Abstract is: Ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. This compound occurs in relatively few organisms, notably Actinomycetota, "Cyanobacteria", and certain fungi. Ergothioneine was discovered in 1909 and named after the ergot fungus from which it was first purified, with its structure being determined in 1911. In humans, ergothioneine is acquired exclusively through the diet and accumulates in erythrocytes, bone marrow, liver, kidney, seminal fluid, and eyes. Although the effect of ergothioneine in vivo is under preliminary research, its physiological role in humans is unknown. Ergothioneine is sold as a dietary supplement.
P703 | found in taxon | Caenorhabditis elegans | Q91703 |
P2067 | mass | 229.088498 | |
P361 | part of | ergothioneine metabolic process | Q22274961 |
ergothioneine biosynthetic process | Q22274965 | ||
ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine | Q22274967 | ||
ergothioneine catabolic process | Q22274972 | ||
P3364 | stereoisomer of | L-(+)-Ergothioneine | Q72471043 |
P2868 | subject has role | antioxidant | Q133948 |
Q50299548 | SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol |
Q22274967 | ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine |
Q22274965 | ergothioneine biosynthetic process |
Q22274972 | ergothioneine catabolic process |
Q22274961 | ergothioneine metabolic process |
Q42965670 | A COLORIMETRIC MICRO-METHOD FOR THE DETERMINATION OF GLUTATHIONE |
Q45036126 | A Safety Evaluation of a Nature-Identical l-Ergothioneine in Sprague Dawley Rats |
Q53357013 | A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation. |
Q41600221 | Amniotic fluid l-ergothioneine concentrations in pregnant sheep after natural mating and transfer of vitrified/thawed in-vitro produced embryos |
Q76486368 | An ergothioneine-dependent oxidation of reduced pyridine neucleotides by methemoglobin and metmyglobin. Stimulation by thyroxine |
Q34848103 | Antioxidative activity and antidiscoloration efficacy of ergothioneine in mushroom (Flammulina velutipes) extract added to beef and fish meats |
Q64116113 | Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta) |
Q50945965 | Aqueous solutions of some basic dyes--their use in the cytochemical detection of DNA |
Q40248296 | BIOSYNTHESIS OF ERGOTHIONEINE AND HERCYNINE BY MYCOBACTERIA |
Q76833297 | COMPOSITION AND CHEMICOPHYSICAL CHARACTERISTICS OF EQUINE SPERM |
Q28538290 | Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults |
Q40048041 | Complexing of copper ion by ergothioneine |
Q33957481 | Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites [...] |
Q37433153 | DEGRADATION OF ERGOTHIONEINE BY CELL-FREE EXTRACTS OF ALCALIGENES FAECALIS. II. PRODUCTION OF GLUTAMIC ACID |
Q76992721 | DETERMINATION OF ERYTHROCYTE GLUTATHIONE BY AN AROMATIC NITRO DISULFIDE: 5,5'-DITHIOBIS-(2-NITROBENZOIC) ACID |
Q34646899 | Dietary sources and antioxidant effects of ergothioneine |
Q115784055 | Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model |
Q38802915 | Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis |
Q59273889 | Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? |
Q39833061 | Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. |
Q38698212 | Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis. |
Q36830164 | Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice. |
Q34594964 | Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). |
Q52311187 | Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa. |
Q40796107 | Homologous copper(1)-(thiolate)2-chromophores in yeast copper thionein |
Q28501829 | In vitro reconstitution of Mycobacterial ergothioneine biosynthesis |
Q67233487 | Interaction of ergothioneine with metal ions and metalloenzymes |
Q45296520 | L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts |
Q44805379 | L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids. |
Q48565007 | L-ergothioneine supplementation during culture improves quality of bovine in vitro-produced embryos |
Q40244113 | Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence? |
Q35824616 | Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate |
Q59335062 | Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism |
Q43297582 | Mushroom intolerance: a novel diet-gene interaction in Crohn's disease |
Q40257774 | Oxidation-reduction reactions of copper-thiolate centres in Cu-thionein |
Q40162381 | Oxidative-stress detoxification and signalling in cyanobacteria: the crucial glutathione synthesis pathway supports the production of ergothioneine and ophthalmate. |
Q113954134 | Phosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma |
Q34906980 | Plasma L-ergothioneine measurement by high-performance liquid chromatography and capillary electrophoresis after a pre-column derivatization with 5-iodoacetamidofluorescein (5-IAF) and fluorescence detection |
Q41896390 | Production of ergothioneine by Methylobacterium species. |
Q86392272 | Quantification of L-ergothioneine in human plasma and erythrocytes by liquid chromatography-tandem mass spectrometry |
Q58294574 | Quantification of L-ergothioneine in whole blood by hydrophilic interaction ultra-performance liquid chromatography and UV-detection |
Q60096157 | Radiation Protective Effect and Pharmacologically Changed Activity of the Reticulo-endothelial System |
Q93162012 | Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster |
Q36281665 | Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity |
Q86863210 | Reproductive safety evaluation of L-Ergothioneine |
Q64270070 | Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn's Disease |
Q76459877 | Some new compounds in the lens |
Q27701026 | Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC |
Q41626709 | The role of dietary ergothioneine in the development of diabetes mellitus |
Q34613774 | The unusual amino acid L-ergothioneine is a physiologic cytoprotectant |
Q43322149 | Ultra-performance liquid chromatographic determination of L-ergothioneine in commercially available classes of cow milk |
Q50466319 | Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites. |
Q51487878 | Validation of a HILIC Method for the Analysis of Ergothioneine in Fermentation Broth. |
Q36817792 | Wide tolerance to amino acids substitutions in the OCTN1 ergothioneine transporter |
Q72471043 | L-(+)-Ergothioneine | stereoisomer of | P3364 |
Category:Ergothioneine | wikimedia | |
azb | ارقوتیونین | wikipedia |
Ergothioneine | wikipedia | |
Ergotioneina | wikipedia | |
Basque language (eu / Q8752) | Ergotioneina | wikipedia |
Persian (fa / Q9168) | ارگوتیونین | wikipedia |
Ergothionéine | wikipedia | |
Ergotioneina | wikipedia | |
エルゴチオネイン | wikipedia | |
Ergothioneïne | wikipedia | |
Ergotioneina | wikipedia | |
Serbo-Croatian (sh / Q9301) | Ergotionein | wikipedia |
Ergotionein | wikipedia | |
Ergothioneine | wikipedia |
Search more.