Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

scientific article published in PLoS ONE

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0209150
P932PMC publication ID6296660
P698PubMed publication ID30557391

P50authorSerena PavoniQ90584648
Ferid NassorQ90584652
Steve CottinQ90584657
Frank YatesQ90584659
P2093author name stringJean-Philippe Deslys
Jacqueline Mikol
Aloïse Mabondzo
Rafika Jarray
Anne-Cécile Guyot
Jessica Rontard
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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioQ24298670
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Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Q28828789
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Beta-amyloid oligomers and cellular prion protein in Alzheimer's diseaseQ33757721
Soluble amyloid beta levels are elevated in the white matter of Alzheimer's patients, independent of cortical plaque severityQ34100175
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesisQ34480339
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Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderlyQ37391300
Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's DiseaseQ37489141
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Animal models of Alzheimer disease: historical pitfalls and a path forwardQ38209146
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NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synucleinQ38562137
Generating CNS organoids from human induced pluripotent stem cells for modeling neurological disordersQ38659708
An update on stem cell biology and engineering for brain developmentQ38735486
Organoids as an in vitro model of human development and disease.Q38748913
Epigenetic Mechanisms of Longevity and Aging.Q38926028
A three-dimensional human neural cell culture model of Alzheimer's diseaseQ42069680
Cell diversity and network dynamics in photosensitive human brain organoids.Q42615577
The prion protein gene: a role in mouse embryogenesis?Q43408865
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsivenessQ45736205
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
organoidQ11293125
P304page(s)e0209150
P577publication date2018-12-17
P1433published inPLOS OneQ564954
P1476titleSmall-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes
P478volume13

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cites work (P2860)
Q98945390Innovative Therapies and Nanomedicine Applications for the Treatment of Alzheimer's Disease: A State-of-the-Art (2017-2020)
Q89963823Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease
Q92000754Modeling and Targeting Alzheimer's Disease With Organoids
Q97066898Retinal and Brain Organoids: Bridging the Gap Between in vivo Physiology and in vitro Micro-Physiology for the Study of Alzheimer's Diseases
Q93075253Screening of pure synthetic coating substrates for induced pluripotent stem cells and iPSC-derived neuroepithelial progenitors with short peptide based integrin array
Q63740571The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration

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