Sclerostin Modulation Holds Promise for Dental Indications

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Sclerostin Modulation Holds Promise for Dental Indications is …
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P356DOI10.3390/HEALTHCARE6040134
P932PMC publication ID6316148
P698PubMed publication ID30477095

P2093author name stringJuan Martin Palomo
Abbas R Zaher
Leena Palomo
Mohamed G Hassan
P2860cites workOsteocyte control of bone formation via sclerostin, a novel BMP antagonistQ24300347
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Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitroQ43271941
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Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signalingQ47871615
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The amazing osteocyteQ24635849
Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formationQ28267745
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formationQ28269067
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strengthQ28274891
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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosisQ28302443
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Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal womenQ33786865
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SclerostinQ34211729
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Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 casesQ35762495
Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse modelQ35774786
Cytokine expression and accelerated tooth movementQ35866637
SOST/sclerostin, an osteocyte-derived negative regulator of bone formationQ36115718
The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT).Q36190027
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Oral fluid-based biomarkers of alveolar bone loss in periodontitis.Q36792245
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RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis.Q36973041
Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.Q37091516
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RANK/RANKL/OPG during orthodontic tooth movementQ37472206
Osteocyte-driven bone remodelingQ37626024
Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats.Q50574453
Saturation of the biological response to orthodontic forces and its effect on the rate of tooth movement.Q50592066
Sclerostin antibody stimulates bone regeneration after experimental periodontitis.Q50956663
Oral post-surgical complications following the administration of bisphosphonates given for osteopenia related to malignancy.Q51812224
Changes in the spatial distribution of sclerostin in the osteocytic lacuno-canalicular system in alveolar bone due to orthodontic forces, as detected on multimodal confocal fluorescence imaging analyses.Q53016716
Receptor activator of nuclear factor-κB ligand and sclerostin expression in osteocytes of alveolar bone in rats with ligature-induced periodontitis.Q53031123
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Sclerostin in Mineralized Matrices and van Buchem DiseaseQ57848944
Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membraneQ59100551
Gingival fluid IL-1 beta and IL-6 levels in menopauseQ72288376
Chemokines are upregulated during orthodontic tooth movementQ73040018
TGF-beta 1 and IFN-gamma direct macrophage activation by TNF-alpha to osteoclastic or cytocidal phenotypeQ73112905
Biological reaction of alveolar bone to orthodontic tooth movementQ77398070
Mechanical stimulation in vivo reduces osteocyte expression of sclerostinQ79448199
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bonesQ84033150
Induction of cytokines, MMP9, TIMPs, RANKL and OPG during orthodontic tooth movementQ84985728
Kinetics of interleukin-6 and chemokine ligands 2 and 3 expression of periodontal tissues during orthodontic tooth movementQ85015506
The role of osteocytes in bone resorption during orthodontic tooth movementQ85991589
Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin, and Receptor Activator of Nuclear Factor-κB Ligand in PeriodontitisQ86137339
Bone matrix quality after sclerostin antibody treatmentQ87177089
Experimental model of tooth movement in mice: a standardized protocol for studying bone remodeling under compression and tensile strainsQ87409994
Serum sclerostin and adverse outcomes in nondialyzed chronic kidney disease patientsQ87436498
Periodontal cytokines profile under orthodontic force and extracorporeal shock wave stimuli in a rat modelQ87466465
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)134
P577publication date2018-11-23
P1433published inHealthcareQ27726790
P1476titleSclerostin Modulation Holds Promise for Dental Indications
P478volume6

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