SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy

scientific article published on 01 January 2018

SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2018.01519
P932PMC publication ID6331469
P698PubMed publication ID30670969

P50authorPei-Qing LiuQ89508083
P2093author name stringXiaoying Zhang
Zhen Guo
Zhenzhen Li
Jingyan Li
Zhuoming Li
Panxia Wang
Yao Zhong
P2860cites workPhosphorylation of NFATc4 by p38 mitogen-activated protein kinasesQ24537383
NFAT: ubiquitous regulator of cell differentiation and adaptationQ24673318
Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-ATQ28139459
Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localizationQ28143654
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathwayQ28255002
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repressionQ28273795
Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activityQ28568033
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophyQ28579323
Regulation of cardiac hypertrophy by intracellular signalling pathwaysQ29615166
Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophyQ30825127
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.Q33817548
Functional role of Calstabin2 in age-related cardiac alterations.Q34675791
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-JunQ35458082
SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300.Q51365104
NFATc4 and myocardin synergistically up-regulate the expression of LTCC α1C in ET-1-induced cardiomyocyte hypertrophy.Q51463097
SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy.Q52669826
[Huangqi Danshen decoction attenuates isoproterenol-induced myocardial remodeling via STIM1, TRPC1, CaN and NFATc3 pathways in rats].Q52817006
Stress-Activated Protein Kinases in Spinal Cord Injury: Focus on Roles of p38.Q54121159
Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.Q54521190
Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats.Q54573202
Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.Q55426178
A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATpQ73731442
The role and mechanisms of action of SIRT6 in the suppression of postoperative epidural scar formationQ87479838
JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing β-MHC expressionQ88647807
Hypertrophy of the heart: a new therapeutic target?Q35739349
Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes.Q36422429
Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and DiabetesQ36795482
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28bQ36968417
Molecular targets and regulators of cardiac hypertrophy.Q37647071
The alpha1-adrenergic receptors in cardiac hypertrophy: signaling mechanisms and functional implicationsQ38546358
MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytesQ38785040
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases.Q39003859
SIRT6: Novel Mechanisms and Links to Aging and DiseaseQ39005741
Calcineurin signaling in the heart: The importance of time and place.Q39050949
STAT3 Suppression Is Involved in the Protective Effect of SIRT6 Against Cardiomyocyte HypertrophyQ40695454
Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cellsQ41075480
Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathwayQ41135875
Local microRNA-133a downregulation is associated with hypertrophy in the dyssynchronous heartQ41239272
Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signallingQ41520454
Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1.Q46713241
Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6.Q47301606
Nuclear sirtuins and inflammatory signaling pathwaysQ47353459
Perturbations of NAD salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscleQ47689677
The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.Q47858886
Expression of nuclear factor of activated T cells (NFAT) and downstream muscle-specific proteins in ground squirrel skeletal and heart muscle during hibernationQ48099947
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in miceQ50098440
SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart.Q50107292
Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular DiseaseQ50290643
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)1519
P577publication date2018-01-01
P1433published inFrontiers in PharmacologyQ2681208
P1476titleSIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy
P478volume9

Search more.