Identifying mouse developmental essential genes using machine learning

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Identifying mouse developmental essential genes using machine learning is …
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scholarly articleQ13442814

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P356DOI10.1242/DMM.034546
P932PMC publication ID6307915
P698PubMed publication ID30563825

P50authorGeorge TzotzosQ52610293
Andrew J DoigQ42547635
Kathryn E HentgesQ47164161
P2093author name stringDavid Tian
Mitra Kabir
Stephanie Wenlock
P2860cites workGene essentiality, gene duplicability and protein connectivity in human and mouseQ51708452
Computing topological parameters of biological networksQ51900389
Database resources of the National Center for Biotechnology InformationQ57444434
Bacillus subtilis and Escherichia coli essential genes and minimal cell factories after one decade of genome engineeringQ22065908
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genesQ24597048
The mammalian gene function resource: the International Knockout Mouse ConsortiumQ24631451
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics ProjectQ24631734
Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping ConsortiumQ24631763
STRING 8--a global view on proteins and their functional interactions in 630 organismsQ24656073
Defining the Role of Essential Genes in Human DiseaseQ24810356
WebGestalt: an integrated system for exploring gene sets in various biological contextsQ24813284
The role of the ubiquitin proteasome system in cerebellar development and medulloblastomaQ26782159
Analysis of protein-coding genetic variation in 60,706 humansQ26831376
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
EMBOSS: the European Molecular Biology Open Software SuiteQ27860491
A DNA helicase required for maintenance of the functional mitochondrial genome in Saccharomyces cerevisiaeQ27930399
Functional genetic analysis of mouse chromosome 11Q28204984
The mouse ascending: perspectives for human-disease modelsQ28244127
Ensembl 2016Q28603093
Integration of biological networks and gene expression data using CytoscapeQ28681323
Gene essentiality and synthetic lethality in haploid human cellsQ28771731
SignalP 4.0: discriminating signal peptides from transmembrane regionsQ29547202
UniProt: a hub for protein informationQ29547457
Ensembl 2015Q29615570
A systematic survey of loss-of-function variants in human protein-coding genesQ29615756
Topological analysis and interactive visualization of biological networks and protein structuresQ30414346
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping dataQ30441320
Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutationsQ30502995
MouseMine: a new data warehouse for MGI.Q30975461
The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence AnalysesQ31109176
Identifying tissue-enriched gene expression in mouse tissues using the NIH UniGene database.Q33202708
Towards the identification of essential genes using targeted genome sequencing and comparative analysisQ33260930
Regional variation in the density of essential genes in miceQ33283731
Analysis and identification of essential genes in humans using topological properties and biological informationQ38473189
Accurate prediction of human essential genes using only nucleotide composition and association information.Q38980559
The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessibleQ39125771
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinityQ40244307
Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous familiesQ41392829
Predicting essential genes in fungal genomesQ43055610
Sequence-based information-theoretic features for gene essentiality prediction.Q45944041
Gene essentiality prediction based on fractal features and machine learning.Q45948672
An integrated machine-learning model to predict prokaryotic essential genes.Q45955127
Predicting essential genes based on network and sequence analysis.Q45963787
Human gene essentialityQ46065137
The UCSC Genome Browser database: 2018 updateQ46557670
Effective identification of essential proteins based on priori knowledge, network topology and gene expressionsQ46928057
Emerging and evolving concepts in gene essentiality.Q47443193
A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.Q49720448
Understanding network concepts in modulesQ33286658
Towards the prediction of essential genes by integration of network topology, cellular localization and biological process informationQ33503874
Identifying essential genes in bacterial metabolic networks with machine learning methodsQ33570986
Rational association of genes with traits using a genome-scale gene network for Arabidopsis thalianaQ33801141
Null mutations in human and mouse orthologs frequently result in different phenotypesQ34011529
Training set selection for the prediction of essential genesQ34039685
An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential GenesQ34044471
Identification and characterization of essential genes in the human genome.Q34045164
An Approach for Predicting Essential Genes Using Multiple Homology Mapping and Machine Learning AlgorithmsQ34047417
Mouse genetics: catalogue and scissorsQ34049178
On the Use of Gene Ontology Annotations to Assess Functional Similarity among Orthologs and Paralogs: A Short ReportQ34167857
Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic dataQ34196685
Online predicted human interaction databaseQ34385609
A mouse geneticist's practical guide to CRISPR applicationsQ34441174
OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disordersQ34449729
Identification of a large set of rare complete human knockoutsQ34468556
Mouse genome database 2016.Q34502040
Investigating the predictability of essential genes across distantly related organisms using an integrative approachQ34559562
cytoHubba: identifying hub objects and sub-networks from complex interactomeQ34913959
Prediction of essential proteins based on gene expression programmingQ35051017
A new computational strategy for predicting essential genes.Q35073769
Predicting bacterial essential genes using only sequence composition information.Q35208844
OGEE: an online gene essentiality databaseQ35630912
Homozygous loss-of-function variants in European cosmopolitan and isolate populationsQ36065471
The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesisQ36305395
Selection of key sequence-based features for prediction of essential genes in 31 diverse bacterial speciesQ36328201
From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic dataQ36364750
Properties of genes essential for mouse developmentQ36386280
PANTHER version 10: expanded protein families and functions, and analysis tools.Q36434795
Hubba: hub objects analyzer--a framework of interactome hubs identification for network biologyQ36749291
High-throughput discovery of novel developmental phenotypesQ37629635
Predicting essential genes for identifying potential drug targets in Aspergillus fumigatusQ38191080
g:Profiler--a web-based toolset for functional profiling of gene lists from large-scale experimentsQ38302104
Characteristics of Plant Essential Genes Allow for within- and between-Species Prediction of Lethal Mutant PhenotypesQ38458907
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesmachine learningQ2539
CytoscapeQ3699942
Bayes' theoremQ182505
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectmachine learningQ2539
P304page(s)dmm034546
P577publication date2018-12-13
P1433published inDisease Models & MechanismsQ1524006
P1476titleIdentifying mouse developmental essential genes using machine learning
P478volume11

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cites work (P2860)
Q91641872Essential gene prediction in Drosophila melanogaster using machine learning approaches based on sequence and functional features
Q91834102Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases
Q92852489Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

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