Its Consequences for Bacterial Gene Expression, Iron Acquisition, and Antibiotic ResistanceQ37040059
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CO-releasing Metal Carbonyl Compounds as Antimicrobial Agents in the Post-antibiotic Era.Q38521451
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Analysis of the bacterial response to Ru(CO)3Cl(Glycinate) (CORM-3) and the inactivated compound identifies the role played by the ruthenium compound and reveals sulfur-containing species as a major target of CORM-3 actionQ39454958
Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in miceQ39889877
A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemiaQ39903621
CO-Releasing Molecules Have Nonheme Targets in Bacteria: Transcriptomic, Mathematical Modeling and Biochemical Analyses of CORM-3 [Ru(CO)3Cl(glycinate)] Actions on a Heme-Deficient Mutant of Escherichia coliQ41362779
Gaseous Mediators and Mitochondrial Function: The Future of Pharmacologically Induced Suspended Animation?Q41819432
Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo'' to inhibition by the carbon monoxide-releasing molecule, CORM-3: N-acetylcysteine reduces CO-RM uptake and inhibition of respiration.Q41901853
Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coliQ42037077
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Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing moleculeQ42486556
Reactive oxygen species mediate bactericidal killing elicited by carbon monoxide-releasing moleculesQ42841026
Sulfite species enhance carbon monoxide release from CO-releasing molecules: implications for the deoxymyoglobin assay of activity.Q44087300
Transcriptional responses of Escherichia coli to S-nitrosoglutathione under defined chemostat conditions reveal major changes in methionine biosynthesisQ45221652
In vitro and in vivo effects of the carbon monoxide-releasing molecule, CORM-3, in the xenogeneic pig-to-primate context.Q46037822
Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coliQ46107296
Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometryQ50425230
Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities.Q53674243
Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators.Q54412235
New insights into the chemistry of fac-[Ru(CO)3]2+ fragments in biologically relevant conditions: The CO releasing activity of [Ru(CO)3Cl2(1,3-thiazole)], and the X-ray crystal structure of its adduct with lysozymeQ58326608
Differential Antibacterial Activity Against Pseudomonas aeruginosa by Carbon Monoxide-Releasing MoleculesQ61837655
Analysis in vivo of antitumor activity, cytotoxicity and Interaction between plasmid DNA and the cis-dichloro-tetra-amine-ruthenium(III) chlorideQ79972288
Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metalQ87164363
P407language of work or nameEnglishQ1860
P304page(s)114-123
P577publication date2018-09-01
P1433published inRedox BiologyQ27724751
P1476titleA thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3
P478volume18