Abstract is: Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. Some viruses have evolved defense mechanisms that regulate and interfere with IRF functions to escape the host immune system. For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. The Kaposi sarcoma herpesvirus, KSHV, is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity. In addition, the expression of IRF genes is under epigenetic regulation by promoter DNA methylation.
protein family associated with domain | Q81505329 |
protein | Q8054 |
transcription cis-regulatory region binding protein | Q106952392 |
P646 | Freebase ID | /m/02p9g7z |
P2926 | InterPro ID | IPR001346 |
P486 | MeSH descriptor ID | D050835 |
P672 | MeSH tree code | D12.644.360.024.302 |
D12.776.157.057.050 | ||
D12.776.260.504 | ||
D12.776.476.024.385 | ||
D12.776.930.332 | ||
P6366 | Microsoft Academic ID | 9173399 |
P10283 | OpenAlex ID | C9173399 |
P2892 | UMLS CUI | C1564741 |
P527 | has part(s) | Interferon regulatory factor DNA-binding domain | Q24783071 |
P680 | molecular function | transcription cis-regulatory region binding | Q14864804 |
Q23431459 | Aminopeptidase AHA_1753 |
Q23432114 | Aminopeptidase AHA_1754 |
Q24127697 | Aminopeptidase B EAE_00750 |
Q22162386 | Aminopeptidase B ECIAI39_2724 |
Q24132168 | Aminopeptidase B ECL_03872 |
Q24149848 | Aminopeptidase B ECUMN_2843 |
Q24271702 | Aminopeptidase B KPHS_39260 |
Q24151969 | Aminopeptidase B NRG857_12555 |
Q24282066 | Aminopeptidase B O3K_06800 |
Q23424975 | Aminopeptidase B YE1064 |
Q24140716 | Aminopeptidase B b2523 |
Q24145513 | Aminopeptidase ECs3389 |
Q23599569 | Aminopeptidase PepB SO_0876 |
Q23558579 | Aminopeptidase PepB STM2536 |
Q27474880 | Aminopeptidase SDY_2719 |
Q23420920 | Aminopeptidase SF2570 |
Q23435530 | Aminopeptidase VC0755 |
Q23437751 | Aminopeptidase VF_0624 |
Q23443082 | Aminopeptidase VP0603 |
Q28770681 | Aminopeptidase YPO2889 |
Q28561722 | Interferon regulatory factor 1 |
Q21173368 | Interferon regulatory factor 1 |
Q21986018 | Interferon regulatory factor 1 |
Q29831720 | Interferon regulatory factor 1a |
Q29825314 | Interferon regulatory factor 1b |
Q21140844 | Interferon regulatory factor 2 |
Q21986020 | Interferon regulatory factor 2 |
Q29522376 | Interferon regulatory factor 3 |
Q29835368 | Interferon regulatory factor 3 |
Q5973468 | Interferon regulatory factor 3 |
Q14914341 | Interferon regulatory factor 3 |
Q21138133 | Interferon regulatory factor 3 |
Q21139030 | Interferon regulatory factor 3d |
Q29520634 | Interferon regulatory factor 4 |
Q21156369 | Interferon regulatory factor 4 |
Q21984131 | Interferon regulatory factor 4 |
Q29836049 | Interferon regulatory factor 4a |
Q21173373 | Interferon regulatory factor 5 |
Q21986023 | Interferon regulatory factor 5 |
Q29520808 | Interferon regulatory factor 6 |
Q5973476 | Interferon regulatory factor 6 |
Q14890131 | Interferon regulatory factor 6 |
Q29517588 | Interferon regulatory factor 7 |
Q21149685 | Interferon regulatory factor 7 |
Q21496522 | Interferon regulatory factor 7 |
Q29523653 | Interferon regulatory factor 8 |
Q29827969 | Interferon regulatory factor 8 |
Q21139165 | Interferon regulatory factor 8 |
Q21986019 | Interferon regulatory factor 8 |
Q21986029 | Interferon regulatory factor 9 |
Q23564086 | Peptidase B STY2782 |
Q21170943 | interferon regulatory factor 2 |
Q21173487 | interferon regulatory factor 9 |
Q78345506 | interferon-stimulated gene factor 3, gamma subunit | instance of | P31 |
Q38068405 | Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus | main subject | P921 |
Category:Interferon regulatory factors | wikimedia | |
Interferon regulatory factors | wikipedia | |
Facteur régulateur de l'interféron | wikipedia | |
Регуляторные факторы интерферона | wikipedia |
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