Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

scholarly article by Uddin Md Nazim et al published 12 December 2018 in Molecular Medicine Reports

Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3892/MMR.2018.9757
P932PMC publication ID6323218
P698PubMed publication ID30569150

P2093author name stringSang-Youel Park
Uddin Md Nazim
Honghua Yin
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The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cellsQ43713494
Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.Q43903493
Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene CelastrolQ44603146
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Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.Q46644015
Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.Q53285162
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PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy fluxQ33688828
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Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathwaysQ39501449
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Inhibition of autophagy promotes apoptosis and enhances anticancer efficacy of adriamycin via augmented ROS generation in prostate cancer cellsQ41914959
Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cellsQ41935560
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
reactive oxygen speciesQ424361
molecular medicineQ3523816
P577publication date2018-12-12
P1433published inMolecular Medicine ReportsQ26842180
P1476titleAutophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Reverse relations

cites work (P2860)
Q91660559Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
Q64253207Natural Product Mediated Regulation of Death Receptors and Intracellular Machinery: Fresh from the Pipeline about TRAIL-Mediated Signaling and Natural TRAIL Sensitizers

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