Role of spironolactone in the treatment of heart failure with preserved ejection fraction

Role of spironolactone in the treatment of heart failure with preserved ejection fraction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.21037/ATM.2018.11.16
P932PMC publication ID6312809
P698PubMed publication ID30603649

P2093author name stringConstantine E Kosmas
Andreas Sourlas
Delia Silverio
Eliscer Guzman
Peter D Montan
P2860cites workHeart Failure with Preserved Ejection Fraction - Concept, Pathophysiology, Diagnosis and Challenges for TreatmentQ26747554
Effect of Mineralocorticoid Receptor Antagonists on Cardiac Structure and Function in Patients With Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: A Meta-Analysis and Systematic ReviewQ26783958
Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapiesQ27000263
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study InvestigatorsQ28372091
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart AssociationQ30238784
Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive ratsQ32055195
Spironolactone for heart failure with preserved ejection fractionQ34414462
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatmentQ34664894
Effects of mineralocorticoid receptor antagonists in patients with preserved ejection fraction: a meta-analysis of randomized clinical trialsQ35018046
Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemicQ35040738
Mineralocorticoid receptor antagonists for heart failure: systematic review and meta-analysisQ36208986
Aldosterone and the risk of hypertensionQ36747846
The incidence and implications of aldosterone breakthroughQ36918649
Left ventricular hypertrophy patterns and incidence of heart failure with preserved versus reduced ejection fractionQ37434977
The progression of hypertensive heart diseaseQ37832070
Vascular actions of aldosteroneQ38061580
Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trialQ38455453
Mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction (HFpEF).Q38592650
Role of mineralocorticoid receptor activation in cardiac diastolic dysfunctionQ39042819
Addition of spironolactone to angiotensin-converting enzyme inhibition in heart failure improves endothelial vasomotor dysfunction: role of vascular superoxide anion formation and endothelial nitric oxide synthase expressionQ43852493
Eplerenone in Patients with Systolic Heart Failure and Mild SymptomsQ44272913
Immediate administration of mineralocorticoid receptor antagonist spironolactone prevents post-infarct left ventricular remodeling associated with suppression of a marker of myocardial collagen synthesis in patients with first anterior acute myocardQ44430971
Additive amelioration of left ventricular remodeling and molecular alterations by combined aldosterone and angiotensin receptor blockade after myocardial infarctionQ46539706
Interaction Between Spironolactone and Natriuretic Peptides in Patients With Heart Failure and Preserved Ejection Fraction: From the TOPCAT TrialQ48238085
Biological Phenotypes of Heart Failure With Preserved Ejection Fraction.Q50098362
Serum aldosterone and its relationship to left ventricular structure and geometry in patients with preserved left ventricular ejection fraction.Q51423999
Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trialQ52803941
Effect of Aldosterone Antagonism on Exercise Tolerance in Heart Failure With Preserved Ejection Fraction.Q53563361
Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart FailureQ57259661
Aldosterone Receptor Blockade in Heart Failure with Preserved Ejection FractionQ91855803
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectheart failureQ181754
ejection fractionQ641303
Heart failure with preserved ejection fractionQ3799239
P304page(s)461
P577publication date2018-12-01
P1433published inAnnals of Translational MedicineQ26842362
P1476titleRole of spironolactone in the treatment of heart failure with preserved ejection fraction
P478volume6