scholarly article | Q13442814 |
P50 | author | Daisuke Sakai | Q58665559 |
Lachlan J Smith | Q89853917 | ||
Lara Silverman | Q92515528 | ||
Christine L Le Maitre | Q39409436 | ||
Conor T. Buckley | Q42780153 | ||
P2093 | author name string | Jeffrey C Lotz | |
Robert L Mauck | |||
Neil R Malhotra | |||
P2860 | cites work | Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc | Q22000853 |
The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration | Q24817050 | ||
Molecular mechanisms of biological aging in intervertebral discs | Q26764941 | ||
Adjacent Segment Pathology after Lumbar Spinal Fusion | Q26782171 | ||
Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration | Q26783031 | ||
Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration | Q26783279 | ||
Biological Treatment Approaches for Degenerative Disc Disease: A Review of Clinical Trials and Future Directions | Q28080259 | ||
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 | Q28083357 | ||
Gene therapy approaches to regenerating the musculoskeletal system | Q28083399 | ||
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. | Q28131663 | ||
Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc | Q28567959 | ||
MSC response to pH levels found in degenerating intervertebral discs | Q28583879 | ||
The shear modulus of the nucleus pulposus measured using magnetic resonance elastography: a potential biomarker for intervertebral disc degeneration | Q30407959 | ||
Nucleus pulposus tissue engineering: a brief review | Q30434295 | ||
Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs | Q30436607 | ||
Correlations between quantitative T2 and T1ρ MRI, mechanical properties and biochemical composition in a rabbit lumbar intervertebral disc degeneration model. | Q31083149 | ||
Evaluation of quantitative magnetic resonance imaging, biochemical and mechanical properties of trypsin-treated intervertebral discs under physiological compression loading | Q31144007 | ||
Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro | Q33568772 | ||
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix | Q33617497 | ||
Development and validation of a bioreactor system for dynamic loading and mechanical characterization of whole human intervertebral discs in organ culture | Q33717494 | ||
Novel diagnostic and prognostic methods for disc degeneration and low back pain | Q33806592 | ||
In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus. | Q33861797 | ||
Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study | Q33972441 | ||
Differential prescribing of opioid analgesics according to physician specialty for Medicaid patients with chronic noncancer pain diagnoses | Q34154381 | ||
The physiology of low back pain | Q34298257 | ||
New treatments and imaging strategies in degenerative disease of the intervertebral disks. | Q34313700 | ||
A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics | Q34360743 | ||
Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. | Q34613936 | ||
Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications | Q34625727 | ||
Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs. | Q34765418 | ||
Region specific response of intervertebral disc cells to complex dynamic loading: an organ culture study using a dynamic torsion-compression bioreactor. | Q34981006 | ||
Complex loading affects intervertebral disc mechanics and biology | Q35112662 | ||
Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months | Q35238021 | ||
IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro | Q43241239 | ||
Intradiscal measurements of pH in patients with lumbar rhizopathies | Q44186933 | ||
Biological response of the intervertebral disc to repetitive short-term cyclic torsion | Q45007296 | ||
Long-term outcomes of lumbar fusion among workers' compensation subjects: a historical cohort study | Q46931048 | ||
A large animal model that recapitulates the spectrum of human intervertebral disc degeneration. | Q47130586 | ||
Inflammatory biomarkers of low back pain and disc degeneration: a review | Q47229498 | ||
Optimization of Hydrostatic Pressure Loading on Nucleus Pulposus Cells using a High-throughput Bioreactor | Q47244504 | ||
Animal models for studying the etiology and treatment of low back pain. | Q47766560 | ||
Priming and cryopreservation of microencapsulated marrow stromal cells as a strategy for intervertebral disc regeneration | Q48143583 | ||
Do modic changes, disc degeneration, translation and angular motion affect facet osteoarthritis of the lumbar spine | Q49569647 | ||
Non-viral gene delivery systems for tissue repair and regeneration | Q49962874 | ||
Influence of lifestyle characteristics and VDR polymorphisms as risk factors for intervertebral disc degeneration: a case-control study. | Q50328604 | ||
