Prothrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non-vitamin K Anticoagulant Reversal

Prothrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non-vitamin K Anticoagulant Reversal is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/ALN.0000000000002399
P932PMC publication ID6234087
P698PubMed publication ID30157037

P50authorJames DouketisQ100404477
Jerrold LevyQ39056210
P2093author name stringTruman J Milling
Joshua N Goldstein
Thorsten Steiner
P2860cites workRapid large pulmonary embolism after prothrombin complex concentrate for warfarin reversal during colonoscopyQ88235369
Efficacy and safety of a 4-factor prothrombin complex concentrate for rapid vitamin K antagonist reversal in Japanese patients presenting with major bleeding or requiring urgent surgical or invasive procedures: a prospective, open-label, single-armQ88792311
European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral HemorrhageQ57384692
Bleeding risk assessment and management in atrial fibrillation patientsQ57627129
Periprocedural warfarin reversal with prothrombin complex concentrateQ57907745
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonistsQ59541570
Biochemical comparison of seven commercially available prothrombin complex concentratesQ81762781
Prevalence and implications of preinjury warfarin use: an analysis of the National Trauma DatabankQ83223998
Prothrombin complex concentrate (Octaplex): a Portuguese experience in 1152 patientsQ83748359
Intracardiac Thrombosis after Emergent Prothrombin Complex Concentrate Administration for Warfarin ReversalQ85648585
Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteersQ87842081
Prothrombin Complex Concentrate for Major Bleeding on Factor Xa Inhibitors: A Prospective Cohort StudyQ88128923
Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesQ24632951
The European guideline on management of major bleeding and coagulopathy following trauma: fourth editionQ27339343
Guidelines on oral anticoagulation with warfarin - fourth editionQ28240666
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjectsQ28247385
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke AssociationQ28262545
Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trialQ28265484
On the use of prothrombin complex concentrate in patients with coagulopathy requiring tooth extractionQ33392998
Case series of four-factor prothrombin complex concentrate for warfarin reversal before heart transplantationQ33422149
Four-factor prothrombin complex concentrate for life-threatening bleeds or emergent surgery: A retrospective evaluationQ33434776
Thrombogenicity of prothrombin complex concentratesQ33739978
Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registryQ34019616
Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesQ34252907
Emergency reversal of anticoagulation: from theory to real use of prothrombin complex concentrates. A retrospective Italian experienceQ34633407
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trialQ35219638
Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesQ35752584
Comparison between Prothrombin Complex Concentrate (PCC) and Fresh Frozen Plasma (FFP) for the Urgent Reversal of Warfarin in Patients with Mechanical Heart Valves in a Tertiary Care Cardiac CenterQ35897909
Death and disability from warfarin-associated intracranial and extracranial hemorrhagesQ36501858
Increased risk of volume overload with plasma compared with four-factor prothrombin complex concentrate for urgent vitamin K antagonist reversalQ36584522
Prothrombin complex concentrate for warfarin-induced bleeding in a patient with a mechanical aortic valve.Q37024233
Perioperative hemostatic management of patients treated with vitamin K antagonistsQ37306386
Real world usage of PCC to "rapidly" correct warfarin induced coagulopathyQ37306733
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitorQ37655400
Reversibility of Apixaban Anticoagulation with a Four-Factor Prothrombin Complex Concentrate in Healthy VolunteersQ37701146
Novel oral anticoagulants: implications in the perioperative settingQ37779223
Prothrombin complex concentrate for the urgent reversal of warfarin. Assessment of a standard dosing protocolQ38002605
Rapid Warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor VII, and prothrombin complex concentrate.Q38065635
Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrateQ38420791
Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study.Q38446560
Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trialQ38469560
Novel oral anticoagulants and reversal agents: Considerations for clinical developmentQ38509194
The Real-World Treatment of Hemorrhages Associated With Dabigatran and Rivaroxaban: A Multicenter EvaluationQ38535227
Prothrombin complex concentrate for rapid reversal of warfarin anticoagulation to allow neuraxial blockade.Q38561604
A new kid on the block: Outcomes with Kcentra 1 year after approvalQ38613007
Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery.Q48956680
Low-dose 3-factor prothrombin complex concentrate for warfarin reversal prior to heart transplantQ49062932
Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.Q49155525
Reversal agents for non-vitamin K antagonist oral anticoagulantsQ49970899
2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants: A Report of the American College of Cardiology Task Force on Expert Consensus Decision PathwaysQ50084592
A Retrospective Propensity Score-Matched Early Thromboembolic Event Analysis of Prothrombin Complex Concentrate vs Fresh Frozen Plasma for Warfarin Reversal Prior to Emergency Neurosurgical ProceduresQ50140400
Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal. A systematic review and meta-analysis.Q50225548
Questionable reversal of anticoagulation in the therapeutic management of cerebral haemorrhage associated with vitamin K antagonists.Q50773882
Use of Prothrombin Complex Concentrate for Warfarin Reversal Before the Performance of an Epidural Blood Patch in a Patient With Cortical Vein Thrombosis and Subdural Hematoma: A Case Report.Q51319610
An international, multicenter, prospective study of a prothrombin complex concentrate, Prothromplex Total®, in anticoagulant reversal.Q53077578
The benefit of prothrombin complex concentrate in decreasing neurological deterioration in patients with warfarin-associated intracerebral haemorrhage.Q53081949
Mortality in vitamin K antagonist-related intracerebral bleeding treated with plasma or 4-factor prothrombin complex concentrate.Q53090736
Prothrombin complex concentrate facilitates emergency spinal surgery in anticoagulated patients.Q53094595
Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized studyQ53167882
Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results.Q53254548
3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study.Q53343255
Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.Q38682353
Management of Periprocedural and Early Pericardial Effusions With Tamponade Following Ablation of Atrial Fibrillation With Uninterrupted Factor Xa Inhibitors: A Case SeriesQ38693172
When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH.Q38748850
Emergent reversal of vitamin K antagonists: addressing all the factorsQ38798692
Comparison of 3-Factor Prothrombin Complex Concentrate and Low-Dose Recombinant Factor VIIa for Warfarin ReversalQ38911940
Management of Patients on Non-Vitamin K Antagonist Oral Anticoagulants in the Acute Care and Periprocedural Setting: A Scientific Statement From the American Heart AssociationQ38975409
Reversal of rivaroxaban anticoagulation by nonactivated prothrombin complex concentrate in urgent surgeryQ38993962
Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016.Q39275339
Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trialQ39683385
Retrospective study of rFVIIa, 4-factor PCC, and a rFVIIa and 3-factor PCC combination in improving bleeding outcomes in the warfarin and non-warfarin patientQ39853866
Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulantsQ40081589
Thromboembolic outcomes after use of a four-factor prothrombin complex concentrate for vitamin K antagonist reversal in a real-world setting.Q40295049
Assessing the Efficacy of Prothrombin Complex Concentrate in Multiply Injured Patients With High-Energy Pelvic and Extremity Fractures.Q40462219
Evaluation of Warfarin Reversal with 4-Factor Prothrombin Complex Concentrate Compared to 3-Factor Prothrombin Complex Concentrate at a Tertiary Academic Medical Center.Q40470749
The effect of preinjury warfarin use on mortality rates in trauma patients: a European multicentre studyQ41471994
Comparative effectiveness of 3- versus 4-factor prothrombin complex concentrate for emergent warfarin reversalQ41522803
Emergency neurosurgical care in patients treated with apixaban: report of 2 casesQ41603394
Use of four-factor prothrombin complex concentrate for the mitigation of rivaroxaban-induced bleeding in an emergent coronary artery bypass graftQ42209654
