Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis

scientific article published on 02 January 2012

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TRSL.2011.12.003
P698PubMed publication ID22633099

P50authorIgnazio BarbagalloQ47757242
Fabio GalvanoQ30512663
Francesco CappelloQ37843560
P2093author name stringGiovanni Li Volti
Federico Salamone
Andrea Mangiameli
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Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injuryQ46726944
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitisQ46802365
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Iron-induced oxidant stress leads to irreversible mitochondrial dysfunctions and fibrosis in the liver of chronic iron-dosed gerbils. The effect of silybin.Q54314248
Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis PatientsQ57760193
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Nuclear factor-kappaB inhibition and non-alcoholic steatohepatitis: inflammation as a target for therapy.Q61763019
Antioxidant activity of silybin in vivo during long-term iron overload in ratsQ71584393
Scavenging of reactive oxygen species by silibinin dihemisuccinateQ72174184
A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver diseaseQ95000126
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitisQ24625697
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Purification and properties of acyl-CoA oxidase from rat liverQ28282715
Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severityQ28297290
Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart StudyQ34501554
Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic miceQ35153847
iNOS-mediated nitric oxide production and its regulationQ35789162
Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient dietQ36558384
The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injuryQ36571400
Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseasesQ36572087
Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axisQ36895504
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjectsQ37068823
Peroxynitrite detoxification and its biologic implications.Q37171996
Redox regulation of nuclear post-translational modifications during NF-kappaB activationQ37388619
Histopathology of non-alcoholic fatty liver diseaseQ37612118
Fatty liver and lipotoxicityQ37621647
The role of oxidative stress in non-alcoholic steatohepatitisQ37868177
Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob miceQ38310192
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontinQ38338847
Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophagesQ40724940
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturaseQ42563412
A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observationsQ42844656
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.Q42981378
A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.Q43223041
Silibinin protects mice from T cell-dependent liver injuryQ44555689
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patientsQ44615824
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in miceQ45175704
Liver NF-kappaB and AP-1 DNA binding in obese patientsQ46150605
Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.Q46254429
P433issue6
P304page(s)477-486
P577publication date2012-01-02
P1433published inTranslational ResearchQ15761127
P1476titleSilibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
P478volume159

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cites work (P2860)
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