In vitro extracellular matrix accumulation of nasal and articular chondrocytes for intervertebral disc repair. | Q50871144 | ||
'Stress' distributions inside intervertebral discs. The effects of age and degeneration. | Q50987212 | ||
"Managing" the Placebo Effect: The Single-Blind Placebo Lead-in Response in Two Pain Models. | Q50988088 | ||
Intervertebral disc cell-mediated mesenchymal stem cell differentiation. | Q51339330 | ||
Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor. | Q51577527 | ||
Low back pain: a call for action. | Q51759899 | ||
What low back pain is and why we need to pay attention. | Q51759902 | ||
National Trends for Primary and Revision Lumbar Disc Arthroplasty Throughout the United States. | Q52584292 | ||
The transpedicular approach as an alternative route for intervertebral disc regeneration. | Q52633401 | ||
Prevention and treatment of low back pain: evidence, challenges, and promising directions. | Q52638471 | ||
Biological performance of cell-encapsulated methacrylated gellan gum-based hydrogels for nucleus pulposus regeneration. | Q53042239 | ||
Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments. | Q53252239 | ||
Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety. | Q53570737 | ||
Matrix-assisted cell transfer for intervertebral disc cell therapy. | Q53676817 | ||
Cell therapy for intervertebral disc repair: Clinical perspective. | Q54941293 | ||
Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside. | Q55035190 | ||
Contribution of disc degeneration to osteophyte formation in the cervical spine: a biomechanical investigation | Q74525865 | ||
Comparison of animals used in disc research to human lumbar disc geometry | Q79702074 | ||
Adequacy of herniated disc tissue as a cell source for nucleus pulposus regeneration | Q83150045 | ||
Immunoselected STRO-3+ mesenchymal precursor cells and restoration of the extracellular matrix of degenerate intervertebral discs | Q83613400 | ||
Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies | Q84115660 | ||
Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation | Q84357266 | ||
Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus | Q88101237 | ||
Low back pain: a major global challenge | Q88158430 | ||
Quantitative MRI correlates with histological grade in a percutaneous needle injury mouse model of disc degeneration | Q88451787 | ||
Donor Variation and Optimization of Human Mesenchymal Stem Cell Chondrogenesis in Hyaluronic Acid | Q88787534 | ||
Chondrocyte and mesenchymal stem cell derived engineered cartilage exhibits differential sensitivity to pro-inflammatory cytokines | Q88890180 | ||
Intervertebral disc development and disease-related genetic polymorphisms | Q91792231 | ||
Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture | Q35534857 | ||
Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells. | Q35557848 | ||
Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρ dispersion and -OH chemical exchange saturation transfer (RROC). | Q35880100 | ||
Adjacent Segment Degeneration Versus Disease After Lumbar Spine Fusion for Degenerative Pathology: A Systematic Review With Meta-Analysis of the Literature | Q35912087 | ||
Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix | Q35963853 | ||
Nutrition of the intervertebral disc | Q35963858 | ||
Modic type I change may predict rapid progressive, deforming disc degeneration: a prospective 1-year follow-up study | Q36004356 | ||
Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells | Q36084826 | ||
Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. | Q36392389 | ||
Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. | Q36477385 | ||
Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies | Q36662214 | ||
Comparison of artificial total disc replacement versus fusion for lumbar degenerative disc disease: a meta-analysis of randomized controlled trials | Q36937794 | ||
Cell transplantation in lumbar spine disc degeneration disease | Q36985332 | ||
Intervertebral disc: anatomy-physiology-pathophysiology-treatment | Q37062477 | ||
Analysis of quantitative magnetic resonance imaging and biomechanical parameters on human discs with different grades of degeneration | Q37075958 | ||
The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain. | Q37293616 | ||
The transpedicular approach for the study of intervertebral disc regeneration strategies: in vivo characterization | Q37313800 | ||
Biological repair of the degenerated intervertebral disc by the injection of growth factors | Q37324308 | ||
Future perspectives of cell-based therapy for intervertebral disc disease | Q37324319 | ||
Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation. | Q37493543 | ||
Adipose, Bone Marrow and Synovial Joint-Derived Mesenchymal Stem Cells for Cartilage Repair | Q37516178 | ||