Treatment of warfarin-related intracranial hemorrhage: a comparison of prothrombin complex concentrate and recombinant activated factor VII.Q42742774
Reversal of warfarin associated coagulopathy with 4-factor prothrombin complex concentrate in traumatic brain injury and intracranial hemorrhageQ43051467
Exploratory study on the reversal of warfarin with rFVIIa in healthy subjectsQ43102398
Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversalQ43269909
Hospitalization for vitamin-K-antagonist-related bleeding: treatment patterns and outcomeQ43650765
An exploratory cohort study comparing prothrombin complex concentrate and fresh frozen plasma for the treatment of coagulopathy after complex cardiac surgery.Q43802447
The effectiveness and safety of fixed low-dose prothrombin complex concentrates in patients requiring urgent reversal of warfarinQ44241618
Efficacy of the prothrombin complex concentrate prothromplex in patients requiring urgent reversal of vitamin K antagonists or presenting with uncontrolled bleeding: a retrospective, single center studyQ44313606
Thromboembolic safety and efficacy of prothrombin complex concentrates in the emergency reversal of warfarin coagulopathyQ44779656
The use of prothrombin complex concentrates in two patients with non-pulsatile left ventricular assist devicesQ44920280
The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt traumaQ45343282
Prothrombin complex concentrate accelerates international normalized ratio reversal and diminishes the extension of intracranial hemorrhage in geriatric trauma patientsQ45896567
Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials.Q46516369
Effects of prothrombin complex concentrate and recombinant activated factor VII on vitamin K antagonist induced anticoagulationQ46918805
Emergency reversal of anticoagulation: the real use of prothrombin complex concentrates: a prospective multicenter two year French study from 2006 to 2008.Q46959051
Effectiveness of Factor IX complex concentrate in reversing warfarin associated coagulopathy for intracerebral hemorrhageQ46979280
Intraoperative Administration of 4-Factor Prothrombin Complex Concentrate Reduces Blood Requirements in Cardiac TransplantationQ47202088
Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study.Q47914091
Use of low-dose prothrombin complex concentrate before lumbar punctureQ48132997
Reversal of anticoagulation with four-factor prothrombin complex concentrate without concurrent vitamin K (phytonadione) for urgent surgery in a patient at moderate-to-high risk for thromboembolism.Q48268883
The James Blundell Award Lecture 2006: transfusion and the treatment of haemorrhage: past, present and futureQ48327704
Rapid Anticoagulation Reversal With Prothrombin Complex Concentrate Before Emergency Brain Tumor SurgeryQ48614868
Prothrombin Complex Concentrates: An Alternative to Fresh Frozen PlasmaQ48651621
Treatment With Prothrombin Complex Concentrate to Enable Emergency Lumbar Puncture in Patients Receiving Vitamin K AntagonistsQ48826698
Is there a difference in efficacy, safety, and cost-effectiveness between 3-factor and 4-factor prothrombin complex concentrates among trauma patients on oral anticoagulants?Q48837088
Prothrombin complex concentrate versus fresh-frozen plasma for reversal of coagulopathy of trauma: is there a difference?Q48866953
Reversal of coagulopathy using prothrombin complex concentrates is associated with improved outcome compared to fresh frozen plasma in warfarin-associated intracranial hemorrhage.Q48876772
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectvitaminQ34956
vitamin KQ182338
(E)-phytonadioneQ186093
anticoagulantQ215118
anticoagulationQ63279445
P1104number of pages14
P304page(s)1171-1184
P577publication date2018-12-01
P1433published inAnesthesiologyQ2012635
P1476titleProthrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non-vitamin K Anticoagulant Reversal
P478volume129

Reverse relations

cites work (P2860)
Q90368700Catastrophic Intracardiac Thrombosis During Emergency Repair of an Expanding Aortic Pseudoaneurysm: A Case Report
Q89458478Management of two major postoperative bleeding complications after mandible reconstruction with fibula free flap in a patient under chronic warfarin treatment
Q99203763Recent advances in use of fresh frozen plasma, cryoprecipitate, immunoglobulins, and clotting factors for transfusion support in patients with hematologic disease

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