A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

scientific article published on 01 December 2019

A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/14756366.2018.1488697
P932PMC publication ID6327984
P698PubMed publication ID30734599

P50authorHong-Xin NiuQ88728426
P2093author name stringYihua Chen
Yue Shi
Hongying Li
Siqi Chen
Xiaoyu Wu
Dongdong Tang
Xiaoqiao Wang
Yaowei Zou
P2860cites workValsartan ameliorates podocyte loss in diabetic mice through the Notch pathway.Q53145678
Advanced oxidation protein products as a novel marker of oxidative stress in uremiaQ71324551
Markers of oxidative protein damage in plasma and urine of type 2 diabetic patientsQ82617038
Comment on Sharma. Mitochondrial Hormesis and Diabetic Complications. Diabetes 2015;64:663-672Q85942162
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trialQ95817860
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trialsQ24632223
A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational ModificationsQ26769678
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosisQ29616513
Mitochondria, oxidative stress and cell deathQ29618996
Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitroQ33701530
Podocytes, signaling pathways, and vascular factors in diabetic kidney diseaseQ33821237
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.Q34277437
A mitochondrial superoxide theory for oxidative stress diseases and agingQ35014145
Mycophenolate mofetil and valsartan inhibit podocyte apoptosis in streptozotocin-induced diabetic ratsQ35026016
Optimisation of an Advanced Oxidation Protein Products Assay: Its Application to Studies of Oxidative Stress in Diabetes MellitusQ35737933
Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathyQ36319830
Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK-NF-κB Signaling Cascade: Protective Effects of ApocyninQ36532079
Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injuryQ36999928
Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysisQ37166321
Mechanisms of renal apoptosis in health and diseaseQ37218601
Diabetes and Kidney Disease: Role of Oxidative StressQ37349206
Podocyte loss and progressive glomerular injury in type II diabetesQ37362675
Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic NephropathyQ37521278
2',7'-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversyQ37724866
Oxidative stress, anti-oxidant therapies and chronic kidney disease.Q37979867
Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte ApoptosisQ38729813
Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions.Q38737184
Role of mitochondrial dysfunction in renal fibrosis promoted by hypochlorite-modified albumin in a remnant kidney model and protective effects of antioxidant peptide SS-31.Q38891120
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms.Q38911994
Smad3/Nox4-mediated mitochondrial dysfunction plays a crucial role in puromycin aminonucleoside-induced podocyte damageQ38955832
Mitochondria-targeted antioxidant peptide SS31 prevents hypoxia/reoxygenation-induced apoptosis by down-regulating p66Shc in renal tubular epithelial cellsQ39097729
Regulation of podoplanin expression by microRNA-29b associates with its antiapoptotic effect in angiotensin II-induced injury of human podocytes.Q40004766
Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanismsQ43281714
Advanced oxidation protein products activate vascular endothelial cells via a RAGE-mediated signaling pathway.Q44528051
Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injuryQ44922430
Total antioxidant status and markers of oxidative stress in subjects with normal or impaired glucose regulation (IFG, IGT) in diabetic patientsQ46060210
Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathyQ46616439
Advanced oxidation protein products promote inflammation in diabetic kidney through activation of renal nicotinamide adenine dinucleotide phosphate oxidaseQ46823976
Mitochondria-Targeted Antioxidant Peptide SS31 Protects Cultured Human Lens Epithelial Cells against Oxidative StressQ46826277
Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathyQ46870214
Advanced oxidative and glycoxidative protein damage markers in the elderly with type 2 diabetes.Q46881644
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectmitochondrionQ39572
drug discoveryQ1418791
P304page(s)394-404
P577publication date2019-12-01
P1433published inJournal of Enzyme Inhibition and Medicinal ChemistryQ15708877
P1476titleA mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro
P478volume34

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cites work (P2860)
Q99619235Flavonoid compound breviscapine suppresses human osteosarcoma Saos-2 progression property and induces apoptosis by regulating mitochondria-dependent pathway
Q91690552Mitochondria-Targeted Peptide SS31 Attenuates Renal Tubulointerstitial Injury via Inhibiting Mitochondrial Fission in Diabetic Mice
Q97646299Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
Q89896008The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

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