Economic impact of improving outcomes of lumbar discectomy | Q37612581 | ||
2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering | Q37772139 | ||
Degeneration and regeneration of the intervertebral disc: lessons from development | Q37814771 | ||
Assessing the safety of stem cell therapeutics | Q37882177 | ||
Hydrogels in acellular and cellular strategies for intervertebral disc regeneration. | Q37954579 | ||
Prospective study of disc repair with allogeneic chondrocytes presented at the 2012 Joint Spine Section Meeting | Q38058815 | ||
Diagnostic criteria and treatment of discogenic pain: a systematic review of recent clinical literature | Q38132996 | ||
Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 7: lumbar fusion for intractable low-back pain without stenosis or spondylolisthesis | Q38224857 | ||
Safety of gene therapy: new insights to a puzzling case | Q38253185 | ||
Delivery systems for the treatment of degenerated intervertebral discs | Q38275812 | ||
The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies | Q38347635 | ||
Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials | Q38527836 | ||
Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. | Q38653250 | ||
Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs). | Q38668901 | ||
Hypoxic Expansion of Human Mesenchymal Stem Cells Enhances Three-Dimensional Maturation of Tissue-Engineered Intervertebral Discs | Q38728255 | ||
Cell-based therapies for intervertebral disc and cartilage regeneration- Current concepts, parallels, and perspectives | Q38814837 | ||
ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with Modic changes | Q38990683 | ||
Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential | Q39030766 | ||
Cell therapy for the degenerating intervertebral disc | Q39041854 | ||
US Spending on Personal Health Care and Public Health, 1996-2013. | Q39062182 | ||
An injectable hydrogel incorporating mesenchymal precursor cells and pentosan polysulphate for intervertebral disc regeneration | Q39094088 | ||
Thermally triggered hydrogel injection into bovine intervertebral disc tissue explants induces differentiation of mesenchymal stem cells and restores mechanical function | Q39158557 | ||
Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells: A Randomized Controlled Trial. | Q39166995 | ||
Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro | Q39223995 | ||
Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc: reduced risk of osteophyte formation | Q39280312 | ||
MR Elastography-derived Stiffness: A Biomarker for Intervertebral Disc Degeneration | Q39283455 | ||
Swelling pressure of the lumbar intervertebral discs: influence of age, spinal level, composition, and degeneration | Q39298783 | ||
Nutrition of the intervertebral disc: solute transport and metabolism | Q39345516 | ||
Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc | Q39346240 | ||
Influence of Complex Loading Conditions on Intervertebral Disc Failure. | Q39760590 | ||
Bone Marrow Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity and Oxygen Concentration: Implications for Cell-based Regenerative Therapy. | Q40249210 | ||
Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study | Q40380010 | ||
Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort. | Q40442930 | ||
Biological challenges for regeneration of the degenerated disc using cellular therapies. | Q40451370 | ||
Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus | Q41154197 | ||
Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently. | Q41214400 | ||
Injectable microcryogels reinforced alginate encapsulation of mesenchymal stromal cells for leak-proof delivery and alleviation of canine disc degeneration | Q41246972 | ||
A prospective randomized multicenter phase I/II clinical trial to evaluate safety and efficacy of NOVOCART disk plus autologous disk chondrocyte transplantation in the treatment of nucleotomized and degenerative lumbar disks to avoid secondary disea | Q41484364 | ||
Axial T1ρ MRI as a diagnostic imaging modality to quantify proteoglycan concentration in degenerative disc disease. | Q41720554 | ||
Surgical versus non-surgical treatment of chronic low back pain: a meta-analysis of randomised trials | Q41903419 | ||
Alginate Microencapsulation Technology for the Percutaneous Delivery of Adipose-Derived Stem Cells | Q42477009 | ||
Innervation of anulus tears: an experimental animal study | Q43072854 | ||
Nerves are more abundant than blood vessels in the degenerate human intervertebral disc. | Q43101289 | ||
P433 | issue | 4 | |
P304 | page(s) | e1036 | |
P577 | publication date | 2018-10-08 | |
P1433 | published in | JOR Spine | Q73541371 |
P1476 | title | Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section | |
P478 | volume | 1 |
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